Prognostic value of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and multiphasic renal tomography findings in histological subtypes of renal cell carcinoma

Abstract

BackgroundTo determine the relationship between renal cell carcinoma subtypes and the associated mortality and biochemical parameters. An additional aim was to analyze multiphasic multidetector computed tomography findings.MethodsThis study is a hospital-based retrospective investigation, using 211 patients with a diagnosis of renal cell carcinoma upon computed tomography examination. The histological subtypes included clear cell in 119 patients, chromophobe cell in 30 patients, papillary cell in 25 patients, mixed cell in 32 patients, and sarcomatoid cell in 4 patients.ResultsThe mean age of the patients participating in this study was 61.18 ± 11.81 years, and the mortality rate was 10.4% (n = 22) through the 2-year follow-up. The ratios of both the neutrophil-to-lymphocyte upon admission to the hospital and platelet-to-lymphocyte of the non-surviving group were significantly higher than those of the surviving group (p < 0.05). When the analysis of the 2-year survival of the patients was examined according to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups (p = 0.01). In two-way analysis of variance test, statistically significant results which were influenced by mortality (p = 0.028) and were found between renal cell carcinoma subtypes in the computed tomography density of corticomedullary phase (p = 0.001).ConclusionsThe neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio may represent widely available biomarkers in renal cell carcinoma, and the logistic regression model indicated that neutrophil-to-lymphocyte ratio was a significant predictor for mortality. According to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups.

Increased neutrophil–lymphocyte ratio independently predicts poor survival in non‐metastatic triple‐negative breast cancer patients

“…Therefore, NLR may represent an innovative, precise, and repeatable laboratory parameter to identify TNBC patients with poorer prognosis. Our data confirmed previous reports in which NLR was shown to have prognostic value in various other cancers, such as non‐small‐cell lung, gynecological, urological, and gastrointestinal cancers, and soft‐tissue sarcoma, .…”

“…Therefore, NLR may represent an innovative, precise, and repeatable laboratory parameter to identify TNBC patients with poorer prognosis. Our data confirmed previous reports in which NLR was shown to have prognostic value in various other cancers, such as non-small-cell lung, gynecological, urological, and gastrointestinal cancers, and soft-tissue sarcoma, (9,(27)(28)(29)(30)(31)(32)(33)(34)(35). The relationships between NLR and clinicopathological features such as tumor size, lymph node involvement, angiogenesis, metastasis, and positive bio-marker expression have rarely been reported previously (36).…”

Prognostic significance of platelet–lymphocyte ratio in patients receiving first-line tyrosine kinase inhibitors for metastatic renal cell cancer

“…Therefore, inflammation markers have been regarded as significant for tumor progression and as risk factors for tumor recurrence. It has been recently suggested that systemic inflammation-based scores such as GPS (including albumin and CRP values), NLR, and PLR might be significant predictors of OS and PFS of cancer patients (de Vivar Chevez et al 2014; Feng et al 2014; Raungkaewmanee et al 2012; Hu et al 2015; Song et al 2016; Nakano et al 2014; Templeton et al 2014a, b; Keskin et al 2014). Over the last decade, it has become clear that these parameters are consistently associated with poor outcome, regardless of the tumor stage.…”

“…Moreover, the effect of high PLR on OS was greater for metastatic disease than for early stage disease (Templeton et al 2014b). However, Keskin et al (2014) showed that only preoperative high NLR was associated with mortality in renal cell carcinoma. Thus, the aim of this study was to investigate the relationship of NLR, PLR, and previously known prognostic factors with progression-free (PFS) and OS in patients with mRCC.…”

Yüksek nötrofil- lenfosit oranının renal hücreli karsinomda preoperatif ve postoperatif dönemde sağkalıma etkisi

“…Various studies have shown that high NLR is a poor prognostic factor such as in pancreatic, colorectal, lung, breast cancers (6)(7)(8)(9)). An increased neutrophillymphocyte ratio (NLR) has been proposed as a marker to predict the prognosis of RCC patients and many studies found preoperative NLR as a poor prognostic marker in RCC (10)(11)(12)(13)(14). We hypothesize that a high NLR is associated with poor prognosis even its assesed postoperative.…”