Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Luo, Jinwen; Duan, Weijia; Yu, Yanqiao; Song, Lei; Shi, Dazhuo

doi:10.3389/fcvm.2021.774781

Cited by 30 publications

(26 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The triglyceride-glucose (TyG) index, calculated as ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2), has become a valuable biomarker for insulin resistance [3]. Previous studies have shown that the TyG index was associated with cardiovascular events [4]. For instance, the TyG index was associated with the prevalence of coronary artery disease (CAD) [5] and an increased risk of ischemic stroke [6], hypertension [7], and arterial stiffness [8].…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and carotid atherosclerosis detected by ultrasonography

Chen

Tao

et al. 2022

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Several previous studies have indicated that the triglyceride-glucose index (TyG) index is associated with carotid atherosclerosis (CA); however, the evidence of the association is limited and inconsistent, which may result from small sample sizes or differences in study populations. Therefore, we examined the relation between the TyG index and CA in a large general population of Chinese middle-aged and elderly population. Methods A total of 59,123 middle-aged and elderly participants were enrolled. The TyG index was calculated as ln[fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2]. Logistic regression models were used to analyze the relationship between the TyG index as continuous variables and quartiles and CA. The relationships between the TyG index and CA according to sex, age groups, blood pressure groups and body mass index groups were also assessed. Results The multivariate logistic regression analysis showed that the TyG index was significantly associated with the prevalence of CA (OR: 1.48; 95% CI 1.39–1.56), carotid intima-media thickness (CMT) (1.55; 1.45–1.67), plaques (1.38; 1.30–1.47) and stenosis severity (> 50%) (1.33; 1.14–1.56). Compared with the quartile 1, quartile 4 was significantly associated with a higher prevalence of CA (1.59; 1.45–1.75), CMT (1.93; 1.82–2.18), plaques (1.36; 1.22–1.51) and stenosis severity (> 50%) (1.56; 1.20–2.04). Subgroup analyses showed significant associations between the continuous TyG index and the prevalence of CA, CMT, plaques and stenosis severity (> 50%) according to sex, with a higher prevalence of CA, CMT, and plaques among males, while a higher prevalence of stenosis severity in females (> 50%). For participants aged < 60 years old and with hypertension, the relationship between the TyG index and stenosis severity (> 50%) was not observed (1.47; 0.97–2.22 and 1.13; 0.91–1.41). For body mass index (BMI), the association was just observed among overweight participants (1.48; 1.17–1.86). In addition, similar results were also observed when the TyG index was used as a categorical variable. Conclusions There is a positive association between the TyG index and CA. The association is higher in males and middle-aged individuals than those in females and elderly individuals. Besides, the relationship is stronger among individuals with normal blood pressure and underweight subjects.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and carotid atherosclerosis detected by ultrasonography

Chen

Tao

et al. 2022

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…In some aspects, TyG is even more effective than the HOMA-IR model, especially in predicting metabolic syndrome, and arterial stiffness [7,8]. And several studies have demonstrated that the TyG index can predict myocardial infarction, stroke or other adverse cardiovascular events [9][10][11]. However, no studies have investigated the relationship between the TyG index and cardiovascular events in CTO patients.…”

Section: Introductionmentioning

confidence: 99%

The predictive value of the triglyceride—glucose index for cardiovascular events in patients with coronary chronic total occlusion

