2023
DOI: 10.1007/s11426-022-1471-2
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Progress in organocatalytic asymmetric (4+3) cycloadditions for the enantioselective construction of seven-membered rings

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Cited by 71 publications
(19 citation statements)
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“…1 Consequently, synthetic chemist continuously included their research for the construction of valuable heterocyclic molecules and hence they frequently published different methodologies in a single window. [2][3][4][5] Most of the heterocyclic scaffolds are generally achieved by either follow of old-age methodologies or using chronic and toxicological properties of chemicals. In this connection, the top most-selling medicines are pantoprazole (Protonix), lansoprazole, and omeprazole containing the pyridine ring, which was synthesized by the outmoded Hantzsch method.…”
Section: Introductionmentioning
confidence: 99%
“…1 Consequently, synthetic chemist continuously included their research for the construction of valuable heterocyclic molecules and hence they frequently published different methodologies in a single window. [2][3][4][5] Most of the heterocyclic scaffolds are generally achieved by either follow of old-age methodologies or using chronic and toxicological properties of chemicals. In this connection, the top most-selling medicines are pantoprazole (Protonix), lansoprazole, and omeprazole containing the pyridine ring, which was synthesized by the outmoded Hantzsch method.…”
Section: Introductionmentioning
confidence: 99%
“…18 d On the other hand, the MBH reaction has very seldom been used in a one-step, two-component synthesis of indolizines in a purely organocatalyzed process. 19 Batra and co-workers 18 f reported that without previous conversion to a bromide, the MBH adducts of cycloenones with N -substituted 1-formyl-β-carbolines cyclized very slowly (4 days in 1 : 1 THF–H 2 O at rt) to the corresponding indolizino-indole derivatives. A single example was reported, with an isolated yield of 58%.…”
Section: Introductionmentioning
confidence: 99%
“…In this context, we envisioned that diversifying functionalized molecules by taking advantage of known reaction pathways or exploring new reactivities of vinyl- sulfonium salts should have enormous development potential and space due to their outstanding reactivity. Under the impetus of substantial advancements in annulation reactions, 11 and as a continuation of our effort in the exploitation of novel reactions for the construction of heterocyclic compounds, 12 we first report the sequential (4 + 2) annulation/N,Selimination reaction of α-aryl vinylsulfonium salts with oxindole-derived benzylidenehydrazones, providing efficient access to structurally diverse 1,2-dihydroquinolines. Moreover, two tandem (4 + 2)/(1 + 2) annulation reactions involving α-aryl vinylsulfonium salts also were explored, leading to the generation of spiro-cyclopropane-oxindole-fused tetrahydroquinolines and epoxypropane-fused tetrahydroquinolines.…”
Section: Introductionmentioning
confidence: 99%