Production of Oligospermia in a Man by the Use of Testosterone Propionate.

Heckel, Norris J.

doi:10.3181/00379727-40-10527p

Cited by 58 publications

(18 citation statements)

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“…Since a high concentration of testicular T is known to be required for normal spermatogenesis, we conclude that the cause of the depression of spermatogenesis in men given TP is the striking reduction in testicular T. (/ Clin Endocrinol Metab 37: 882, 1973) T HE administration of testosterone (T) to normal men causes a large reduction in sperm concentration (1,2,3), and in plasma LH, but only a slight or moderate (maximum of 50%) change in plasma FSH (4)(5)(6)(7)(8).…”

mentioning

confidence: 93%

Testosterone Concentrations in Testes of Normal Men: Effects of Testosterone Propionate Administration

Morse

Horike

Rowley

et al. 1973

The Journal of Clinical Endocrinology & Metabolism

100

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Testicular and plasma testosterone (T) and plasma LH levels were determined in 6 normal men. Two of these men received 50 mg testosterone propionate (TP) daily for 10 and 25 weeks, respectively. Testicular and plasma T and plasma LH assays were again performed during TP administration. The mean T concentration for 5 control testicular biopsies was 553 ng/g ± 90 SD, which was approximately 100 times higher than average normal plasma T concentrations (assuming 1 ml plasma s 1 g tissue). Administration of TP resulted in the following: 1) LH was rapidly reduced to undetectable levels; 2) testicular T decreased by about 95%; 3) plasma T increased nearly 2-fold; and 4) sperm concentration dropped sharply.Since a high concentration of testicular T is known to be required for normal spermatogenesis, we conclude that the cause of the depression of spermatogenesis in men given TP is the striking reduction in testicular T. (/ Clin Endocrinol Metab 37: 882, 1973) T HE administration of testosterone (T) to normal men causes a large reduction in sperm concentration (1,2,3), and in plasma LH, but only a slight or moderate (maximum of 50%) change in plasma FSH (4-8).In a previous publication (5) we suggested that the inhibition of spermatogenesis by androgen administration to normal men might occur as a result of a markedly reduced testicular T concentration rather than a lack of plasma FSH. If the normal testicular T concentration is far higher than the normal plasma T level, because of local secretion by Leydig cells, then administration of testosterone propionate (TP) could decrease testicular T while simultaneously increasing plasma T.To test this hypothesis, it was decided to examine T concentrations in testicular biopsies and plasma of normal men before, during and after administration of TP. Materials and Methods Subjects and administrationSix healthy volunteers ranging in age from 24 to 47 yr served as subjects. Their average sperm concentration ranged from 62 to 140 million/ml

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mentioning

confidence: 93%

Testosterone Concentrations in Testes of Normal Men: Effects of Testosterone Propionate Administration

Morse

Horike

Rowley

et al. 1973

The Journal of Clinical Endocrinology & Metabolism

100

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“…It has been known for almost 70 yr that the chronic administration of testosterone to a man suppresses sperm production (212). Because the administration of testosterone alone fails to completely suppress sperm production in some men, progestogens or GnRH antagonists have been combined with testosterone to further suppress pituitary gonadotropins and improve its contraceptive efficacy.…”

Section: Male Hormonal Contraceptive Methodsmentioning

confidence: 99%

Advances in Male Contraception

2008

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“…In 1939, two investigators independently tested testosterone for suppression of spermatogenesis. 33,34 Since then, female birth control pills have dominated the contraceptive market. It has been difficult to equal or improve on the safety, efficacy and reversibility of female birth control pills, as the bar has been set quite high.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

“…In 1939, independent studies on male contraception were performed by Heckel 33 and McCullagh and McGurl 34 and with short-acting testosterone propionate. Subsequent studies revealed reversible azoospermia by 60 days in some patients with daily use of 25 mg i.m.…”

Section: Testosterone Alonementioning

confidence: 99%

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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Traditionally, male contraception has consisted of either barrier methods, such as condoms, or vasectomy. However, in recent years, we have made great strides in the basic science and clinical medicine to better understand the feedback mechanisms and physiology of the male reproductive system. These advances have enabled the development of several nonsurgical, hormonal, reversible, well-tolerated alternatives for male contraception. Men are more likely now than ever to participate in the choice of contraceptive techniques. This review will discuss the current status and recent developments in nonsurgical hormonal male contraception, a field that has been historically limited by social, financial and physiological challenges.

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Production of Oligospermia in a Man by the Use of Testosterone Propionate.

Cited by 58 publications

References 0 publications

Testosterone Concentrations in Testes of Normal Men: Effects of Testosterone Propionate Administration

Testosterone Concentrations in Testes of Normal Men: Effects of Testosterone Propionate Administration

Advances in Male Contraception

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

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