Prognostic relevance of aberrations in the erbB oncogenes from breast, ovarian, oral and lung cancers: Double-differential polymerase chain reaction (ddPCR) for clinical diagnosis

Cancer genes alterations and HPV infection in oral squamous cell carcinoma

“…60% of tumours harboured p53 mutations, which agrees with previous reports 14,39 . 95% of mutations in p53 occur within highly conserved regions (exons [5][6][7][8]. The present study showed a higher frequency of mutations in exons 7 and 8 (60%) than in 5 and 6, which is in line with data published by CHAVES et al 8 .…”

Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa

“…[35][36][37][38] These receptors cooperate in promoting cell growth and in inhibiting the differentiation of breast cancer cell lines; 37,38 increased copy number of the erb B1-B2-B3 genes positively correlates with lymph node metastasis in breast, oral, and ovarian cancer. 35 Moreover, overexpression of all members of the type I receptor family was detected in papillary carcinoma of the thyroid, in comparison with its normal counterpart. 36 Nevertheless, the role of such growth factor receptors as prognostic parameters in patients with common human malignancies has not been fully explored.…”

Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas

“…Reports of one group showed an increased copy number of the HER2 gene (17q11) in oral cavity HNSCC (Brandt et al, 1995;Werkmeister et al, 1996;2000). In addition, several studies have demonstrated increased HER2/ERBB2 oncoprotein levels (Werkmeister et al, 1996;Ibrahim et al, 1999;Xia et al, 1999).…”