Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus

Zhu, Yanan; Tian, Fei; Li, Hailing; Zhou, Youxia; Lu, Jiafeng; Ge, Qinyu

doi:10.1016/j.ijgo.2015.01.010

Cited by 151 publications

(193 citation statements)

References 26 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…Measurement of serum PlGF at 11-14 weeks improves the performance of early screening for GDM (Eleft heriades et al 2014). Yilmaz and colleagues have suggested also the neutrophil-to-lym-phocyte ratio (NLR) as an independent predictor of GDM development (Zhu et al 2015). Finally, in the next future, miRNA expressed in GDM could serve as earlier predictive markers (Zhu et al 2015).…”

Section: Diagnosismentioning

confidence: 99%

“…Yilmaz and colleagues have suggested also the neutrophil-to-lym-phocyte ratio (NLR) as an independent predictor of GDM development (Zhu et al 2015). Finally, in the next future, miRNA expressed in GDM could serve as earlier predictive markers (Zhu et al 2015). In particular, Dicer and Drosha are the two major enzymes in the miRNA biogenesis process with evidence of up-regulation in GDM patients (Rahimi et al 2015).…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Gestational diabetes: An overview with attention for developing countries

Schiavone

Putoto

et al. 2016

Endocrine Regulations

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is defi ned as a glucose intolerance that occurs for the fi rst time or it is fi rst identifi ed during pregnancy. Th e GDM etiology is multifactorial. It has not completely been established yet and several known risk factors may contribute to its onset. To date, there are no shared guidelines on the management and follow-up, especially regarding the lowincome countries. In this paper, we describe the state of art about epidemiology, physiopathology, diagnosis, and management of GDM. Moreover, we focus on the current state in low income countries trying to outline basis for further research.

show abstract

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Gestational diabetes: An overview with attention for developing countries

Schiavone

Putoto

et al. 2016

Endocrine Regulations

View full text Add to dashboard Cite

show abstract

“…• Association between levels of some miRNAs and markers of microvascular impairment revealed the dysregulation of some in the serum and plasma of women who went on to develop GDM compared with the controls [43,44]. These results suggest that circulating miRNAs could be used as biomarkers for the early diagnosis or as a predictive factor for GDM.…”

Section: Circulating Mirnas As Early Predictive Biomarkers Of Diabetesmentioning

confidence: 89%

“…Furthermore, the miRNA content of different types of blood cells were also deregulated in type 1 and type 2 diabetic patients compared with controls [38][39][40][41][42]. Finally, analysis of circulating miRNAs in women with gestational diabetes mellitus has revealed that in both serum and plasma some miRNAs have an altered profile compared with those in control women [43,44].…”

Section: Circulating Mirnas As Biomarkers Of the Diabetic Conditionmentioning

confidence: 95%

Circulating microRNAs and diabetes: potential applications in medical practice

et al. 2015

View full text Add to dashboard Cite

The explosive increase in the worldwide prevalence of diabetes over recent years has transformed the disease into a major public health concern. While diabetes can be screened for and diagnosed by reliable biological tests based on blood glucose levels, by and large there are no means of detecting at-risk patients or of following diabetic complications. The recent discovery that microRNAs are not only chief intracellular players in many biological processes, including insulin secretion and action, but are also circulating, has put them in the limelight as possible biological markers. Here we discuss the potential role of circulating microRNAs as biomarkers in the context of diabetes and its associated complications.

show abstract

“…A kezelés korai megkezdése megelőzheti a szövődmények kialakulását. Erre alkalmasak a miRNSmolekulák, amelyek anyai vérből már a 12. héten kimutatók, például a miR- 16, miR-17, miR-19a, miR-19b és miR-20 [26].…”

Section: A Mirnsunclassified

A „szabad” nukleinsavak jelentősége a noninvazív diagnosztikában

2016

View full text Add to dashboard Cite

Napjainkban nagy az érdeklődés a "szabad" nukleinsavak pontos élettani szerepének és klinikai diagnosztikai felhasználásának a meghatározására. A "szabad" nukleinsavak lehetnek DNS-, mRNS-, mikro-RNS-és hosszú nem kódoló RNS-(lncRNNA-) molekulák, amelyek megtalálhatók a testfolyadékokban, így például a szérumban, a nyálban, a könnyben. Az élettani szerepük kiderítése napjainkban is folyik, viszont egyre jelentősebb a diagnosztikai alkalmazhatóságuk. A magzati diagnosztikában a noninvazív módon történő mintavétel után nyert "szabad" DNS-t felhasználva több tesztet forgalomba hoztak, ezek specificitása és szenzitivitása eléri a 99,9%-ot. A szív-és keringési betegek korai diagnosztizálásában a "szabad" nukleinsavak meghatározása biztató eredményekkel szolgál. Az onkológiában a "folyadékbiopsziával" kapcsolatos közlemények megjelenése a más területen dolgozó egészségügyi szakemberek és a közvélemény figyelmét is felkeltette. Folynak a mikro-RNS szerepének és diagnosztikai alkalmazhatóságának a meghatározásai is. A "szabad" nukleinsavak új generációs szekvenálással történő felhasználására a korai diagnosztikában óriási az érdeklődés, de egyelőre nincs elég klinikai adat a lehetséges tesztek megbízhatóságáról és klinikai hasznossá-gáról. Orv. Hetil., 2016Hetil., , 157(48), 1900Hetil., -1909 Kulcsszavak: "szabad" nukleinsavak, DNS, mRNS, mikro-RNS, folyadékbiopszia, diagnosztika The importance of "free" nucleic acids in the non-invasive diagnosticsThere is a great interest to determine the physiological role of "free" nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiological processes is still in the focus of the research, while their use in the diagnostics is becoming more and more important. The use of "free" DNA in the non-invasive prenatal diagnosis is the first clinical application of the new generation sequencers, these methods are able to reach 99.9% specificity and sensitivity for the detection of the most common trisomies. There are promising results in their use in the diagnosis and classification of heart and cardiovascular diseases. In oncology the possibility to use the "liquid biopsy" captured the attention of not only researchers and clinicians, but the whole community. There is not enough data until today for the clinical utility and applicability of these methods.Keywords: "free" nucleic acids, DNA, mRNA, microRNA, liquid biopsy, diagnostics Nagy, B., Csanádi, Z., Póka, R. [The importance of "free" nucleic acids in the non-invasive diagnostics]. Orv. Hetil., 2016, 157(48), 1900-1909. (Beérkezett: 2016 elfogadva: 2016. október Rövidítések AMI = akut myocardialis infarctus; CNA = copy number gain; CRP = C-reaktív protein; CRT = szívreszinkronizációs terápia; ctDNS = keringő tumor-DNS; DNS = dezoxiribonukleinsav; EF = ejekciós frakció; HDL = high-density lipoprotein; LDL = low-density lipoprotein; lncRNA = (...

show abstract

Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus

Abstract: The five miRNAs that were differentially expressed in GDM could serve as noninvasive biomarkers. The results also provide insights into the molecular mechanisms that underlie GDM, thereby contributing to the diagnosis and treatment of this disease.

Cited by 151 publications

References 26 publications

Gestational diabetes: An overview with attention for developing countries

Gestational diabetes: An overview with attention for developing countries

Circulating microRNAs and diabetes: potential applications in medical practice

A „szabad” nukleinsavak jelentősége a noninvazív diagnosztikában

Contact Info

Product

Resources

About