Production and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applications

Miguel, Sónia P.; Simões, Déborah; Moreira, André F.; Sequeira, Rosa Maria Saraiva; Correia, Ilídio J.

doi:10.1016/j.ijbiomac.2018.10.041

Cited by 127 publications

(99 citation statements)

References 56 publications

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“…excellent biological properties, not be free to stimulate migration and cell adhesion. 14 The fact that the membranes have been successfully crosslinked and have demonstrated no cytotoxicity against human keratinocytes is an excellent indication for this material to be used as a potential carrier for sustained drug release.…”

Section: Resultsmentioning

confidence: 99%

“…Electrospinning of the HA/PVA blend has already been reported with the use of surfactants or solvent mixtures. 14,15 However, to our knowledge, this is the rst study where no organic solvent or surfactant was used to prepare HA and PVA polymeric electrospinnable solutions (only water was used as a solvent), which reduces the toxicity of the nal material.…”

Section: Introductionmentioning

confidence: 99%

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Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes via electrospinning

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes via electrospinning

et al. 2020

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“…In terms of structure, the composite scaffold that contains a dense and waterproof electrospinning layer can protect the wound site in a similar way to the epidermis layer and a porous EHD jetting layer with good mechanical property can act as the dermis structure. [ 31,32 ] Among the biocompatible scaffold materials, polylactic acid (PLA) and PCL were widely used in tissue engineering through electrospinning or EHD jetting techniques because of their good mechanical and structural properties. [ 30,33,34 ] However, these materials present low bioactivity and hydrophobicity, which could reduce cell affinity and low tissue regeneration rates.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.

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“…In particular, silk fibroin and poly (caprolactone) were adopted for the top layer, while the bottom layer was prepared with fibroin and hyaluronic acid loaded with thymol as a herbal drug. The results demonstrated suitable features for wound healing application, in terms of biocompatibility, wettability and mechanical properties [ 90 ].…”

Section: Recent Advances On the Development Of Silk Fibroin-based mentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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Production and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applications

Cited by 127 publications

References 56 publications

Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes via electrospinning

Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes via electrospinning

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

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