Prognostic Factors and Causes of Death in Patients Cured of Esophageal Cancer

Kakuta, Tomoyuki; Kosugi, Shin‐ichi; Kanda, Tatsuo; Ishikawa, Takashi; Hanyu, Takaaki; Suzuki, Tsutomu; Wakai, Toshifumi

doi:10.1245/s10434-014-3499-7

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…24 In addition, we identified pulmonary diseases as the most common cause of death in patients cured of esophageal cancer after esophagectomy. 25 The present study found that RF is deteriorated even at the late phase after esophagectomy and supports the findings of our previous studies. Unfortunately, we could not identify the risk factors for the deterioration of RF at the late phase after esophagectomy.…”

Section: Discussionsupporting

confidence: 93%

Long-Term Trends in Respiratory Function After Esophagectomy for Esophageal Cancer

Ichikawa

Hanyu

Ishikawa

et al. 2020

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 93%

Long-Term Trends in Respiratory Function After Esophagectomy for Esophageal Cancer

Ichikawa

Hanyu

Ishikawa

et al. 2020

Journal of Surgical Research

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“…4 The strongest prognostic factor is tumour stage, the 5-year survival is 65% for stage I, 27% for stage II and 9% for stage III. 4 Other prognostic factors are older age, 86,87 higher hospital volume and surgeon volume. 6, 88 Figure 6.…”

Section: Mortalitymentioning

confidence: 99%

Comorbidities and Risk of Complications After Surgery for Esophageal Cancer: A Nationwide Cohort Study in Sweden

et al. 2015

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“…In this sense, it is difficult to know whether these patients can be considered “cured” of their disease. 8,9 Here we report data on survival and recurrence in patients with LAEC surviving at least 5 years after resection, as well as other causes of death in this highly selected patient population. Because we assumed that patients with early-stage disease are highly likely to be cured of EC, 10 we focused on patients with locally advanced disease treated with either esophagectomy alone or preoperative therapy followed by resection.…”

Section: Discussionmentioning

confidence: 95%

Locally advanced esophageal cancer: What becomes of 5-year survivors?

Ghaly¹,

Kamel²,

Nasar³

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

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Objective To determine the long-term outcomes of patients with locally advanced esophageal cancer (LAEC) who underwent esophagectomy and survived at least 5 years, and the predictors of disease-free survival (DFS) beyond 5 years. Methods This was a retrospective review of a prospective database to identify patients with clinical stage T2N0M0 or higher LAEC. Medical records were reviewed to obtain demographic, clinical, and pathological characteristics, as well as data on recurrence and survival. Multivariable analysis of predictors of DFS beyond 5 years was performed using a Cox regression model. Results Between 1988 and 2009, 355 of 500 patients underwent esophagectomy for cT2N0M0 or higher disease. Of these 355 patients, 126 were alive and disease-free at the 5-year follow-up, for an actuarial 5-year DFS of 33%. Recurrent esophageal cancer developed in 8 patients after 5 years. Among the 126 surviving patients, the actuarial overall survival was 94% at 7 years and 80% at 10 years. On multivariable analysis, the sole significant predictor of DFS after the 5-year time point was non–en bloc resection at the original operation (P = .006). Pulmonary-related deaths accounted for 10 out of 22 noncancer deaths. A second primary cancer developed in 23 of the 126 surviving patients. Conclusions Prolonged survival can be obtained in one-third of patients with LAEC. An en bloc resection at the original operation is the most significant predictor of prolonged survival. Survivors experience a high rate of second primary cancer and an apparently high rate of deaths from pulmonary disease. Careful follow-up is necessary for these patients, even after the 5-year mark.

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Prognostic Factors and Causes of Death in Patients Cured of Esophageal Cancer

Abstract: Careful follow-up including the surveillance of other primary cancers is required for long-term survivors of esophageal cancer after esophagectomy.

Cited by 16 publications

References 27 publications

Long-Term Trends in Respiratory Function After Esophagectomy for Esophageal Cancer

Long-Term Trends in Respiratory Function After Esophagectomy for Esophageal Cancer

Comorbidities and Risk of Complications After Surgery for Esophageal Cancer: A Nationwide Cohort Study in Sweden

Locally advanced esophageal cancer: What becomes of 5-year survivors?

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