Production of microparticles from milk fat products using the Supercritical Melt Micronization (ScMM) process

Lubary, Marta; Loos, Theo W. de; Horst, Joop H. ter; Hofland, Gerard W.

doi:10.1016/j.supflu.2010.10.010

Cited by 24 publications

(7 citation statements)

References 17 publications

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“…The exciting role of supercritical fluid technology in particle formation has attracted interest in recent years (Fahim et al, ; Lubary et al, ; Ubeyitogullari and Ciftci, ; Yang and Ciftci, ). Carbon dioxide (CO 2 ) is the most common supercritical fluid because it has mild critical temperature and pressure (31°C, 74 bar), and it is nontoxic, nonflammable, environmentally friendly, inexpensive, and safe.…”

Section: Introductionmentioning

confidence: 99%

“…Carbon dioxide (CO 2 ) is the most common supercritical fluid because it has mild critical temperature and pressure (31°C, 74 bar), and it is nontoxic, nonflammable, environmentally friendly, inexpensive, and safe. Previously, micron size solid lipid particles were generated using particle from gas‐saturated solutions (PGSS) or gas‐assisted melting atomization (GAMA) methods (Bertucco et al, ; García‐González et al, ; Lubary et al, ; Mandžuka and Knez, ; Sampaio de Sousa et al, ). Lubary et al () used a similar process called supercritical melt micronization to form and collect the particles from nonchemically modified low‐melting lipids, namely, anhydrous milk fat and a diacylglycerol‐based modified milk fat.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, micron size solid lipid particles were generated using particle from gas‐saturated solutions (PGSS) or gas‐assisted melting atomization (GAMA) methods (Bertucco et al, ; García‐González et al, ; Lubary et al, ; Mandžuka and Knez, ; Sampaio de Sousa et al, ). Lubary et al () used a similar process called supercritical melt micronization to form and collect the particles from nonchemically modified low‐melting lipids, namely, anhydrous milk fat and a diacylglycerol‐based modified milk fat. A potential challenge of that method was the development and maintenance of a low‐temperature environment in the sample collection vessel, which could be resource intensive on an industrial scale.…”

Section: Introductionmentioning

confidence: 99%

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Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Gudeman

Yang

Ciftci

2018

J Americ Oil Chem Soc

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The use of solid fats is challenging due to difficulty in incorporating into foods, handling during industrial food production, and relatively high-calorie contributions. The objective of this study was to form free-flowing and low-density hollow microparticles from nonhydrogenated fats, namely, butter and fractionated palm oil, using a novel method based on atomization of a carbon dioxide (CO 2 )expanded lipid mixture. The melting point of the fractionated palm oil decreased from 66.2 to 47.3 C above 120 bar in the presence of pressurized CO 2 . The density of the particles decreased fivefolds compared to that of the original oils. The average particle size D [4,3] decreased from 67.0 to 27.1 μm when the concentration of fractionated palm oil was increased from 50% to 100%. The hollow structure was more pronounced for the particles obtained from higher melting oils/oil blends, as well as with more spherical uniformity. Ten percent (d 10% ) and 50% (d 50% ) of the palm oil particles were smaller than 4.5 and 23.0 μm, respectively, whereas they were 14.5 and 58.3 μm when mixed with butter at 50% butter concentration, respectively. Polymorphic form of α was more pronounced in the solid lipid particles, indicating that they had a less-ordered crystalline structure than the original oil. This new method forms low-density and free-flowing lipid powders that make the handling and storage of solid lipids feasible and convenient, and may provide reduced fat usage and calorie intake, and more rapid oil melting in mouth.Keywords Fractionated palm oil Á Butter Á Hollow solid lipid particle Á Supercritical carbon dioxide Á Melting J Am Oil Chem Soc (2019) 96: 147-158.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Gudeman

Yang

Ciftci

2018

J Americ Oil Chem Soc

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“…The CO 2 gas then leaves the gas-saturated polymer/fat droplets and also during expansion, the temperature of the mixture reduces drastically due to the Joule–Thomson effect, hence causing the polymer solidification [88]. A similar process termed as supercritical melt micronization (ScMM) has been developed for the micronization of fats (such as hard fats or milk fats) [89,90,91,92]. For microencapsulation application, the PGSS process can be used for water-soluble active ingredients and coating materials.…”

Section: Role Of Supercritical Carbon Dioxide In Microencapsulatiomentioning

confidence: 99%

Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques

Soh¹,

Lee²

2019

Pharmaceutics

108

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The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2), provide numerous opportunities for the development of processes for pharmaceutical applications. One of the potential applications for pharmaceuticals includes microencapsulation and nanoencapsulation for drug delivery purposes. Supercritical CO2 processes allow the design and control of particle size, as well as drug loading by utilizing the tunable properties of supercritical CO2 at different operating conditions (flow ratio, temperature, pressures, etc.). This review aims to provide a comprehensive overview of the processes and techniques using supercritical fluid processing based on the supercritical properties, the role of supercritical carbon dioxide during the process, and the mechanism of formulation production for each process discussed. The considerations for equipment configurations to achieve the various processes described and the mechanisms behind the representative processes such as RESS (rapid expansion of supercritical solutions), SAS (supercritical antisolvent), SFEE (supercritical fluid extraction of emulsions), PGSS (particles from gas-saturated solutions), drying, and polymer foaming will be explained via schematic representation. More recent developments such as fluidized bed coating using supercritical CO2 as the fluidizing and drying medium, the supercritical CO2 spray drying of aqueous solutions, as well as the production of microporous drug releasing devices via foaming, will be highlighted in this review. Development and strategies to control and optimize the particle morphology, drug loading, and yield from the major processes will also be discussed.

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“…Among the available techniques for SLN production by supercritical fluid processing, particles from gas-saturated solutions (PGSS) have been shown as the most interesting. Also known as supercritical melt micronization process [ 86 ], PGSS is a completely solvent-free process where a solid is melted in a highly pressurized vessel pressurized by a compressed gas. Figure 11 demonstrates a generic scheme of a PGSS plant used for drug-loaded polymeric and lipid particles.…”

Section: Reviewmentioning

confidence: 99%

Characteristics of lipid micro- and nanoparticles based on supercritical formation for potential pharmaceutical application

et al. 2013

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The interest of the pharmaceutical industry in lipid drug delivery systems due to their prolonged release profile, biocompatibility, reduction of side effects, and so on is already known. However, conventional methods of preparation of these structures for their use and production in the pharmaceutical industry are difficult since these methods are usually multi-step and involve high amount of organic solvent. Furthermore, some processes need extreme conditions, which can lead to an increase of heterogeneity of particle size and degradation of the drug. An alternative for drug delivery system production is the utilization of supercritical fluid technique. Lipid particles produced by supercritical fluid have shown different physicochemical properties in comparison to lipid particles produced by classical methods. Such particles have shown more physical stability and narrower size distribution. So, in this paper, a critical overview of supercritical fluid-based processes for the production of lipid micro- and nanoparticles is given and the most important characteristics of each process are highlighted.

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Production of microparticles from milk fat products using the Supercritical Melt Micronization (ScMM) process

Cited by 24 publications

References 17 publications

Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques

Characteristics of lipid micro- and nanoparticles based on supercritical formation for potential pharmaceutical application

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