Production of Reactive Oxygen Species by Peripheral Blood Phagocytic Cells of Premature Newborns in the Early Neonatal Period

Zhukova, A. S.; Nikitina, I. V.; Van'ko, L. V.; Matveeva, N. K.; Кречетова, Л. В.; Ionov, Ionov O.V.; Timofeeva, L. A.; Зубков, В. В.; Degtyarev, D.N.; Сухих, Г. Т.

doi:10.1055/s-0036-159240

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amid the background of a yet immature immune system, the synthesis of cytokines and immunoglobulins decreases in the foetus, resulting in intrauterine infection. The main factor in the development of intrauterine infection and the cause of neonatal morbidity and death is a decrease in the ability to synthesise proinflammatory cytokines [2,3]. The gestation age of newborns has an important influence on the qualitative and quantitative parameters of cytokines.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections

et al. 2021

View full text Add to dashboard Cite

Intrauterine infections are an urgent problem of modern neonatology. One of the causes of intrauterine infective foetal lesions is physiological immunosuppression. The purpose of this study is to investigate the cytokine status in newborns infected with perinatal infections, depending on their body weight. The study examined 145 newborns. Taking into account their body weight, they were divided into 2 groups: main and secondary. The study was conducted in the immunological laboratory of the Medical Centre of Marat Ospanov West Kazakhstan Medical University in the city of Aktobe, with the determination of the level of IgM and IgG to the herpes simplex virus (HSV) types 1, 2, cytomegalovirus (CMV), and chlamydia using the MULTISKANASCENT analyser with the "Chemo" T system. The main results of this study are the predominance of the anti-inflammatory component in both normal weight and underweight infants, which is evidence of the Th-cell-mediated immune response prevalence. The applied value of this study lies in the possibility of applying its results in practice to obtain effective methods to counteract the occurrence and development of intrauterine infections.

show abstract

Section: Introductionmentioning

confidence: 99%