Prognostic variables in canine multicentric lymphosarcoma

Dobson, J. M.; Blackwood, Laura; McInnes, Elizabeth F.; Bostock, D. E.; Nicholls, P.K.; Hoather, T.; Tom, Brian D. M.

doi:10.1111/j.1748-5827.2001.tb02485.x

Cited by 107 publications

(119 citation statements)

References 17 publications

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“…Age-specific incidence rates calculated in the USA included 1.5∕100,000 in dogs less than one year old and more than 80∕100,000 in dogs 10 years old (Dorn et al 1967). Although no gender tendency is associated with lymphoma in dogs, males (63%) were predominant in this study, equal to a study conducted in southern Brazil (Figueira et al 2006) and similar with results from other countries where the proportion of males varied from 53% to 58% (MacEwen et al 1987, Dobson et al 2001. Dobson et al (2001) observed a mean weight of 31.6 kg (SD=14 kg) in dogs with lymphoma; in this study, the mean weight of affected animals was 19.5 kg, which reflects the occurrence of lymphoma in both small and large breeds.…”

Section: Resultssupporting

confidence: 77%

“…Although no gender tendency is associated with lymphoma in dogs, males (63%) were predominant in this study, equal to a study conducted in southern Brazil (Figueira et al 2006) and similar with results from other countries where the proportion of males varied from 53% to 58% (MacEwen et al 1987, Dobson et al 2001. Dobson et al (2001) observed a mean weight of 31.6 kg (SD=14 kg) in dogs with lymphoma; in this study, the mean weight of affected animals was 19.5 kg, which reflects the occurrence of lymphoma in both small and large breeds. Some small breeds that frequently experience lymphoma include the Poodle and Scottish Terrier (MacEwen et al 1987, Dobson et al 2001, which were represented in this study.…”

Section: Resultssupporting

confidence: 77%

“…Dobson et al (2001) observed a mean weight of 31.6 kg (SD=14 kg) in dogs with lymphoma; in this study, the mean weight of affected animals was 19.5 kg, which reflects the occurrence of lymphoma in both small and large breeds. Some small breeds that frequently experience lymphoma include the Poodle and Scottish Terrier (MacEwen et al 1987, Dobson et al 2001, which were represented in this study. However, excluding the mixed breed animals, 59% of the dogs in this study were large breed, including the most frequently diagnosed Boxer, Rottweiler and German Shepherd (Dobson et al 2001, Pastor et al 2009).…”

Section: Resultsmentioning

confidence: 93%

“…It is known that lymphomas affect dogs of all ages, predominantly those of middle age (Teske 1994). Studies have documented mean ages ranging from 6.2 to 8.9 years in dogs with lymphoma (Dorn et al 1967, Sequeira et al 1999, Dobson et al 2001). Age-specific incidence rates calculated in the USA included 1.5∕100,000 in dogs less than one year old and more than 80∕100,000 in dogs 10 years old (Dorn et al 1967).…”

Section: Resultsmentioning

confidence: 99%

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Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil

