Prognostic significance of Gleason score 7 (3+4) and Gleason score 7 (4+3) in prostatic adenocarcinoma in relation to clinical stage, androgen tissue status and degree of neuroendocrine differentiation

Mijović, Milica; Vukićević, Danica; Đerković, B.; Nedeljković, V.; Vitković, Leonida

doi:10.5937/pramed1401001m

Praxis Med

2014

DOI: 10.5937/pramed1401001m

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Prognostic significance of Gleason score 7 (3+4) and Gleason score 7 (4+3) in prostatic adenocarcinoma in relation to clinical stage, androgen tissue status and degree of neuroendocrine differentiation

Milica Mijović¹,

Danica Vukićević²,

B. Đerković³

et al.

Abstract: Prognoza i izbor terapije adenokarcinoma prostate (ADKP) direktno zavise od brojnih prediktivnih faktora, među kojima su najznačajniji zbirni histološki gradus tumora (Gleason score, koji predstavlja zbir prvog i drugog dominantnog histološkog gradusa) i klinički stadijum. Novija istraživanja u ove faktore ubrajaju i tkivni androgen status i neuroendokrinu diferencijaciju. Važnost prvog i drugog dominantnog histološkog gradusa naročito postaje značajan kod ADKP Gleason score-a 7. Smatra se da goru prognozu ima… Show more

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Cited by 2 publications

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Clinical-morphological characteristics of pathological changes in the prostate

Ilić¹,

Denović²

2018

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The most significant prostate diseases (PD) are benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate cancer (PC). Generally, all PD are rare before the age of 50 with growing number of patients, primarily with BHP, with each next decade, but about decade later the highest number of PIN and PC began to report. The aim of this paper is to examine some of clinical, biochemical and histopathological characteristics of BPH, PIN and PC. Our sample consisted of 169 men. Statisticaly the most common PD was BPH-77.5%, and the rarest PIN-8.3% (p<0.001). The average age of patients was 70.6±7.5 years (51-89) with no significant differences between diagnosis (p=0.415). PIN and PC are more often found in people from urban areas (p=0.004). In the central prostate area BPH is significantly higher in 88.5% (p<0.001). Peripheral parts are significantly more common places of PIN and PC (p<0.001). Median serum PSA values is statistically highest in PC-87.2 ng/ml (12.7-372.5), (p<0,001), especially those with predominantly peripheral parts localization. Gleason score is an important prognostic factor, with average value at PC is 7.32±1.4 (5-10), with a significantly higher values for diffuse PC. BPH is the most common, and PIN rarest PD. All diseases have occurred in people older than 50 years. Usually, BPH is in central and PIN and PC in peripheral prostate parts. PSA values were highest at PC, which is a prove of its importance in malignancy early detection.

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Clinical-morphological characteristics of pathological changes in the prostate

Ilić¹,

Denović²

2018

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Diagnostic, prognostic and predictive parameters in prostate cancer

Mijović¹,

Nedeljković²,

Vukićević³

et al. 2019

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Prostate cancer (CP) is the most common malignancy in men in America, while it is the second most common in Europe. It is responsible for about 10% of cancer deaths in the same population. It is clinically manifested in various forms, from slow-growing to aggressive forms with pronounced metastatic potential. Diagnosis is made by a well-defined algorithm, which begins with the determination of serum prostate specific antigen values and ends with prostate biopsy as the "gold standard". Pathohistological diagnostic criterias are based on architectural, cytoplasmic, nuclear and characteristics of intraluminal structures, as well as periacinar cleftings, which are deffined as helpfull diagnostic criteria of undoubted importance. Prognostic and predictive parameters are classified into three categories. Some of them are an integral part of routine pathohistologicat report, while others are considered as the diagnostic process progresses. Modern knowledge introduces biomarkers into the everyday practice of personalized medicine, especially when is necessary to treat prostate cancer patients.

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Prognostic significance of Gleason score 7 (3+4) and Gleason score 7 (4+3) in prostatic adenocarcinoma in relation to clinical stage, androgen tissue status and degree of neuroendocrine differentiation

Cited by 2 publications

References 42 publications

Clinical-morphological characteristics of pathological changes in the prostate

Clinical-morphological characteristics of pathological changes in the prostate

Diagnostic, prognostic and predictive parameters in prostate cancer

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