Prognostic Significance of Immunohistochemically Localized Biomarkers in Stage II and Stage III Breast Cancer: A Multivariate Analysis

Jm, Bhatavdekar; Patel, Devendra D.; Shah, Neelam G.; Vora, Hemangini H.; Suthar, Tejal P.; Chikhlikar, Priya R.; Ghosh, Nandita; Trivedi, Trupti

doi:10.1007/s10434-000-0305-5

Cited by 54 publications

(34 citation statements)

References 23 publications

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“…The percentage positivity of p53 immunohistochemistry of the present study is almost similar to the reported statistics of most of the studies [14,20,[22][23][24][25][26] except, it is high in studies done by Bhatavdekar et al, [25] and Silvestrini et al, [26]. In maximum number of studies the average percentage of p53 positivity in breast cancers ranges from 18% to 36% [13].…”

Section: Discussionsupporting

confidence: 88%

Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Radha¹

2014

JCDR

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Introduction: Cancer of the breast is one of the commonest carcinomas in women, both in western world and in India. The high frequency of breast cancer in women has prompted an intensive study of possible modifiable risk factors (clinical parameters, morphological typing, and biological markers) for assessment of prognosis, prevention strategies, and treatment modalities. p53 is one of the most significant prognostic markers for breast carcinomas.

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Section: Discussionsupporting

confidence: 88%

Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Radha¹

2014

JCDR

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“…In this regard, our results are in contrast with studies that suggest that bcl-2 expression is a favourable prognostic factor when primary surgical therapy is used. In other studies bcl-2 expression has been found to be an independent predictor of prognosis (7,8,12,10,18,38). However, other studies have shown opposite results (6,25,35,36,47).…”

Section: Discussionmentioning

confidence: 77%

Expression of Bcl-2 in Breast Cancer: Correlation with Clinicopathological Characteristics and Survival

Čečka

Hornychová

Melichar

et al. 2008

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Breast cancer is the most common malignancy in women. It is an immensely heterogeneous disease, characterised by a broad variety of clinical development. The research in recent years has focused on finding new markers of prognosis. This study investigates the role of expression of the bcl-2 protein in breast cancer. We analysed bcl-2 expression in 57 women with primary breast carcinoma who were treated with neoadjuvant (primary) chemotherapy, followed by a surgical procedure. The bcl-2 expression was correlated with other clinicopathological characteristics of the tumour -histological grade, stage, expression of hormonal receptors, proliferation rate, and with the survival of the patients. No significant association of bcl-2 expression with either overall survival or disease free survival was found.

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“…Alterations in the proto-oncogene HER-2/neu have been extensively studied in Western and east Asian females with breast cancer and proposed as prognostic markers of potential clinical utility [11][12][13][14][15][16][17]. However, few studies exist on prognostic signifi cance of these oncogenes in female breast cancer in developing countries particularly in India [18].…”

Section: Introductionmentioning

confidence: 99%

Significance of Her-2/neu protein over expression in Indian breast cancer patients

et al. 2007

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Background Racial disparity in presentation and outcome of breast cancer is established but cause is unexplained . Many studies show various molecular markers for racial differences in the prognosis of breast cancer. There is scarcity of data on prognostic signifi cance of HER-2/neu in Indian breast cancer. Aims and ObjectiveTo know incidence and prognostic signifi cance of HER-2/neu expression in Indian patients.To correlate HER-2/neu Expression with other prognostic markers and ER/PR Receptor status. Statistical Analysis Data was analyzed by univariate and multivariate analysis for all prognostic factors. Signifi cance was calculated by using Chi square test and survival analysis by using Kaplan Meier survival curve. Material and MethodsResults The median age of 112 patients was 46.56 (±9.55) years. HER-2/neu over expression was present in 46.37%. Signifi cant correlation was found between HER-2/neu over expression and lymph node status, grade of tumor and ER/ PR receptor status. Median follow up period of 23 months. There was signifi cant tumour free survival advantage (p < 0.01) and overall survival advantage (p < 0.001) in patients with HER-2/neu negative expression.Conclusion HER-2/neu oncogene over expression is higher (46.37%) among Indian patients in comparison to 25-30% shown in most western literature. HER-2/neu oncogene over expression signifi cantly correlates with grade, lymph node involvement, ER/PR status and also affects survival.

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Prognostic Significance of Immunohistochemically Localized Biomarkers in Stage II and Stage III Breast Cancer: A Multivariate Analysis

Cited by 54 publications

References 23 publications

Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Histopathology and Prognostic Indices of Carcinoma Breast with Special Reference to p53 Marker

Expression of Bcl-2 in Breast Cancer: Correlation with Clinicopathological Characteristics and Survival

Significance of Her-2/neu protein over expression in Indian breast cancer patients

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