Neuwald

Teixeira

Conrado³

et al. 2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(4):349-354, abril 2014 349 RESUMO.-[Aspectos epidemiológicos, clínicos e imuno-histoquímicos do linfoma canino na região de Porto Alegre.] Esse trabalho apresenta os achados epidemioló-gicos, clínicos e imuno-histoquímicos de linfomas caninos diagnosticados na região de Porto Alegre. Trinta cães foram incluídos no estudo; sendo principalmente machos (60%), sem raça definida (23%) e de meia-idade a idosos. A maioria (87%) dos cães afetados apresentou a forma anatômica multicêntrica. O imunofenótipo B foi detectado com mais frequência (62%); 37% dos cães apresentavam estadiamento clínico IV e 83% encontravam-se no subestádio "b". Linfadenopatia foi observada em 67% dos casos; outros sinais clínicos comumente detectados foram dispneia, prostração, diminuição do apetite e vômitos. Anemia foi a alteração laboratorial mais frequente (57%), seguida por leucocitose (40%), trombocitopenia (33%), linfopenia (30%), hiperglobulinemia (20%), hiperproteinemia (17%) e hipercalcemia (13%). Os resultados do presente estudo indicam que as características epidemiológicas e clínicas de cães com linfoma na região de Porto Alegre são semelhantes às observadas em todo o mundo.TERMOS DE INDEXAÇÃO: Linfoma, síndromes paraneoplásicas, sinais clínicos, imuno-histoquímica, caninos. INTRODUCTIONLymphoma is the most common canine hematopoietic neoplasm, with reported incidences of 24 to 33 cases per 100,000 dogs (Dorn et al. 1967, Teske 1994. In Brazil, lymphoma is the second most common canine neoplasm leading to death or euthanasia (Fighera et al. 2008 This paper describes the epidemiological, clinical and immunohistochemical characteristics of canine lymphomas diagnosed in the region of Porto Alegre, Brazil. Thirty dogs were enrolled in the study; most of them were male (60%), mixed-breed (23%) and middle-aged or older. The majority (87%) of affected dogs showed the multicentric form. The B-cell phenotype was most frequently detected (62%); 37% of the animals were in clinical stage IV, and 83% were classified as sub-stage "b". Lymphadenopathy was observed in 67% of the cases, and dyspnea, prostration, decreased appetite and vomiting were the most common clinical signs encountered. Anemia was a frequently encountered laboratory alteration (57%), as were leukocytosis (40%), thrombocytopenia (33%), lymphopenia (30%), hyperglobulinemia (20%) and hypercalcemia (13%). The results of this study indicate that the clinical features of dogs with lymphoma in the region of Porto Alegre are similar to those observed worldwide.

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Section: Resultssupporting

confidence: 77%

Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil

Neuwald

Teixeira

Conrado³

et al. 2014

Pesq. Vet. Bras.

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“…7 In such cases, PARR may be an effective method for the differential diagnosis of alimentary lymphoma. Because T-cell lymphoma has a short survival time compared with B-cell lymphoma, 3 phenotypic classification of lymphoma is essential to the prognosis. For example, when dogs with histologically diagnosed enteritis showed TCRc clonality, their survival time was significantly less than that of dogs negative for TCRc, which means that PARR could overcome the limitation of a histological diagnosis.…”

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confidence: 99%

Heteroduplex Polymerase Chain Reaction is Essential for Canine Receptor Rearrangement Analysis

Takanosu

Tadika

Kobayashi³

2010

J VET Diagn Invest

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Abstract. Polymerase chain reaction (PCR) for antigen receptor rearrangement is a sensitive technique for detecting lymphocyte-proliferative disorders, but it tends to produce false-positive results, a phenomenon termed pseudoclonality. Heteroduplex analysis, which is useful to distinguish clonal reactions from pseudoclonal ones in dogs, can be applied to avoid misdiagnosis and determine the reliability of results. In the current study, PCR for antigen receptor rearrangement was used to identify clonal proliferation of lymphocytes in duodenal and lymphoid tissue from dogs presenting with chronic vomiting and enlarged peripheral lymph nodes typical of multicentric lymphoma, and the test results were verified with heteroduplex analysis. In the case of almost all of the duodenal samples, even without a histologic diagnosis of lymphoma, a distinct band similar to that observed in the case of lymphoma was obtained for both B-and T-cell clonality. All of the bands obtained from the nonneoplastic duodenum disappeared following heteroduplex analysis of the PCR product, whereas the distinct bands from the lymphoma remained. In the lymph node samples, the pseudoclonal bands that disappeared in the heteroduplex analysis were detected mainly in B cells. In conclusion, heteroduplex analysis with PCR for antigen receptor rearrangement is a suitable tool for diagnosing canine lymphoma and decreasing the possibility of misdiagnosis of pseudoclonality.

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B‐Cell Neoplasms

Valli¹

2007

Veterinary Comparative Hematopathology

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Prognostic variables in canine multicentric lymphosarcoma

Cited by 107 publications

References 17 publications

Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil

Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil

Heteroduplex Polymerase Chain Reaction is Essential for Canine Receptor Rearrangement Analysis

B‐Cell Neoplasms

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