Programmable carbon nanotube membrane-based transdermal nicotine delivery with microdialysis validation assay

Gulati, Gaurav Kumar; Chen, Tao; Hinds, Bruce J.

doi:10.1016/j.nano.2016.06.017

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…The hypothesis was that by having high charge density on GO surfaces and GO nanochannels’ entrances, water would be favored over the less polar and more sterically hindered solvents like IPA. Concentrated sulfuric acid, 4-sulfo benzene diazonium, and direct blue 71 (coupled with 4-carboxyl benzene diazonium) were grafted onto the GO surface by the method used in prior work with CNT membrane [ 46 ]. Among the chemical modification tested, 4-sulfo benzene diazonium most significantly promoted osmotic flux of water (to 0.90 LHM from 0.27 LMH of pristine GO membrane), possibly due to stronger ion rejection.…”

Section: Resultsmentioning

confidence: 99%

“…Chemical modification: Surface modifications were made to the GO membrane to accelerate the permeation of water. Chemical treatments of GO membranes were performed in a u-tube setup ( Figure 1 B) adapted from a previous study [ 46 ], except the treatment with concentrated sulfuric acid. After the GO membrane was secured between tubes, DI water was filled into the long u-tube as feed solution, while the chemical solution (0.076 mM, mmol/L, for the two diazonium chemistries as described below) was filled into the other tube (draw tube).…”

Section: Methodsmentioning

confidence: 99%

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Catalytic Reduction of Graphene Oxide Membranes and Water Selective Channel Formation in Water–Alcohol Separations

et al. 2021

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Graphene oxide (GO) is a promising membrane system for chemical separation applications due to its 2-D nanofluidics properties and an ability to control interplanar spacing for selectivity. The permeance of water, methanol (MeOH) and isopropyl alcohol (IPA) through 5 µm thick membranes was found to be 0.38 ± 0.15, 0.33 ± 0.16 and 0.42 ± 0.31 LMH/bar (liter/m2·h·bar), respectively. Interestingly, the permeance of a water–alcohol mixture was found to be dramatically lower (~0.01 LMH/bar) than any of its components. Upon removing the solvent mixture, the transmembrane flux of the pure solvent was recovered to near the original permeance. The interlayer space of a dried GO membrane was found to be 8.52 Å, which increased to 12.19 Å. 13.26 Å and 16.20 Å upon addition of water, MeOH and IPA. A decrease in d-space, about 2 Å, was consistently observed when adding alcohol to water wetted GO membrane and an optical color change and reduction in permeance. A newly proposed mechanism of a partial reduction of GO through a catalytic reaction with the water–alcohol mixture is consistent with experimental observations.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Catalytic Reduction of Graphene Oxide Membranes and Water Selective Channel Formation in Water–Alcohol Separations

et al. 2021

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“…Recent literature reports have also verified the application of indomethacin, doxorubin, and clonidine for transdermal delivery of drugs (Schwengber et al, 2015;Degim et al, 2010). Nanotube membranes have recently gained immense popularity in transdermal delivery of nicotine for cessation of smoking and opioid withdrawal symptoms (Strasinger et al, 2009;Gulati et al, 2016).…”

Section: Transdermal Drug Delivery Applicationmentioning

confidence: 93%

Emergence in the functionalized carbon nanotubes as smart nanocarriers for drug delivery applications

Beg

Rahman

Jain

et al. 2018

Fullerens, Graphenes and Nanotubes

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“…A controllable CNT membrane device has been created for the transdermal delivery of nicotine in guinea pigs [ 173 , 174 ]. This CNT membrane device had successfully delivered nicotine fluxes when switched ON and OFF, respectively, according to an in vitro flow-cell test; meanwhile, nicotine flux has been detected through in vivo microdialysis with a membrane implanted in the guinea pig’s skin.…”

Section: Carbon Nanotubes Cntsmentioning

confidence: 99%

Recent Development of Nanomaterials for Transdermal Drug Delivery

et al. 2023

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Nano-engineered medical products first appeared in the last decade. The current research in this area focuses on developing safe drugs with minimal adverse effects associated with the pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective drug toxicities. Nanomaterials provide alternatives to conventional transdermal drug delivery including patches, gels, sprays, and lotions, but it is crucial to understand the transport mechanisms involved. This article reviews the recent research trends in transdermal drug delivery and emphasizes the mechanisms and nano-formulations currently in vogue.

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Programmable carbon nanotube membrane-based transdermal nicotine delivery with microdialysis validation assay

Cited by 15 publications

References 36 publications

Catalytic Reduction of Graphene Oxide Membranes and Water Selective Channel Formation in Water–Alcohol Separations

Catalytic Reduction of Graphene Oxide Membranes and Water Selective Channel Formation in Water–Alcohol Separations

Emergence in the functionalized carbon nanotubes as smart nanocarriers for drug delivery applications

Recent Development of Nanomaterials for Transdermal Drug Delivery

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