The computational complexity of the multiple-input and multiple-output (MIMO) based least square algorithm is very high and it cannot be run on processing-inefficient low-cost platforms. To overcome complexity-related problems, a parallel distributed adaptive signal processing (PDASP) architecture is proposed, which is a distributed framework used to efficiently run the adaptive filtering algorithms having high computational cost. In this paper, a communication load-balancing procedure is introduced to validate the PDASP architecture using low-cost wireless sensor nodes. The PDASP architecture with the implementation of a multiple-input multiple-output (MIMO) based Recursive Least Square (RLS) algorithm is deployed on the processing-inefficient low-cost wireless sensor nodes to validate the performance of the PDASP architecture in terms of computational cost, processing time, and memory utilization. Furthermore, the processing time and memory utilization provided by the PDASP architecture are compared with sequentially operated RLS-based MIMO channel estimator on 2×2, 3×3, and 4×4 MIMO communication systems. The measurement results show that the sequentially operated MIMO RLS algorithm based on 3×3 and 4×4 MIMO communication systems is unable to work on a single unit; however, these MIMO systems can efficiently be run on the PDASP architecture with reduced memory utilization and processing time.