Prognostic Factors in Pulmonary Metastases from Colorectal Cancer

Zapatero, J.; Flandes, J.; Lago, J.; Devesa, Manuel; Golpe, Antonio

doi:10.1159/000196352

Cited by 8 publications

(1 citation statement)

References 11 publications

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“…The 51 included series had mid-point dates from 1965 to 2000 and included a total of 3504 patients (Figure 2). 4 , 6 , 7 11, 12, 13, 14, 15 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58 The presence of data pertaining to each of the specified domains in each of the 51 papers is indicated by a bar in Figure 3. Where data were present for a particular domain they were often inconsistently reported, with various definitions and summary statistics.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary metastasectomy in colorectal cancer: a systematic review and quantitative synthesis

et al. 2010

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SummaryObjectives Surgical removal of pulmonary metastases from colorectal cancer is undertaken increasingly but the practice is variable. There have been no randomized trials of effectiveness. We needed evidence from a systematic review to plan a randomized controlled trial.Design A formal search for all studies concerning the practice of pulmonary metastasectomy was undertaken including all published articles using pre-specified keywords. Abstracts were screened, reviewed and data extracted by at least two of the authors. Information across studies was collated in a quantitative synthesis. ResultsOf 101 articles identified, 51 contained sufficient quantitative information to be included in the synthesis. The reports were published between 1971 and 2007, and reported on 3504 patients. There was little change over time in patient characteristics such as age, sex, the time elapsed since resection of the primary cancer, its site or stage. The proportion with multiple metastases or elevated carcinoma embryonic antigen (CEA) did not change over time but there was an apparent increase in the proportion of patients who also had hepatic metastasectomy. Differences in 5-year survival between groups defined by CEA or by single versus multiple metastases persisted over time. Few data were available concerning postoperative morbidity, postoperative lung function or change in symptoms. ConclusionThe quality of evidence available concerning pulmonary metastasectomy in colorectal cancer is not sufficient to draw inferences concerning the effectiveness of this surgery. There is great variety in what was reported and its utility. Given the burdensome nature of the surgery involved, better evidence, ideally in the form of a randomized trial, is required for the continuance of this practice.

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