Profile of antimicrobial potential of fifteen Hypericum species from Portugal

Nogueira, Teresa; Medeiros, M. A.; Marcelo‐Curto, M. J.; Garcı́a-Pérez, Blanca Estela; Luna-Herrera, Julieta; Costa, María do Céu

doi:10.1016/j.indcrop.2013.03.005

Cited by 29 publications

(16 citation statements)

References 34 publications

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“…Little is known about the antimicrobial activity of H. perfoliatum: in particular, a recent study of Nogueira et al (2013) reported the analysis of 15 Hypericum species from Portugal for their antimicrobial activities; H. perfoliatum resulted one of the most active extract against S. aureus at the dose of 6 g/mL. Also in our case, the extracts of the plant, with the exception of methanolic one, are active against the same bacterium.…”

Section: Bacillus Cereus 4313mentioning

confidence: 60%

Phenolic content, antimicrobial and antioxidant activities of Hypericum perfoliatum L.

Monte

Martino

Marandino

et al. 2015

Industrial Crops and Products

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Section: Bacillus Cereus 4313mentioning

confidence: 60%

Phenolic content, antimicrobial and antioxidant activities of Hypericum perfoliatum L.

Monte

Martino

Marandino

et al. 2015

Industrial Crops and Products

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“…Hypericum species (Hypericaceae family; nearly about 450 species) are examples of these plants, being Hypericum perforatum L. the most widely known and with attributed anti-depressive, anti-inflammatory, antitumor, antimicrobial, antioxidant and antiviral benefits (Nogueira et al, 2013;Rainha, Lima, & Baptista, 2011;Ramalhete et al, 2016). However, based on recent findings, other Hypericum species have also revealed very interesting functional properties.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to highlight that no reports have been found evaluating its anti-inflammatory potential, which is of utmost importance once inflammation is not only a consequence of the free radicals overproduction, but also a cause of numerous disorders, such as neurodegenerative and cardiovascular diseases, and even cancer (Valko et al, 2007). Regarding antimicrobial effects, those were only described for ethanol extracts obtained from the aerial parts (Nogueira et al, 2013). In fact, opportunistic fungal infections constitute a serious threat to human health and wellbeing (Lott, Fundyga, Kuykendall, & Arnold, 2005), and for many years, Candida albicans has been designated as the most widespread involved opportunistic pathogenic yeast (Guinea, 2014).…”

Section: Introductionmentioning

confidence: 99%

Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

Jabeur

Tobaldini

Martins

et al. 2016

Food Research International

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Hypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. A marked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lines was also observed, whereas no toxicity was shown against non-tumor porcine liver cells (>400μg/mL). The extract was also effective in inhibiting nitric oxide production, as an indicator of the anti-inflammatory potential. The anti-Candida effects varied among different strains of the same species, C. glabrata and C. tropicalis being the most sensible species with an effect directly related with the extract concentrations tested. A significant anti-biofilm formation potential was also observed, namely for C. glabrata and C. tropicalis (biofilm reduction >90%). 5-O-Caffeoylquinic and 3-O-caffeoylquinic acids were the most abundant phenolic compounds identified in the extract, and might be related with the observed bioactive effects. Nevertheless, future studies should be carried out to obtain dose-response curves of the isolated active compounds, in order to perform further pre-clinically testing to quantify the presence of the most active compounds in the extract.

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“…This phenomenon could explain the great variation observed in content of compounds among the species as well as their different tissues. Among the Hypericum species investigated in the present study, H. calycinum is a well-known medicinal plant with its fixed antimicrobial (Nogueira et al 2013), antifungal, antimalarial (Decosterd et al 1991) and antioxidant (Kirmizibekmez et al 2009) activities. Especially, its antidepressant effect could be of interest which was detected as potent as that of H. perforatum, the officinal species used in the treatment of mild to moderate depression (Oztürk et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Secondary metabolites of sevenHypericumspecies growing in Turkey

Çırak

Radušienė

Jakštas

et al. 2016

Pharmaceutical Biology

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Context The genus Hypericum (Hypericaceae) has attracted remarkable scientific interest as its members have yielded many bioactive compounds. Objective The current study presents investigations on the accumulation of hypericin, pseudohypericin, hyperforin, adhyperforin, chlorogenic acid, neochlorogenic acid, caffeic acid, 2,4-dihydroxybenzoic acid, 13,118-biapigenin, hyperoside, isoquercitrin, quercitrin, quercetin, avicularin, rutin, (+)-catechin and (-)-epicatechin in seven Hypericum (Hypericaceae) species growing wild in Turkey, namely, H. aviculariifolium Jaup. and Spach subsp. aviculariifolium (Freyn and Bornm.) Robson var. albiflorum (endemic), H. bithynicum Boiss., H. calycinum L., H. cardiophyllum Boiss., H. elongatum L. subsp. microcalycinum (Boiss. and Heldr.) Robson, H. hirsutum L. and H. xylosteifolium (Spach) N. Robson. Materials and methods The plant materials were collected at flowering period and dissected in different tissues. Air-dried plant material including stems, leaves and flowers was mechanically powdered with a laboratory mill and samples (0.1 g) were extracted in 10 mL of 100% methanol by ultrasonication at 40 °C for 30 min for HPLC-PDA analyses. Results Accumulation levels of the investigated compounds varied greatly depending on species and plant part. Discussion For the first time, the detailed chemical profiles of corresponding Turkish Hypericum species were reported and the results were discussed from a phytochemical point of view. Conclusions The present data have importance in evaluation of plant resources of Hypericum genus in selecting the new potential sources of bioactive compounds.

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Profile of antimicrobial potential of fifteen Hypericum species from Portugal

Cited by 29 publications

References 34 publications

Phenolic content, antimicrobial and antioxidant activities of Hypericum perfoliatum L.

Phenolic content, antimicrobial and antioxidant activities of Hypericum perfoliatum L.

Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

Secondary metabolites of sevenHypericumspecies growing in Turkey

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