Production and separation of 64Cu and 67Cu using 14 MeV neutrons

Kawabata, Masako; Hashimoto, Kazuhito; Saeki, Hideya; Sato, N.; Motoishi, Shoji; Takakura, Kei; Konno, Chikara; Nagai, Y.

doi:10.1007/s10967-014-3488-0

Cited by 20 publications

(14 citation statements)

References 18 publications

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“…In recent years some further efforts have been made to produce better quality 64 Cu via the above reaction in a nuclear reactor [70,71], in particular by using 99.4% enriched 64 ZnO as target material in a thermal neutron shielded sample holder and efficient separation methods for radiocopper [71]. Furthermore, accelerator produced neutrons have also been used, e. g. d(Be) break up neutrons [72] or MeV neutrons [73].…”

Section: Production Of 64 Cumentioning

confidence: 99%

“…The same threshold reaction has also been investigated with 14 MeV neutrons; however, by using a nat ZnO target [73]. A yet another method making use of the 68 Zn(n,np) 67 Cu reaction induced by fast neutrons, generated by breakup of 40 MeV deuterons on a graphite target, has also been utilized [108].…”

Section: Production Of 67 Cumentioning

confidence: 99%

“…A yet another method making use of the 68 Zn(n,np) 67 Cu reaction induced by fast neutrons, generated by breakup of 40 MeV deuterons on a graphite target, has also been utilized [108]. In those two works [73,108] the fundamental separation and purification procedures were established. The 67 Cu obtained via the latter process using a 99.29% enriched 68 ZnO target was shown to be suitable for preclinical studies [109].…”

Section: Production Of 67 Cumentioning

confidence: 99%

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New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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A brief historical background of the development of the theranostic approach in nuclear medicine is given and seven theranostic pairs of radionuclides, namely 44g Sc/ 47 Sc, 64 Cu/ 67 Cu, 83 Sr/ 90 Sr, 86 Y/ 90 Y, 124 I/ 131 I, 152 Tb/ 161 Tb and 152 Tb/ 149 Tb, are considered. The first six pairs consist of a positron and a β −-emitter whereas the seventh pair consists of a positron and an α-particle emitter. The decay properties of all those radionuclides are briefly mentioned and their production methodologies are discussed. The positron emitters 64 Cu, 86 Y and 124 I are commonly produced in sufficient quantities via the (p,n) reaction on the respective highly enriched target isotope. A clinical scale production of the positron emitter 44g Sc has been achieved via the generator route as well as via the (p,n) reaction, but further development work is necessary. The positron emitters 83 Sr and 152 Tb are under development. Among the therapeutic radionuclides, 89 Sr, 90 Y and 131 I are commercially available and 161 Tb can also be produced in sufficient quantity at a nuclear reactor. Great efforts are presently underway to produce 47 Sc and 67 Cu via neutron, photon and charged particle induced reactions. The radionuclide 149 Tb is unique because it is an α-particle emitter. The present method of production of 152 Tb and 149 Tb involves the use of the spallation process in combination with an on-line mass separator. The role of some emerging irradiation facilities in the production of special radionuclides is discussed.

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Section: Production Of 64 Cumentioning

confidence: 99%

Section: Production Of 67 Cumentioning

confidence: 99%

Section: Production Of 67 Cumentioning

confidence: 99%

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New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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“…Cu and 67 Cu produced by the 64 Zn(n,p) 64 Cu, 67 Zn(n,p) 67 Cu and 68 Zn(n,x) 67 Cu reactions using nat ZnO or 64 ZnO samples. 77) A flowchart of the separation steps of the irradiated samples is given in Fig. 19.…”

Section: Recovery Of An Irradiated 100 Moo 3 Samplementioning

confidence: 99%

Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons

Nagai

2021

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Interest has been growing in the development of medical radioisotopes used for noninvasive nuclear medicine imaging of disease and cancer therapy. Especially the development of an alternative production scheme of 99 Mo, the mother radioisotope of 99m Tc used for imaging, is required, because the current supply chain of the reactor product 99 Mo is fragile worldwide. We have proposed a new production scheme of 99 Mo as well as therapeutic radioisotopes, such as 64 Cu and 67 Cu, using accelerator neutrons provided by the nat C(d,n) reaction. Based on this scheme we have obtained high-quality 99m Tc, 64 Cu, and 67 Cu suitable for clinical use by developing both production and separation methods of the radioisotopes. We proposed a new facility to constantly and reliably produce a wide variety of high-quality, carrier-free radioisotopes, including 99 Mo, with accelerator neutrons. We report on the development of the proposed scheme and future prospects of the facility toward the domestic production of medical radioisotopes.

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“…Neutrons were generated via the C(d,n) reactions and a sample made of nat ZnO was irradiated by the neutrons. Note that the chemical form of ZnO was selected to dissolve easily by hydrochloride for the first step of chemical separation of copper from the irradiated sample by the solid phase extraction method [7]. The average beam current was 1 μA and the irradiation time was 4 hours.…”

Section: Proposal Of New Routes To Produce Radioisotopesmentioning

confidence: 99%

Development of Radioisotopes Production Method by Accelerator-Based Neutron: Activity at Kyushu University

Kin

Patwary

Kamida

et al. 2019

Proceedings of the Second International Symposium on Radiation Detectors and Their Uses (ISRD2018)

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We have studied Radioisotopes (RIs) production by the accelerator-based neutron method with neutrons generated via the (d,n) reaction on C or Be in the incident energy range less than 50 MeV. The study has been conducted by the two approaches: proposal of new production routes or new RIs with the accelerator-based neutron method and systematic measurements of double-differential thick-target neutron yields (DDTTNYs). In the study, we have proposed effective production methods of 64 Cu for a new PET RI and 92 Y for application of radio immunotherapy. Moreover, the DDTTNYs have been systematically measured by the multiple-foil activation method, and a new unfolding code with artificial neural network was developed for the unfolding process. In the present paper, our research activity and results are reviewed comprehensively to show examples of 64 Cu production and a TTNY measurement of C(d,n) reaction at 12-MeV deuteron.

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Production and separation of 64Cu and 67Cu using 14 MeV neutrons

Cited by 20 publications

References 18 publications

New developments in the production of theranostic pairs of radionuclides

New developments in the production of theranostic pairs of radionuclides

Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons

Development of Radioisotopes Production Method by Accelerator-Based Neutron: Activity at Kyushu University

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