Progressive Resistance Exercise and Parkinson's Disease: A Review of Potential Mechanisms

David, Fabian J.; Rafferty, Miriam; Robichaud, Julie A.; Prodoehl, Janey; Kohrt, Wendy M.; Vaillancourt, David E.; Corcos, Daniel M.

doi:10.1155/2012/124527

Cited by 67 publications

(78 citation statements)

References 100 publications

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“…This disorder leads to impairments in the recruitment of motor units, and contributes to bradykinesia and muscle weakness. RT has been proposed as an effective intervention aimed at reducing muscle weakness, bradykinesia and balance problems . Several studies have shown the efficacy of strength training in improving lower limb strength, gait and balance in PD patients…”

Section: Discussionmentioning

confidence: 99%

Low‐volume resistance training improves the functional capacity of older individuals with Parkinson's disease

Leal

Abrahin

Rodrigues

et al. 2019

Geriatrics Gerontology Int

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Aim To evaluate the effects of low‐volume resistance training on the physical and functional capacity of older patients with Parkinson's disease. Methods A total of 54 patients (aged ≥60 years) were randomly divided into two groups: (i) a control group comprising 13 men and 14 women; and (ii) a resistance training group with 14 men and 13 women. The resistance training group, in addition to maintaining their pharmacological treatments, carried out 6 months of resistance training twice a week, whereas the control group maintained their pharmacological treatments. Handgrip strength, flexibility, aerobic endurance, gait speed and balance were assessed in both groups. Results After 6 months, patient functionality in the control group was reduced, whereas patients who carried out low training volumes showed significantly improved flexibility (Pre × Post: P = 0.008), aerobic resistance (Pre × Post: P = 0.006), gait speed (Pre × Post: P = 0.006) and balance (Pre × Post: P = 0.043). Significant improvement (P = 0.042) was also observed in right handgrip strength in the resistance training group. Conclusions The results of the present study showed that low‐volume resistance training improves the physical capacity of older people with Parkinson's disease. Therefore, we suggest that resistance training be a central component in exercise programs for patients with Parkinson's disease. Geriatr Gerontol Int 2019; 19: 635–640.

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Section: Discussionmentioning

confidence: 99%

Low‐volume resistance training improves the functional capacity of older individuals with Parkinson's disease

Leal

Abrahin

Rodrigues

et al. 2019

Geriatrics Gerontology Int

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“…19,125 Future research should more closely examine the effects of resistance training on non-motor symptoms in PD, especially cognition, which may relate to reduced levels of homocysteine and/or increased levels of insulin-like growth factor I. 206 At the same time, resistance training may facilitate motor improvements via increased neural drive and central neural changes, such as cross-education and reduced agonist-antagonist coactivation. 207 These mechanisms may be relevant for PD given the reduced muscle activation observed in the disorder, which largely contributes to bradykinesia and muscle weakness.…”

Section: Potential Mechanisms Of Action Of Exercise On Mood Cognitiomentioning

confidence: 99%

“…207 These mechanisms may be relevant for PD given the reduced muscle activation observed in the disorder, which largely contributes to bradykinesia and muscle weakness. 206 Drawing from functional neuroimaging studies, resistance training may also promote functional neuroplasticity in the cortex and basal ganglia, although all of these potential mechanisms require further study in PD. 206 For a review of potential mechanisms of resistance exercise in PD, please see 206 .…”

Section: Potential Mechanisms Of Action Of Exercise On Mood Cognitiomentioning

confidence: 99%

The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease

et al. 2015

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In addition to the classic motor symptoms, Parkinson’s disease (PD) is associated with a variety of non-motor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence-based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of non-motor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include non-motor outcomes in exercise trials with the goal of developing evidence-based exercise interventions as a safe, broad-spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.

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“…Dopaminergic loss in subjects with Parkinson's Disease (PD) results in reduction in corticospinal activaction with deficit in the recruitment of motor units, contributing to muscle weakness and bradykinesia 1 . Moreover, tissue changes such as the selective loss of type II muscle fibers in subjects with PD can contribute to the inability to generate strength during the performance of fast movements 2 .…”

Section: Introductionmentioning

confidence: 99%

Recruitment rate, feasibility and safety of power training in individuals with Parkinson's disease: a proof-of-concept study

Lima

Rodrigues-de-Paula

2013

Braz. J. Phys. Ther.

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| Background: It has been suggested that power training should be implemented in interventions in Parkinson's disease (PD). However, it is necessary to determine the feasibility and safety of training rapid movements in such individuals. Objectives: To determine the rate of recruitment of potential participants, the rate of attendance at training sessions, the levels of adherence to the intervention, and the rate of adverse events. Method: Patients with PD, users of the national public health system underwent power training of the lower limb muscles three times a week for 10 weeks. The number of people who were screened and recruited was recorded, as well as the rate of attendance at the training sessions and adherence to the intervention protocol. Safety was assessed by the presence of adverse events, pain, number of falls, and risk of injury associated with the intervention. Results: Over the course of eight months, 62 individuals were screened and only 13 completed the program. The rates of attendance and adherence were 88% and 97%, respectively. There were no adverse events during training. Two participants reported joint pain and one reported falls during the training period. Conclusions: The recruitment rate was low due to the subjects' difficulties with transportation and lack of interest. The high rates of adherence and attendance and the absence of adverse events suggest that power training is feasible and safe in PD.

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Progressive Resistance Exercise and Parkinson's Disease: A Review of Potential Mechanisms

Cited by 67 publications

References 100 publications

Low‐volume resistance training improves the functional capacity of older individuals with Parkinson's disease

Low‐volume resistance training improves the functional capacity of older individuals with Parkinson's disease

The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease

Recruitment rate, feasibility and safety of power training in individuals with Parkinson's disease: a proof-of-concept study

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