Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Tian, Tao; Wang, Shiming; Xue, Yan; Sun, Zongqin; Wang, Shuli

doi:10.1111/jdi.12710

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…Furthermore, they may become increasingly worried about the severity of DE and the effect of treatment, which may then lead to depression and anxiety. This finding was consistent with previous studies on other diseases, which show that long disease duration, severe symptoms, and impaired social function were associated with anxiety and depression (73).…”

Section: Discussionsupporting

confidence: 93%

Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor analysis

Chen

Shi

et al. 2022

Front. Public Health

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ObjectiveInvestigate the anxiety and depression states among dry eye (DE) patients during the COVID-19 outbreak and analyze their influence factors.MethodsThe study was conducted in a tertiary eye hospital in Tianjin, China from March–April 2021. Four hundred twenty-eight DE patients were tested with the Ocular Surface Disease Index, Short Healthy Anxiety Inventory, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Index. Descriptive statistics was used to assess the difference between DE with depression or anxiety among different groups. And multiple linear regression was used to explore factors that influence anxiety and depression in DE patients.ResultsThe incidence rates of anxiety and depression among DE patients during COVID-19 were 27.34 and 26.87%, respectively. The proportion with comorbid anxiety and depression was 24.30%. Patients' education level (t = −3.001, P < 0.05; t = −3.631, P < 0.05), course of disease (t = 2.341, P < 0.05; t = 2.444, P < 0.05), health anxiety (t = 3.015, P < 0.05; t = 2.731, P < 0.05), and subjective sleep quality (t = 3.610, P < 0.05; t = 4.203, P < 0.05) had certain influences on anxiety and depression.ConclusionThe results showed that subjective symptoms of DE patients were related to depression and anxiety. Higher education, shorter disease duration, lower health anxiety levels, and better subjective sleep quality were associated with the reduced depressive and anxiety symptoms in DE patients. These findings could be deemed beneficial to the treatment and prevention of DE during the COVID-19 epidemic.

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Section: Discussionsupporting

confidence: 93%

Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor analysis

Chen

Shi

et al. 2022

Front. Public Health

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“…Continuous exposure to hyperglycemia, oxidative stress and increased systemic inflammation factors might induce many changes in the vascular that might accelerate atherosclerosis 18,19 . Compared with the healthy control group, the carotid intima-media thickness values of diabetes patients were significantly higher 20 . Diabetes patients showed a greater percent atheroma volume and total atheroma volume in coronary atherosclerosis 19 .…”

Section: Discussionmentioning

confidence: 71%

“…Surprisingly, the duration of type 2 diabetes mellitus was not significantly associated with intracranial plaque enhancement or plaque burden. Compared with patients who had type 2 diabetes mellitus for <5 years, carotid plaque vulnerability and the intima-media thickness values of patients with type 2 diabetes mellitus for >10 years were obviously higher 20 . A retrospective study showed that the prevalence of peripheral arterial and coronary atherosclerosis significantly increased with the duration of type 2 diabetes mellitus 27 .…”

Section: Discussionmentioning

confidence: 78%

Association between type 2 diabetes mellitus, especially recently uncontrolled glycemia, and intracranial plaque characteristics: A high‐resolution magnetic resonance imaging study

Huang

Jiao

Song

et al. 2020

J of Diabetes Invest

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Aims/Introduction Type 2 diabetes mellitus is a specific risk factor for intracranial atherosclerosis. The purpose of this study was to investigate the relationship between type 2 diabetes mellitus, especially uncontrolled glycemia, and intracranial plaque characteristics using high‐resolution magnetic resonance imaging. Materials and Methods A total of 263 patients (182 men; mean age 62.6 ± 11.5 years) with intracranial atherosclerotic plaques detected on high‐resolution magnetic resonance imaging from December 2017 to March 2019 were included in this study. Patients were divided into different groups: (i) patients with and without type 2 diabetes mellitus; (ii) diabetes patients with uncontrolled glycemia (glycated hemoglobin level ≥7.0%) and controlled glycemia; and (iii), diabetes patients with diabetes duration of <5, 5–10 and >10 years. Comparisons of plaque features between groups were made, respectively. Results Type 2 diabetes mellitus was diagnosed in 118 patients (44.9%). Diabetes patients had a significantly greater prevalence of enhanced plaque, greater maximum plaque length, maximum wall thickness and more severe luminal stenosis than non‐diabetes patients. Compared with diabetes patients with controlled glycemia, those with uncontrolled glycemia had a significantly greater prevalence of enhanced plaque and greater maximum plaque length (all P < 0.05). There were no significant differences in plaque features among patients with different durations of type 2 diabetes mellitus. Uncontrolled glycemia was an independent factor for plaque enhancement after adjustment for potential confounding factors (odds ratio 5.690; 95% confidence interval 1.748–18.526; P = 0.004). Conclusions Type 2 diabetes mellitus is closely related to intracranial plaque enhancement and burden. Recently uncontrolled glycemia might play an important role in the development of enhanced plaque.

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“…Virtual-histology intravascular ultrasound (VH-IVUS) can evaluate plaque stability in vivo. According to the VH-IVUS classification, thin fibrous cap atherosclerosis is closely related to future cardiovascular events and is known as vulnerable plaques [ 2 ]. Changes in serum adipokine C1q/tumor necrosis factor-related protein 9 (CTRP9), amyloid A (SAA), and plasma homocysteine (Hcy) levels can be used as indicators to reflect the stability of coronary atherosclerotic plaque [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Coronary VH-IVUS Plaque Characteristics and CTRP9, SAA, and Hcy in Patients with Coronary Heart Disease

Liu¹,

Wang²,

Wang³

et al. 2022

Journal of Healthcare Engineering

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Coronary heart disease is a common disease threatening human health. In recent years, the incidence of coronary heart disease in China has only increased. It is the most common type of organ disease caused by coronary atherosclerosis, which is observed in the aorta, carotid artery, and femoral artery. The main clinical treatments for coronary heart disease include coronary artery bypass grafting and drug treatment. To investigate the relationship of serum adipocytokine C1q/tumor necrosis factor-related protein 9 (CTRP9), amyloid A (SAA), and plasma homocysteine (Hcy) with coronary artery plaque characteristics in patients with coronary heart disease. Overall, 143 patients with coronary heart disease admitted to our hospital are selected as research participants. The proportion of plaque necrosis core volume is higher in group A than in group B, and the differences are statistically significant ( P < 0.05 ). In group A, necrotic core volume percentage is negatively correlated with CTRP9 levels and positively correlated with SAA and Hcy levels ( P < 0.05 ). Logistic regression analysis revealed that increased systolic blood pressure, increased number of coronary artery lesions, decreased CTRP9 levels, and increased Hcy levels are independent risk factors for thin fibrous cap atherosclerosis in patients with coronary heart disease ( P < 0.05 ). Decreased CTRP9 levels and increased Hcy levels are independent risk factors for coronary heart disease patients with thin fibrous cap atherosclerosis.

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Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients

Cited by 9 publications

References 11 publications

Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor analysis

Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor analysis

Association between type 2 diabetes mellitus, especially recently uncontrolled glycemia, and intracranial plaque characteristics: A high‐resolution magnetic resonance imaging study

Relationship between Coronary VH-IVUS Plaque Characteristics and CTRP9, SAA, and Hcy in Patients with Coronary Heart Disease

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