Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcoma

Abstract

This paper focuses on the voltages electromagnetically induced by the multiple return strokes involved in a triggered lightning on an overhead power line and a vertical signal line of an automatic weather station (AWS), and the backflow currents and residual voltages in a surge protection device (SPD) embedded in the power line. Pulses of voltage on the overhead power line corresponding to the return strokes with the peak currents ranging from −6.67 to −26.47 kA showed bipolar features. Subpeaks and main peaks ranged from 0.99 to 4.47 kV and from −4.98 to −10.31 kV, respectively. The voltage waveforms corresponding to the return strokes on the vertical signal line of wind speed were of two types: with and without a subpeak after the main peak. All the main peaks, with the peak value from −0.41 to −3.10 kV, were ‘V’ shaped. A significant relationship exists between the peak currents of the return strokes and the 10–90% average gradients of the voltages. The peaks of currents through the SPD ranged from −0.22 to −1.64 kA. The durations of residual voltages ranged from 0.6 to 5.9 ms, average value being 2.1 ms. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.

Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma

“…Moreover, several reports indicating an oncogenic, rather than a tumor-supressor, role of the wild-type WT1 gene have been accumulated. For example, high expression levels of WT1 messenger ribonucleic acid (mRNA) are correlated with poor prognosis in leukemias [15], breast cancer [19], and soft tissue sarcomas [33]. Treatment with WT1 antisense oligomers specifically causes growth inhibition in leukemic blast cells [2,39] and in cell lines derived from cancers of the lung, stomach, colon, and breast [24,41].…”

“…Although the WT1 gene was primarily considered to be a tumor-suppressor gene, recent studies have demonstrated an overexpression of the wild-type WT1 gene in leukemias [15] and various solid neoplasms such as those of the breast [16,19], lung, digestive tract [25,26], pancreas [23], bone, and soft tissues [33,37]. Moreover, several reports indicating an oncogenic, rather than a tumor-supressor, role of the wild-type WT1 gene have been accumulated.…”

Expression of Wilms tumor 1 gene in a variety of pediatric tumors

“…These factors may reduce the mRNA levels of the tumor specimens, which may disturb the accurate analysis between mRNA levels and clinical data. Sotobori et al [17] investigated WT1 mRNA expression in adult cases of soft tissue sarcoma. They observed the WT1 mRNA expression levels in soft tissue sarcomas to be significantly greater than the levels in normal soft tissues, and the disease-specific survival rate for patients with high WT1 mRNA expression levels was found to be significantly poorer in comparison with the rate for patients with low WT1 mRNA expression levels.…”

WT1 silencing by RNAi synergizes with chemotherapeutic agents and induces chemosensitization to doxorubicin and cisplatin in B16F10 murine melanoma cells

“…High WT1 mRNA expression levels have been correlated with a biologically aggressive phenotype that has been associated with a poor prognosis for leukemia (21) and sarcoma (22). Leukemia patients who had high levels of WT1 mRNA had increased drug resistance and worse overall survival than patients who had low levels of WT1 mRNA (21,23).…”