Prognostic value of serum cystatin C and N-terminal pro b-type natriuretic peptide in patients with acute heart failure

Pérez-Calvo, Juan Ignacio; Fj, Ruiz-Ruiz; Carrasco-Sánchez, Francisco Javier; Morales-Rull, J.L.; Manzano‐Fernández, Sergio; Galisteo-Almeda, Luis; Pascual-Figal, Domingo A.

doi:10.1016/j.ejim.2012.06.002

Cited by 28 publications

(11 citation statements)

References 28 publications

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“…Chronic complications of diabetes have become the leading cause of death in elderly patients with diabetes mellitus. Carotid artery thickening, one of the major complications of diabetes, is regarded as a sign of early atherosclerosis, and a ‘window’ for systemic arterial disease. In the present study, the characteristics of carotid atherosclerotic plaques in elderly patients with type 2 diabetes and the effect of atorvastatin on carotid atherosclerotic plaques in very elderly patients with type 2 diabetes were observed.…”

Section: Introductionmentioning

confidence: 47%

Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Tian

Wang

Xue

et al. 2017

J of Diabetes Invest

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IntroductionChronic complications of diabetes have become the leading cause of death in elderly patients with diabetes. Carotid atherosclerosis, one of the major complications, was evaluated and the effects of atorvastatin on carotid atherosclerosis in very elderly patients with type 2 diabetes were observed.Materials and MethodsPatients were divided into three groups: (i) disease course <5 years; (ii) disease course 5–10 years; (iii) disease course >10 years, and carotid atherosclerosis was evaluated. The very elderly patients were treated with statins, and the effect was observed.ResultsCarotid intima‐media thickness values, plaque instability and levels of homocysteine, cystatin, and C‐reactive protein in diabetes patients were significantly higher than those in the healthy control group, whereas levels of C‐peptide and estimated glomerular filtration rate in the patients were significantly lower. In patients with type 2 diabetes for >10 years, intima‐media thickness values and plaque instability were obviously higher than those in patients with type 2 diabetes for <5 years, while levels of fasting C‐peptide and estimated glomerular filtration rate were lower than those in patients with type 2 diabetes for <5 years. In the very elderly patients, after statins treatment, intima‐media thickness values, levels of homocysteine and C‐reactive protein were significantly reduced, as well as the number of unstable plaques.ConclusionsIn the elderly patients with type 2 diabetes, carotid atherosclerosis‐related factors increased obviously, and renal function declined obviously, which were closely related to the disease course. Atorvastatin significantly reduced homocysteine and C‐reactive protein, and delayed and reversed the progress of carotid atherosclerosis in very elderly patients with type 2 diabetes.

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Section: Introductionmentioning

confidence: 47%

Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Tian

Wang

Xue

et al. 2017

J of Diabetes Invest

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“…However, multiple studies have shown that CysC also predicts left heart failure and overall cardiovascular mortality . Furthermore, CysC may be superior to NT‐ProBNP in the prediction of acute left heart failure‐related mortality . In contrast with BNP and NT‐ProBNP, serum CysC levels appear to be independent of muscle mass, age and gender .…”

Section: Introductionmentioning

confidence: 98%

Cystatin C: A potential biomarker for pulmonary arterial hypertension

et al. 2014

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“…Many studies report on the prognostic value of natriuretic peptides in patients presenting with acute breathlessness, many of whom do not have heart failure . In this setting, a biomarker that identifies patients with a disease that carries a poor prognosis is likely to predict outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Such models are of limited clinical use for managing individual patients or for service redesign. Biomarkers might improve prediction but whether they add prognostic value to standard routine clinical variables for patients with AHF has seldom been reported . Accordingly, we took the opportunity to investigate the value of adding B‐type natriuretic peptide (BNP) and troponins to conventional prognostic markers in a large multicentre study of AHF.…”

Section: Introductionmentioning

confidence: 99%

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure—does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS)

Cleland

Teerlink

Davison

et al. 2017

European J of Heart Fail

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There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.Cleland, J. G. F. et al. (2017) Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? Objective: To investigate the added prognostic value of admission measurements of brain natriuretic peptides (BNP) and troponins in patients with acute heart failure.Background: Plasma concentrations of BNP and troponin are often measured for diagnostic

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Prognostic value of serum cystatin C and N-terminal pro b-type natriuretic peptide in patients with acute heart failure

Cited by 28 publications

References 28 publications

Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Cystatin C: A potential biomarker for pulmonary arterial hypertension

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure—does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS)

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