Progesterone: The Key Factor of the Beginning of Life

Bulletti, Carlo; Bulletti, Francesco Maria; Sciorio, Romualdo; Guido, Maurizio

doi:10.3390/ijms232214138

Cited by 30 publications

(15 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, progesterone may exert a protective function in supporting pregnancy up to birth. Progesterone vaginal administration is currently the most widely used treatment for luteal phase support (LPS) for assisted reproductive technology …”

Section: Resultsmentioning

confidence: 99%

“…Progesterone vaginal administration is currently the most widely used treatment for luteal phase support (LPS) for assisted reproductive technology. 100 We have then considered amoxicillin and salbutamol that according to the European Guidelines provided by the EMA 101 and the FDA 102 belong to the most widely prescribed ATC classification drugs, anti-infectives (J-ATC) and respiratory (R-ATC), respectively. As shown in Figures 6 and 7, the Dev Tox safe/unsafe molecular moieties are green/red-contoured, respectively.…”

Section: Tisbementioning

confidence: 99%

See 1 more Smart Citation

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity

Mastrolorito,

Togo,

Gambacorta

et al. 2024

Chem. Res. Toxicol.

View full text Add to dashboard Cite

Despite being extremely relevant for the protection of prenatal and neonatal health, the developmental toxicity (Dev Tox) is a highly complex endpoint whose molecular rationale is still largely unknown. The lack of availability of high-quality data as well as robust nontesting methods makes its understanding even more difficult. Thus, the application of new explainable alternative methods is of utmost importance, with Dev Tox being one of the most animal-intensive research themes of regulatory toxicology. Descending from TIRESIA (Toxicology Intelligence and Regulatory Evaluations for Scientific and Industry Applications), the present work describes TISBE (TIRESIA Improved on Structure-Based Explainability), a new public web platform implementing four fundamental advancements for in silico analyses: a three times larger dataset, a transparent XAI (explainable artificial intelligence) framework employing a fragment-based fingerprint coding, a novel consensus classifier based on five independent machine learning models, and a new applicability domain (AD) method based on a double top-down approach for better estimating the prediction reliability. The training set (TS) includes as many as 1008 chemicals annotated with experimental toxicity values. Based on a 5-fold cross-validation, a median value of 0.410 for the Matthews correlation coefficient was calculated; TISBE was very effective, with a median value of sensitivity and specificity equal to 0.984 and 0.274, respectively. TISBE was applied on two external pools made of 1484 bioactive compounds and 85 pediatric drugs taken from ChEMBL (Chemical European Molecular Biology Laboratory) and TEDDY (Task-Force in Europe for Drug Development in the Young) repositories, respectively. Notably, TISBE gives users the option to clearly spot the molecular fragments responsible for the toxicity or the safety of a given chemical query and is available for free at .

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Tisbementioning

confidence: 99%

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity

Mastrolorito,

Togo,

Gambacorta

et al. 2024

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

“…In which β-hCG was considered as the most important. Previous research revealed that serum levels of β-hCG plays a key role in predicting clinical pregnancy in IVF cycles [19,20]. Undoubtedly, β-hCG is essential for the maintained of pregnancy.…”

Section: Hormones Involved In Regulating Uterine Changes During Place...mentioning

confidence: 99%

Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study

Wu,

Xiao,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background How to accurately predicting the pregnancy outcomes of an IVF cycle are particularly important. Although a lot of work was conducted to predict pregnancy outcomes by assaying serum β-hCG levels after embryo transfer, rare study has focused on the prediction of serum E2 level after transfer. This study sought to analyze the predictive effect of serum E2 combined with β-hCG on early reproductive outcomes 12 days after embryo transfer. Methods A total of 1521 patients with β-hCG positive values on day 12 after frozen-warmed embryo transfer (FET) in natural endometrial preparation cycles (NCs) were collected in affiliated Women’s Hospital of Jiangnan University. Logistic regression analysis was constructed to establish the clinical pregnancy prediction model, and the cutoff value, optimal sensitivity and specificity were calculated by Receiver operating characteristic (ROC). Results Levels of serum E2 and β-hCG on the 12th day after FET with NCs were higher in clinical pregnancy group (CP Group) compared with biochemical pregnancy group (BP Group) (P < 0.001). Besides, the cutoff values for E2 and β-hCG on the 12th day after FET with NCs in cleavage group (CE Group) were 129.25 pg/mL and 156.60 mIU/mL respectively, with area under the ROC curve (AUC) of 0.801 and 0.941 respectively. For blastocyst group (B Group), the cutoff values for E2 and β-hCG were 174.45 pg/mL and 217.70 mIU/mL, with AUCs of 0.762 and 0.924 respectively. The logistic regression analysis revealed that serum E2 day 12 and β-hCGday 12 were significantly associated with clinical pregnancy. Conclusions Serum E2 is significantly different in CP Group compared with BP Group in FET with NCs. Earlier E2 combined with β-HCG can be used as a predictor of early pregnant state.

show abstract

“…In women of childbearing age, the growth of the ovarian follicles, ovulation, and the corpus luteum formation is accompanied by the cyclic secretion of estrogen and progesterone, which ultimately causes the cyclic shedding of the endometrium and bleeding. 12,53,54 This phenomenon is called menstruation. Menstruation usually occurs once a month, and the menstrual cycle begins on the day of the first visible bleeding (day 1).…”

Section: The Menstrual Cycle and Stable Endometrial Repair And Regene...mentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

View full text Add to dashboard Cite

The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

show abstract

Progesterone: The Key Factor of the Beginning of Life

Cited by 30 publications

References 188 publications

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity

Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Contact Info

Product

Resources

About