2022
DOI: 10.1002/cjoc.202200155
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Programmable Analytical Feature of Ratiometric Electrochemical Biosensor by Alternating the Binding Site of Ferrocene to DNA Duplex for the Detection of Aflatoxin B1

Abstract: Comprehensive Summary Ratiometric biosensor is among the promising strategies for the advanced analysis; its applicability in multiple scenarios, however, is seriously limited for the fixed analytical feature. Here, we reported ratiometric electrochemical biosensors with programmable analytical feature by alternating the binding site of ferrocene (Fc) to DNA duplex for the detection of aflatoxin B1 (AFB1). DNA duplex was synthesized with AFB1 aptamer and its complementary DNA (cDNA) with Fc molecular tagged on… Show more

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Cited by 5 publications
(2 citation statements)
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“…Aptamers are increasingly investigated as diagnostic and therapeutic tools by virtue of their ability to recognize a wide range of molecular targets, including small molecules [ 27‐28 ] and proteins, [ 29‐31 ] with high specificity and affinity. In particular, aptamers have offered fascinating opportunities for the recognition, monitoring, and regulation of proteins in complex biological systems.…”
Section: Background and Originality Contentmentioning
confidence: 99%
“…Aptamers are increasingly investigated as diagnostic and therapeutic tools by virtue of their ability to recognize a wide range of molecular targets, including small molecules [ 27‐28 ] and proteins, [ 29‐31 ] with high specificity and affinity. In particular, aptamers have offered fascinating opportunities for the recognition, monitoring, and regulation of proteins in complex biological systems.…”
Section: Background and Originality Contentmentioning
confidence: 99%
“…At present, the commonly used physical and chemical analysis methods for the detection of aflatoxin at home and abroad include Thin Layer Chromatography (TLC), 7 High Performance Liquid Chromatography (HPLC), 8 enzyme-linked immunosorbent assay (Elisa), 9 electrochemical method 10 and so on. Although these physical and chemical analysis methods have high sensitivity for the detection of aflatoxin, they have some disadvantages, such as high detection cost, long detection period, poor experimental repeatability, complicated and tedious experimental procedures and damage to experimental samples.…”
Section: Introductionmentioning
confidence: 99%