Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression

Tillmann, Sandra; Wegener, Gregers

doi:10.1016/j.bbr.2018.08.025

Cited by 29 publications

(27 citation statements)

References 59 publications

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“…Moreover, researchers are exploring how the gastrointestinal system can affect anxiety. Recent studies reveal administering certain probiotics can decrease EPM open arm time in rats, while probiotic treatment in humans can decrease neurophysiological and panic anxiety (Tillmann and Wegener, 2019 ; Tran et al, 2019 ). Patients suffering from anxiety commonly report uncomfortable interoceptive sensations in their stomach, like tightening or “dropping,” and the gut-brain emotional connection is still not fully understood (Shapiro and Nguyen, 2010 ).…”

Section: Other Perspectivesmentioning

confidence: 99%

To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays

La-Vu

Tobias

Schuette

et al. 2020

Front. Behav. Neurosci.

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Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent literature lacks an overview of the major conceptual framework underlying anxiety research to introduce young researchers to the field. In this mini-review article, which is aimed toward new undergraduate and graduate students, we discuss how researchers exploit the approach-avoidance conflict, an internal conflict rodents face between exploration of novel environments and avoidance of danger, to inform rodent assays that allow for the measurement of anxiety-related behavior in the laboratory. We review five widely-used rodent anxiety assays, consider the pharmacological validity of these assays, and discuss neural circuits that have recently been shown to modulate anxiety using the assays described. Finally, we offer related lines of inquiry and comment on potential future directions.

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Section: Other Perspectivesmentioning

confidence: 99%

To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays

La-Vu

Tobias

Schuette

et al. 2020

Front. Behav. Neurosci.

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“…Female Flinders Sensitive Line (FSL) rats manifest an obvious depressive-like phenotype when undergoing treatment with selective serotonin reuptake inhibitors (SSRIs) [80]. Probiotics were found to reduce the risk-taking behavior in FSL rats with depression [81]. The Wistar Kyoto More Immobile (WMI) genetic model describes the independent pathological mechanisms for the environmental and genetic etiologies of depression [82].…”

Section: Depression Modeling Approachesmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

174

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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“…Used first as a model of cholinergicadrenergic hypothesis depression (233), they are now more generally used as a model of depression without comorbidity of anxiety and with a female predominance (234). The effect of the microbiota composition has been studied in those rats showing that their microbiota composition is different (235) and might represent a target to improve the depression phenotype (236). However, only a few studies have investigated the gastrointestinal features in those rats.…”

Section: Spontaneous Models Of Fgidmentioning

confidence: 99%

Animal Models for Functional Gastrointestinal Disorders

Accarie

Vanuytsel

2020

Front. Psychiatry

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Functional gastrointestinal disorders (FGID), such as functional dyspepsia (FD) and irritable bowel syndrome (IBS) are characterized by chronic abdominal symptoms in the absence of an organic, metabolic or systemic cause that readily explains these complaints. Their pathophysiology is still not fully elucidated and animal models have been of great value to improve the understanding of the complex biological mechanisms. Over the last decades, many animal models have been developed to further unravel FGID pathophysiology and test drug efficacy. In the first part of this review, we focus on stress-related models, starting with the different perinatal stress models, including the stress of the dam, followed by a discussion on neonatal stress such as the maternal separation model. We also describe the most commonly used stress models in adult animals which brought valuable insights on the brain-gut axis in stress-related disorders. In the second part, we focus more on models studying peripheral, i.e., gastrointestinal, mechanisms, either induced by an infection or another inflammatory trigger. In this section, we also introduce more recent models developed around food-related metabolic disorders or food hypersensitivity and allergy. Finally, we introduce models mimicking FGID as a secondary effect of medical interventions and spontaneous models sharing characteristics of GI and anxiety-related disorders. The latter are powerful models for brain-gut axis dysfunction and bring new insights about FGID and their comorbidities such as anxiety and depression.

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Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression

Cited by 29 publications

References 59 publications

To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays

To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays

Selecting an Appropriate Animal Model of Depression

Animal Models for Functional Gastrointestinal Disorders

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