Production of cationic 198Au3+ and nonionic 198Au0 for radionuclide therapy applications via the natAu(n,γ)198Au reaction

Sadeghi, Mahdi; Jabal-Ameli, Hamidreza; Ahmadi, Seyed Javad; Sadjadi, Sodeh; Bakht, Martin

doi:10.1007/s10967-012-1772-4

Cited by 13 publications

(1 citation statement)

References 15 publications

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“…Back in those days however, poor control over particle synthesis (relatively large Au particles, broad size distributions) was clearly identified as a major limitation . With the advent of nanotechnology, it is now possible to control the size of particles, as well as to perform very precise and in‐depth materials science characterization studies, at unprecedented resolutions, sensitivities, and with very small quantities of materials . Hence, there has recently been a resurgence of interest for radioactive Au NPs applied to tumor treatment for modern brachytherapy procedures.…”

Section: Resultsmentioning

confidence: 99%

Low‐Dose Prostate Cancer Brachytherapy with Radioactive Palladium–Gold Nanoparticles

Laprise-Pelletier

Lagueux

Côté

et al. 2017

Adv Healthcare Materials

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Prostate cancer (PCa) is one of the leading causes of death among men. Low-dose brachytherapy is an increasingly used treatment for PCa, which requires the implantation of tens of radioactive seeds. This treatment causes discomfort; these implants cannot be removed, and they generate image artifacts. In this study, the authors report on intratumoral injections of radioactive gold nanoparticles (Au NPs) as an alternative to seeds. The particles ( Pd:Pd@Au-PEG and Pd:Pd@ Au:Au-PEG; 10-14 nm Pd@Au core, 36-48 nm hydrodynamic diameter) are synthesized by a one-pot process and characterized by electron microscopy. Administrated as low volume (2-4 µL) single doses (1.6-1.7 mCi), the particles are strongly retained in PCa xenograft tumors, impacting on their growth rate. After 4 weeks, a tumor volume inhibition of 56% and of 75%, compared to the controls, is observed for Pd:Pd@Au-PEG NPs and Pd:Pd@ Au:Au-PEG NPs, respectively. Skin necrosis is observed with Au; therefore, Au NPs labeled with Pd only are a more advisable choice. Overall, this is the first study confirming the impact of Pd@Au NPs on tumor growth. This new brachytherapy procedure could allow tunable doses of radioactivity, administered with smaller needles than with the current technologies, and leading to fewer image artifacts.

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Section: Resultsmentioning

confidence: 99%