Prognostic Significance of Serum Uric Acid in Patients Admitted to the Department of Medicine

Wasserman, Asaf; Shnell, Matti; Boursi, Ben; Guzner-Gur, Hanan

doi:10.1097/maj.0b013e3181bbb647

Cited by 30 publications

(14 citation statements)

References 33 publications

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“…[14][15][16][17] UA is a product of purine metabolism that is produced by xanthine oxidase. [18] Xanthine oxidase activity and the that patients with anterior MI, prolonged chest pain, older age, and hyperuricemia were at a higher risk for mortality and/or advanced severe heart failure during the in-hospital period and that these patients should be given intensive medical therapy and referred to a center where invasive treatment is available.…”

Section: Discussionmentioning

confidence: 99%

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

Gazı

Temız

Altun

et al. 2014

Arch Turk Soc Cardiol

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Section: Discussionmentioning

confidence: 99%

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

Gazı

Temız

Altun

et al. 2014

Arch Turk Soc Cardiol

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“…It is becoming apparent that UA homeostasis and its relationship with health and disease is complex. Elevated serum UA is associated with hypertension (HTN), as well as with diabetes, cardiovascular disease, endothelial dysfunction, obesity, metabolic syndrome, nephrolithiasis, intellectual disabilities, and all-cause mortality (1)(2)(3)(4)(5)(6)(7)(8). On the other hand, some recent investigations provide evidence that UA may be beneficial as an antioxidant/freeradical scavenger in certain patient groups (9)(10)(11).…”

mentioning

confidence: 99%

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

et al. 2012

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“…Как следствие этих про-цессов, гиперурикемия сопряжена с неблагоприятным ге-модинамическим профилем: высоким давлением в лёгочной артерии, сниженными сердечным индексом, ФВ ЛЖ, ко-ронарным кровотоком и выраженной митральной регур-гитацией [26][27][28]. В последние годы в литературе появи-лось достаточно большое количество исследований, рас-сматривающих гиперурикемию в роли маркера неблаго-приятного прогноза больных с ХСН [29,30].…”

Section: Risk Factors Of Chf Decompensation / факторы риска декомпенсunclassified

“…In recent years a lot of studies have been published, considering hyperuricemia as a marker of poor prognosis in CHF patients [29,30].…”

Section: Risk Factors Of Chf Decompensation / факторы риска декомпенсmentioning

confidence: 99%

Factors Effecting the Decompensation of Chronic Heart Failure in the Elderly

Ларина¹,

Барт²,

Vartanyan³

2013

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To identify risk factors of decompensation of chronic heart failure (CHF) and related hospitalization in elderly outpatients. Material and methods. The total of 248 patients aged 60-85 years with CHF NYHA class II-IV were enrolled into the study. The first group consisted of 87 (35.1%) patients who required hospitalization due to CHF decompensation during the follow-up, the second group -of 161 patients without need for hospital admission. All the patients had undergone clinical and laboratory examination, estimation of CHF severity by the Scale of clinical state, assessment of quality of life and 6-minute walk test (6MWT), echocardiography. Results. Patients were matched for age, gender, disability occurrence, education level, body mass index, quality of life, hemodynamic parameters, incidence rates of anemia, diabetes mellitus and atrial fibrillation. CHF was more severe in patients who had required hospitalization (p<0.001), they were more often diagnosed with left ventricular aneurysm (p=0.001), chronic kidney disease (p=0.001), left ventricular ejection fraction (LVEF)<35% (p<0.001), history of stroke (p<0.001), III-IV degree mitral regurgitation (p=0.007), hyperuricemia (p<0.001), lower exercise tolerance (p=0.007) compared with patients without hospitalization. Higher functional class of CHF (OR=0.29; 95% CI 0.13-0.69; p=0.003), LVEF<35% (OR 0.37; 95% CI 0.18-0.76; p=0.007), chronic kidney disease (OR=0.29; 95% CI 0.13-0.68; p=0.004) and hyperuricemia (OR=0.23; 95%CI 0.10-0.50; p<0.001) were shown to be independent risk factors of CHF decompensation that required hospital admission in elderly patients. Conclusuion. High FC of CHF, low LVEF, hyperuricemia and renal dysfunction play a key role in CHF decompensation and related hospitalization in elderly patients. Key words: chronic heart failure, hospitalization, elderly patients. Цель. Выявить факторы, повышающие риск декомпенсации хронической сердечной недостаточности (ХСН) и связанных с ней госпитализаций у пожилых больных, наблюдаю-щихся в поликлинических условиях. Материал и методы. В исследование были включены 248 больных в возрасте от 60 до 85 лет с ХСН II-IV функционального класса (ФК) по NYHA. Первую группу составили 87 (35,1%) больных, которым в процессе наблюдения потребовалась госпитализация в связи с декомпенсацией ХСН, вторую группу составил 161 больной, не нуждавшийся в ней. Всем больным проводили клинико-лабораторное обследование, оценивали тяжесть ХСН по шкале оценки клинических состояний, качество жизни, осуществляли тест с 6-минутной ходьбой, эхокардиографию. Результаты. Больные двух групп были сопоставимы по возрасту, полу, наличию инвалидности, уровню образования, индексу массы тела, качеству жизни, гемодинамическим по-казателям, частоте встречаемости анемии, сахарного диабета и фибрилляции предсердий. Течение ХСН было более тяжёлое у больных, которым потребовалась госпитализация (р<0,001), у них чаще выявлялись аневризма левого желудочка (ЛЖ) (р=0,001), хроническая болезнь почек (ХБП) (р=0,001), фракция выброса левого желудочка (Ф...

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Prognostic Significance of Serum Uric Acid in Patients Admitted to the Department of Medicine

Cited by 30 publications

References 33 publications

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

Factors Effecting the Decompensation of Chronic Heart Failure in the Elderly

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