Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invaison Pattern: A Retrospective Study

Okçu, Oğuzhan; Askan, Gokce; Şen, Bayram; Öztürk, Çiğdem; Öztürk, Seda Duman; Güvendi, Gülname Fındık

doi:10.4274/mmj.galenos.2022.40336

MMJ

2022

DOI: 10.4274/mmj.galenos.2022.40336

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Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invaison Pattern: A Retrospective Study

Oğuzhan Okçu¹,

Gokce Askan²,

Bayram Şen³

et al.

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Cited by 4 publications

(1 citation statement)

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“…We read with a great deal of interest the article entitled “Prognostic Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study” by Okcu et al 1 .…”

mentioning

confidence: 99%

Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies

IAVAZZO¹,

FOTIOU²,

GKEGKES³

et al. 2022

MMJ

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mentioning

confidence: 99%

Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies

IAVAZZO¹,

FOTIOU²,

GKEGKES³

et al. 2022

MMJ

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Enhancing prognostic insights: myometrial invasion patterns in endometrial carcinoma, with emphasis on MELF pattern–a comprehensive review and meta-analysis

Guo,

Li,

Yang

et al. 2024

European Journal of Cancer Prevention

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Purpose The microcystic, elongated, and fragmented (MELF) pattern, characterized by myxoid and inflamed stroma, is readily identifiable as a form of myometrial infiltration. This meta-analysis endeavors to assess the prognostic significance of MELF infiltration patterns in patients diagnosed with endometrial cancer. Methods A comprehensive literature search, spanning until 11 October 2023, across PubMed, Embase, Cochrane, and Web of Science databases, identified 23 relevant studies involving 5199 patients. Data analysis was performed using Stata 16.0. Results Analysis indicates that MELF infiltration predicts a higher risk of lymph node metastasis in endometrial cancer patients [hazard ratios (HR) = 5.05; 95% confidence interval (CI), 3.62–7.05; P < 0.05]. Notably, this association remains consistent across various patient demographics, analytical approaches, study designs, and treatment modalities. However, MELF infiltration does not significantly correlate with recurrence (HR = 1.05; 95% CI, 0.73–1.52; P > 0.05), overall survival (HR = 1.24; 95% CI, 0.91–1.68; P > 0.05), or disease-free survival (HR = 1.40; 95% CI, 0.85–2.28; P > 0.05). Conclusion While MELF infiltration heightens the risk of lymph node metastasis in endometrial cancer, its impact on recurrence, overall survival, and disease-free survival remains statistically insignificant.

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Molecular classification and adjuvant treatment in endometrioid endometrial cancer with microcystic elongated and fragmented (MELF) invasion pattern

Jia,

Zhang

2024

BMC Women's Health

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Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invaison Pattern: A Retrospective Study

Cited by 4 publications

References 55 publications

Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies

Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies

Enhancing prognostic insights: myometrial invasion patterns in endometrial carcinoma, with emphasis on MELF pattern–a comprehensive review and meta-analysis

Molecular classification and adjuvant treatment in endometrioid endometrial cancer with microcystic elongated and fragmented (MELF) invasion pattern

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