A 55-year-old Saudi Arabian female presented with a 3-year history of progressive dyspnea on exertion and paroxysmal nocturnal dyspnea. Examination showed a mitral systolic and diastolic murmur. A clinical diagnosis of left atrial myxoma was established by noninvasive as well as invasive investigations. A tumor measuring 5 x 3 cm was removed and the diagnosis was confirmed by histology. Following surgery, the patient became asymptomatic and the electrocardiogram, chest radiograph, and echocardiogram were normal after 1 year. The review of the literature focuses on the differential diagnosis and management of left atrial myxoma. ME Fawzy, G Ziady, N Feteih, J Heibig, A Beall, Diagnosis and Management of Left Atrial Myxoma. 1983; 3(1): 59-65