Production of Anti-Rh in Guinea Pigs from Human Erythrocyte Extracts

A Review of Rh Serology and Presentation of a New Terminology

“…Difficulty in coping with the complexity of the Rh blood group system is not of recent origin, and is well illustrated by the history of Rho or D. As has been pointed out,48 the very name "Rh"z5 might not be used today had a prior report of Levine and Stetson33 in 1939 invoked a new term to describe an isoagglutinin of this specificity. Furthermore, data derived from absorption and elution studies28- [44][45] suggest that anti-rhesus serum does not cross-react with human Rho or D.…”

A ‘New’ Allele Giving Further Insight into the LW Blood Group System

“…The first clue to a difference between the two antibodies was observed by Fisk and Foord [3] in 1942, who found that the cells of all newborn babies, whether Rh positive or negative as defined by human anti-Rh, were positive with guin ea-pig anti-Rh. Subsequent work, initiated by Murray and Clark [4] [5][6][7]. The history and notation of LW is complex since the rare LW-negative pheno type can reflect a true genetical state or a transient acquired condition found during illness and antibody formation [for reviews see references [8][9][10].…”

Modern Concepts of the Blood Group Systems

“…However, it recently became quite clear that the antigen in human blood corresponding t o the true anti-Rhesus antibody is not the same as the clinically important antigen called Rho or D (Murray & Clark, 1952;Levine et al, 1961). But this realization came too late to change the name of the clinically important groups from Rh, for that name was in the title of perhaps a thousand papers.…”