Prognostic value of abnormally expressed lncRNAs in ovarian carcinoma: a systematic review and meta-analysis

Abstract

Ovarian cancer (OC) is the most deadly gynecological cancer and it is urgently needed to find a new marker for the progress of OC. Many long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in ovarian carcinoma, and may serve as prognostic markers. Therefore, we conducted this meta-analysis to gain a better understanding of the prognostic value of lncRNAs in patients with varian carcinoma. We systematically searched PubMed, EMBASE, and Web of Science. A total of 13 eligible studies, including 10 on clinicopathological features, 13 on prognosis were identified. Pooled hazard ratios (HRs) or odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated using random-or fixed-effects models. Our results revealed that the increased expressions of 8 lncRNAs were associated with poor prognosis and the decreased expressions of 5 lncRNAs were related to poor prognosis in ovarian carcinoma. High HOTAIR expression was associated with shorter overall survival in ovarian cancer (pooled HR: 2.05, 95% CI: 1.51-2.77, P < 0.001).In conclusion, our meta-analysis suggested that LncRNAs could function as potential prognostic markers for ovarian cancer patients and high expression HOTAIR was associated with shorter overall survival in ovarian cancer.

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

“…All of these findings show that HOTAIR was an independent prognostic factor for predicting OS in patients with OC. A recent meta-analysis indicated that lncRNAs, including HOTAIR, could function as potential prognostic markers for patients with OC and that high HOTAIR expression was associated with shorter OS in OC [106]. Mechanistically, the results demonstrated that ectopic HOTAIR expression induced the activation of NF-κB signaling during DNA damage response (DDR) and induced the expression of the key NF-κB target gene interleukin-6 [106]; these actions indicate the critical role of HOTAIR in cellular senescence and platinum sensitivity.…”

“…A recent meta-analysis indicated that lncRNAs, including HOTAIR, could function as potential prognostic markers for patients with OC and that high HOTAIR expression was associated with shorter OS in OC [106]. Mechanistically, the results demonstrated that ectopic HOTAIR expression induced the activation of NF-κB signaling during DNA damage response (DDR) and induced the expression of the key NF-κB target gene interleukin-6 [106]; these actions indicate the critical role of HOTAIR in cellular senescence and platinum sensitivity. Thus, the NF-κB-HOTAIR regulatory axis triggered a positive-feedback loop cascade during DDR and contributed to cellular senescence as well as chemotherapy resistance in ovarian and other types of cancer [107].…”

Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

“…HOTAIR is upregulated in endometrial cancer (EC) (Smolle, et al 2015) and contributes to cisplatin-resistance by inhibiting autophagy (Sun, et al 2017b). HOTAIR is highly expressed in ovarian cancer (Luo, et al 2017), in endometrial, ovarian, and cervical cancers (Li, et al 2017a), and in thyroid cancers ), including PTC (Zhu et al 2016).…”

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

“…Interestingly, as DNA is unlikely to change, HOTAIR DNA-based prognostic biomarkers could be used as reliable classifiers to distinguish patients for personalized treatment. Moreover, a recent meta-analysis of data from 13 studies revealed 8 up-regulated and 5 down-regulated lncRNAs associated with poor prognosis, and of these lncRNAs, higher expression of HOTAIR was associated with shorter OS in patients with OC [78].…”