Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Lin, Gigin; Jiang, Xiaomei; Peng, Jingyi; Xiao, Jie; Li, Dongying; Xia, Zhong‐Jun

doi:10.7314/apjcp.2014.15.15.6387

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…The circulating level of monocytes in the peripheral blood is reported to reflect the formation and/or presence of TAMs (45). Therefore, an increased level of monocytes reflects a high tumor burden in patients with cancer (53–55). However, in the present study, AMC was not considered a prognostic factor for the OS rate using multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

Hong

Chen

et al. 2017

Oncology Letters

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The inflammatory microenvironment serves an important function in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory biomarker combining an estimate of host immune homeostasis with the tumor microenvironment, has been identified to be a predictor of clinical outcomes in a number of malignancies. The present study aimed at investigating the prognostic value of LMR in patients with hepatitis B virus (HBV)-associated advanced HCC. A total of 174 patients with HBV-associated advanced HCC, without fever or signs of infections, were analyzed. Clinicopathological parameters, including LMR, were evaluated to identify predictors of overall survival time. Univariate and multivariate analysis was performed using Cox's proportional hazards model. A threshold value was determined using a time-dependent receiver operating characteristic curve. Univariate and multivariate analysis identified LMR as an independent prognostic factor in overall survival (OS) time in patients with HBV-associated advanced HCC (P<0.05). The threshold value of LMR was 2.22. All patients were divided into either a low LMR group (≤2.22) or a high LMR group (>2.22). The OS time of the high LMR group was significantly longer compared with the low LMR group (P<0.001). Patients in the high LMR group exhibited a significantly increased 3-month and 6-month OS rate, compared with that of the patients within the low LMR group (P<0.001). An increased level of LMR was significantly associated with the presence of metastasis, ascites and increased tumor size (P<0.01). LMR is an independent prognostic factor of HBV-associated advanced HCC patients and an increased baseline LMR level indicates an improved prognosis.

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Section: Discussionmentioning

confidence: 99%

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

Hong

Chen

et al. 2017

Oncology Letters

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“…After thoroughly screening the titles and abstracts by two investigators independently, the full‐texts of 173 potential studies were selected for further identification. Finally, 102 retrospective studies and 2 retrospective‐prospective studies from 93 eligible papers that met the inclusion criteria were included in this meta‐analysis 22–24,30–119 . The flow diagram of the selection procedure is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

Wen

Chen

et al. 2021

Cancer Medicine

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“…Furthermore, epidemiologic studies have shown that an elevated CRP level in apparently healthy individuals can be a marker of high potential risk of certain types of cancer and that a high CRP level in cancer patients indicates a risk of earlier death by cancer [17]. PBMCs have also been linked to cancer prognosis [18]. Thus, while CRP tests act as the first-line screening for various infectious and inflammatory diseases as well as cancer and cardiovascular conditions, combining CRP detection with WBC or PBMC count and further cell analysis may lead to an improved diagnosis and prognosis.…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

Combined detection of C-reactive protein and PBMC quantification from whole blood in an integrated lab-on-a-disc microfluidic platform

Uddin

Donolato²,

Hwu

et al. 2018

Sensors and Actuators B: Chemical

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Highlights  A biosensing platform to concurrently detect CRP and PBMC from single blood sample  The microfluidic chip/disc and the readout units are integrated in a single platform  The entire assay procedure is automated from sample to answer  The biosensor needs low sample volume and low sample-to-answer time  It has potential characteristics to be implemented as an out-of-lab setting

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Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Cited by 8 publications

References 33 publications

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

Combined detection of C-reactive protein and PBMC quantification from whole blood in an integrated lab-on-a-disc microfluidic platform

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