Prognostic value of serum potassium level predicting the duration of recumbency in downer cows due to metabolic disorders

Beder, Noha A.; El-Kasrawy, Nagwa I.; Goda, Wael; Abdel-Latif, Mervat A.

doi:10.1007/s11250-020-02395-3

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…It is not known whether the same results would be obtained using today's reagents and biochemistry analysers, so further work may be required to check that the measurement of AST activity, CK activity and urea concentration has not changed significantly in this period. In addition, any further work on improving the performance of prognostic profiles for downer cows in New Zealand should possibly include some assessment of heart damage either using cardiac troponin (Labonte et al 2018) or heart rate > 100 beats per minute (Puerto-Parada et al 2021) and the measurement of serum potassium concentration (Beder et al 2020). All these variables have been found useful in overseas studies but have not been evaluated under New Zealand systems and conditions.…”

Section: Discussionmentioning

confidence: 99%

Downer cows: a reanalysis of an old data set

Lawrence

Clark²,

et al. 2023

New Zealand Veterinary Journal

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Aims: To compare the performance of two predictive models for the survival of downer cows. Methods: The first model had been developed in 1987 using a dataset containing missing values, while the second, new model was developed on the same dataset but using modern data imputation and analytical methods. Missing data were imputed using multiple imputation by chained equations and a logistic regression model fitted to the imputed data, with survival or not as the outcome variable. The predictive ability of the model built on the imputed data was contrasted with the original prognostic model by testing them both on a second smaller but complete data set, collected contemporaneously with the development of the original model but from a different region of New Zealand. Sensitivity, specificity, accuracy, and cut point for the two models were calculated. Results: The original 1987 model had a slightly higher accuracy than that of the new one with a sensitivity of 0.85 (95% CI = 0.72-0.94) and a specificity of 0.82 (95% CI = 0.7-0.91), using a cut point for the probability of survival = 0.313. Conclusions: The original prognostic formula published by Clark et al. in 1987 performed as well as a modern model built on an imputed data set. Clinical relevance: The use of a prognostic test based on the Clark model should remain an important part of the clinical examination of downer cows by New Zealand veterinarians.

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Section: Discussionmentioning

confidence: 99%

Downer cows: a reanalysis of an old data set

Lawrence

Clark²,

et al. 2023

New Zealand Veterinary Journal

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“…Further administration of Ca to cows after milk fever treatment shortens QTc and causes arrhythmia [18,19]. Cows with downer cow syndrome have low blood K levels, and hypokalemia prolongs the QT interval [4,17]. The QTc and QT interval are synonymous with the STc and ST interval, respectively [14].…”

Section: Discussionmentioning

confidence: 99%

Improving the accuracy of estimating blood calcium concentration in Holstein cows using electrocardiographic variables

Itoh

Nakajima

Kuwano

et al. 2022

The Journal of Veterinary Medical Science

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We previously reported the possibility of using the electrocardiogram variable to estimate blood calcium (Ca) concentration in dairy cows based on the strong positive correlation between the blood Ca concentration and the inverse of the corrected ST peak interval (STc −1 ).To improve the accuracy of the estimation of blood Ca concentration, we investigated the relationship between blood Ca concentration and STc −1 for each postpartum day and available variables other than STc −1 . We measured multiple variables (milk yield, calving number, age, body temperature, etc.), including serum total Ca concentration (tCa), blood ionized Ca concentration (iCa) and STc −1 in 462 Holstein cows on days 0, 1, 2, 3, 5, and 7 postpartum. A very high correlation was observed between iCa and tCa. The association between tCa and STc −1 for each postpartum day had a high coefficient of determination of 0.61-0.79 postpartum 0-2 days but decreased after the third day. In the investigation using the data from postpartum days 0-2, STc −1 , heart rate interval, calving number, and age were highly correlated with tCa.In addition, a multiple regression equation was obtained with tCa as the objective variable and STc −1 and calving number as explanatory variables. The estimation accuracy was improved as compared with the simple regression equation using only STc −1 as the explanatory variable. This multiple regression equation was used for 11 cows suspected of having hypocalcemia, and it was able to correctly detect cows requiring early treatment, except for one cow.

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“…The cow was treated with 225 ml of 25 per cent calcium borogluconate as slow IV, once daily for two days (Constable et al, 2017), potassium chloride @ 120 gm twice daily orally for three days (Constable et al, 2013 ;Beder et al, 2020), flunixin meglumine @ 1.1 mg/ kg body weight once daily IV, for three days (Jesse et al, 2016) and Inj. vitamin B 1 , B 6 and B 12 -15 ml daily IV, sodium acid phosphate @ 60g, orally once daily and supportive treatment by vitamin ADE, Selenium, Biotin liquid @ 10 ml orally, once daily for seven days.…”

Section: Abstract: Downer Cow Cow Sling Potassium Chloridementioning

confidence: 99%

A case study on therapeutic management of a cross-bred downer cow

Das¹,

Biju²,

Umesh³

et al. 2021

J Vet Anim Sci

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A five year old cross bred cow, 24 hours post calving was presented to Teaching Veterinary Clinical Complex (TVCC), Pookode, with the history of recumbency 24 hours post calving. The serum biochemical parameters of calcium, phosphorus and potassium on the first day of presentation were 7.93 mg/dL, 3.82 mg/dL and 3.67 mEq/L, respectively. Tentatively the condition was diagnosed as downer cow with metabolic origin. The cow was treated with calcium borogluconate, flunixine meglumine and inj. Vitamin B1, B6, B12, sodium acid phosphate, vitamin ADE, Selenium, Biotin liquid for 7 days. Along with this, potassium chloride was administered for two days. The supportive treatment was done with lifting of cow using cow sling. Sand bedding was provided along with physiotherapy of rolling of the recumbent cow alternate ways six times a day. The serum biochemical parameters became normal on 8th day and the cow recovered by 13th day.

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Prognostic value of serum potassium level predicting the duration of recumbency in downer cows due to metabolic disorders

Cited by 3 publications

References 14 publications

Downer cows: a reanalysis of an old data set

Downer cows: a reanalysis of an old data set

Improving the accuracy of estimating blood calcium concentration in Holstein cows using electrocardiographic variables

A case study on therapeutic management of a cross-bred downer cow

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