et al. 2022

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Chronic total occlusion (CTO) of the coronary artery is a difficult problem in clinical practice. The triglyceride–glucose (TyG) index is an effective risk predictor of cardiovascular risk. However, the relationship between the TyG index and the prognosis of CTO patients remains unstudied. Thus, the present study aimed to investigate the relationship between the TyG index and cardiovascular risk in CTO patients. Methods This was a single-centre, retrospective cohort study. We retrospectively enrolled 652 patients with CTO lesions diagnosed by angiography and who underwent revascularization through PCI. Patients were routinely followed up for 24 months unless meeting the endpoint. The primary endpoint was the composite of all-cause death, nonfatal myocardial infarction, unplanned revascularization, and nonfatal ischaemic stroke. To test the association of the TyG index with cardiovascular risk, the categorized TyG index and Cox proportional hazards regression models were utilized. Results A total of 652 patients were enrolled in the final analysis (male: 83.7%, age: 58.2 ± 10.49 years). The average TyG index was 8.8 ± 0.57. CTO PCIs were procedurally successfully completed in 503 (77.15%) patients. During the follow-up period of 22.8 ± 3.84 months, 73 (11.19%) major adverse cardiovascular and cerebral events (MACCEs) occurred. When fully adjusted, there was a 2.09-fold risk for MACCEs among patients with the highest TyG index compared with those with the lowest TyG index [T2 vs. T1: hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.65–2.38, P = 0.057; T3 vs. T1: HR 2.09, 95% CI 1.14–3.86, P = 0.018; P for trend = 0.036]. The restricted cubic spline (RCS) analysis showed that the HR for MACCEs increased as the TyG index increased over 8.71 [HR per standard deviation (SD) 1.740, 95% CI 1.23–2.46, P = 0.002]. The risk of MACCEs increased with increasing tertiles of TyG index in successful CTO PCI patients and nondiabetes mellitus (DM) patients (P < 0.05) but not in patients with failed CTO PCI and DM patients. Conclusion The study revealed that the TyG index had significant relevance to cardiovascular risk in CTO patients and suggests that the TyG index is feasible for predicting cardiovascular risk in CTO patients.

show abstract

“…Based on the serum levels of glucose and triglyceride, we identified that the TyG index was a predictor of 6-month readmission in HF patients. The elevated TyG index is a predictive factor of adverse cardiovascular events in myocardial infarction with nonobstructive coronary arteries [ 14 ], coronary artery disease [ 8 ], hypertension [ 7 ], and chronic heart failure [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the triglyceride glucose (TyG) index was confirmed to be a surrogate marker of insulin resistance [ 6 ]. Previous studies demonstrated that TyG index was of prognostic value in patients with hypertension [ 7 ], coronary artery disease [ 8 ], or heart failure [ 9 ]. In addition, TyG was a novel biomarker of myocardial fibrosis in HF patients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose Index Was a Predictor of 6-Month Readmission Caused by Pulmonary Infection of Heart Failure Patients

Shi

Liu

Zhu

et al. 2022

International Journal of Endocrinology

View full text Add to dashboard Cite

Objectives. Insulin resistance is associated with the prognosis of heart failure (HF) patients. The triglyceride glucose (TyG) index is a simple marker of insulin resistance. However, it remains unclear whether the TyG index is associated with the incidence of readmission in patients with HF. Methods. We enrolled 901 patients with completed records on serum triglyceride and glucose in our study. The TyG index was calculated as log (fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2). There were 310 cases of readmission and the average TyG index was 7.8 ± 0.7. Restricted cubic spline was fitted to explore the linearity of TyG index associating with 6-month readmission of HF patients. Logistic regression analysis was performed to explore the association between TyG index quartile and the incidence of 6-month readmission. Results. Only the 6-month readmission was significantly different among TyG quartiles, and it was the highest (41.9%) in the lowest quartile (ranging 6.17∼7.36). the TyG index was nonlinearly associated with 6-month readmission ( p for nonlinearity = 0.009), with the lower level of TyG index increasing the risk of 6-month readmission. Besides, multivariable logistic analysis showed that the lowest TyG quartile was associated with a higher incidence of 6-month readmission in the unadjusted model (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.18–2.57; p = 0.005 ), partially adjusted model (OR 1.82, 95%CI 1.22–2.72; p = 0.004 ), and fully-adjusted model (OR 1.65, 95%CI 1.09–2.45; p = 0.024 ). The association was consistent across gender and diabetes group. Conclusion. A lower TyG index independently increased the risk of 6-month readmission in HF patients, which could be a prognostic factor in heart failure.

show abstract

Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Cited by 30 publications

References 57 publications

Association between triglyceride-glucose index and carotid atherosclerosis detected by ultrasonography

Association between triglyceride-glucose index and carotid atherosclerosis detected by ultrasonography

The predictive value of the triglyceride—glucose index for cardiovascular events in patients with coronary chronic total occlusion

Triglyceride Glucose Index Was a Predictor of 6-Month Readmission Caused by Pulmonary Infection of Heart Failure Patients

Contact Info

Product

Resources

About