Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound

In Vitro Metabolism of 5-ALA Esters Derivatives in Hairless Mice Skin Homogenate and in Vivo PpIX Accumulation Studies

“…Improved delivery systems for 5-ALA to the skin may play an important role in the success of PDT in dermatology. Enhancement of 5-ALA skin penetration can be achieved either by varying vehicle composition (7), adding the penetration enhancers (8), or by physical methods such as iontophoresis (9,10) and ultrasound (11).…”

Drug Delivery of Aminolevulinic Acid from Topical Formulations Intended for Photodynamic Therapy¶

“…Although tissue damage is a potential outcome, ultrasound has been shown to induce or enhance the delivery of molecules across the plasma membranes of cells in vitro without loss of viability (143-145). Ma et al (146) proposed that ultrasound could increase the low intrinsic blood circulation in tumors (147), resulting in a relatively selective 0 II uptake of drugs into these cellular masses. The authors showed an increase of 4.5% in the amount of PpIX produced by transplanted human adenocarcinoma tumors in mice after 1-2 h following ultrasound treatment.…”

Drug Delivery of Aminolevulinic Acid from Topical Formulations Intended for Photodynamic Therapy¶

“…Although tissue damage is a potential outcome, ultrasound has been shown to induce or enhance the delivery of molecules across the plasma membranes of cells in vitro without loss of viability (143–145). Ma et al (146) proposed that ultrasound could increase the low intrinsic blood circulation in tumors (147), resulting in a relatively selective uptake of drugs into these cellular masses. The authors showed an increase of 45% in the amount of PpIX produced by transplanted human adenocarcinoma tumors in mice after 1–2 h following ultrasound treatment.…”