Introduction. The specifics of the professional activity of medical workers in the context of the COVID-19 pandemic, in the presence of stressful factors of production situations, negatively affects the professional profile of specialists and leads to the opportunity of a professional crisis. Purpose. To identify the features of the profile of the professional crisis of medical workers with professional deformities in the context of the COVID-19 pandemic. Materials and methods. The study conducted on 816 medical workers with occupational deformities included questionnaires on the personality profile of the crisis by A.E. Taras and on burnout by C. Maslach & S. Jackson, K. Pearson’s correlation criterion, descriptive statistics and Chaddock’s table to reveal the tightness of correlation processes. Results. The main features of the profile of the professional crisis of medical workers with deformities in the professional field include a high level of functional disorders of cardiac activity and the activity of the gastrointestinal tract; functional disorders of breathing, autonomic system, thinking, sleep; symptoms of anxiety and increased emotionality; attempts to escape from problems, and depressive mood coloring. Limitations. When studying the characteristics of the profile of the professional crisis, a psychodiagnostic study was conducted using the author’s methods on a sample of 816 voluntarily participating medical workers with professional deformities in the context of the COVID-19 pandemic, which is a sufficient reference sample. Conclusion. In the context of the COVID-19 pandemic, the grading of deformations in the professional field of medical workers will contribute to: normalization of the activity of the autonomic, respiratory and cardiovascular systems, and the gastrointestinal tract; harmonization of the sleep-wake cycle; reduction of depression, attempts to escape from problems, tension, complications of thinking, anxiety.