Prolactin Levels and Maternal Behavior Induced by Ultrasonic Vocalizations of the Rat Pup.

Hashimoto, Haruo; Saitô, Tôru; Furudate, Sen-ichi; Takahashi, Kazuaki W.

doi:10.1538/expanim.50.307

Cited by 58 publications

(43 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of particular interest is prolactin, a peptide prohormone produced in the anterior pituitary (as well as other tissues) associated with, among other things, milk production in the mammary glands. In the context of the present paper, it has been shown that exposure to rat pup ultrasounds causes a dramatic increase in prolactin, as well as maternal behaviors in lactating mother rats [35]. Several papers by Bridges and colleagues have established that centrally administered prolactin (and related placental lactogenic peptides) stimulates maternal behavior in steroid-primed female rats [11,12,13,66].…”

Section: Relationships Between Infant Crying and Parental Hormonesmentioning

confidence: 59%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

182

132

View full text Add to dashboard Cite

Crying is a universal vocalization in human infants, as well as in the infants of other mammals. Little is known about the neural structures underlying cry production, or the circuitry that mediates a caregiver's response to cry sounds. In this review, the specific structures known or suspected to be involved in this circuit are identified, along with neurochemical systems and hormones for which evidence suggests a role in responding to infants and infant cries. In addition, evidence that crying elicits parental responses in different mammals is presented. An argument is made for including 'crying' as a functional category in the vocal repertoire of all mammalian infants (and the adults of some species). The prevailing neural model for crying production considers forebrain structures to be dispensable. However, evidence for the anterior cingulate gyrus in cry production, and this structure along with the amygdala and some other forebrain areas in responding to cries is presented.

show abstract

Section: Relationships Between Infant Crying and Parental Hormonesmentioning

confidence: 59%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

182

132

View full text Add to dashboard Cite

show abstract

“…This distress behaviour is intended to elicit maternal attention and retrieval, as well as to modulate maternal care behaviour by stimulating prolactin production (Noirot, 1972;Hashimoto et al, 2001;Farrell and Alberts, 2002). These distress behaviours can be recorded and analysed both quantitatively and qualitatively in order to measure levels of distress-like behaviour in both infant mice and rats (Groenink et al, 2008;Scattoni et al, 2009).…”

Section: Separation-induced Ultrasonic Vocalizationsmentioning

confidence: 99%

The age of anxiety: role of animal models of anxiolytic action in drug discovery

Cryan¹,

Sweeney²

2011

British J Pharmacology

241

188

View full text Add to dashboard Cite

Anxiety disorders are common, serious and a growing health problem worldwide. However, the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most psychiatric disorders, remain relatively poorly understood. Animal models are an important aid in giving insight into the aetiology, neurobiology and, ultimately, the therapy of human anxiety disorders. The approach, however, is challenged with a number of complexities. In particular, the heterogeneous nature of anxiety disorders in humans coupled with the associated multifaceted and descriptive diagnostic criteria, creates challenges in both animal modelling and in clinical research. In this paper, we describe some of the more widely used approaches for assessing the anxiolytic activity of known and potential therapeutic agents. These include ethological, conflict-based, hyponeophagia, vocalization-based, physiological and cognitive-based paradigms. Developments in the characterization of translational models are also summarized, as are the challenges facing researchers in their drug discovery efforts in developing new anxiolytic drugs, not least the ever-shifting clinical conceptualization of anxiety disorders. In conclusion, to date, although animal models of anxiety have relatively good validity, anxiolytic drugs with novel mechanisms have been slow to emerge. It is clear that a better alignment of the interactions between basic and clinical scientists is needed if this is to change.

show abstract

“…It was reported that rodent pups emit USVs in situations of separation from the nest and low temperature [1], and the USVs were demonstrated to induce maternal retrieval in rats [1,2,10], mice [22] and hamsters [20]. Further, anogenital-licking behavior also was induced by USVs in rats [5].…”

Section: Introductionmentioning

confidence: 99%

“…Further, anogenital-licking behavior also was induced by USVs in rats [5]. In addition, it was shown that the USVs emitted by pups increased prolactin secretion in the mother, and maternal retrieval was induced by the increased prolactin secretion in mice and rats [4,10,21]. Thus, USVs are considered essential for communication between rodent pups and dam, and for reproduction.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Ultrasonic Vocalizations Emitted bv Rodent Pups

et al. 2004

Self Cite

View full text Add to dashboard Cite

Ultrasonic vocalizations (USVs) emitted by rodent pups, mouse, rat, Syrian hamster, vole, and Mongolian gerbil, were compared as a basic study for a screening test of anti-panic drugs. USVs of rodent pups, separated from their mother under a low temperature condition, were collected by Real-Time Spectrogram (RTS) apparatus, and transformed into spectrograms and power spectra by SIGNAL software. Waveforms of USVs emitted by the rodent pups showed several characteristic features, and species specificity of USVs was shown. We think that the species specificity might be due to differences of the anatomical structures in the respiratory tract and respiratory patterns in rodent pups.

show abstract

Prolactin Levels and Maternal Behavior Induced by Ultrasonic Vocalizations of the Rat Pup.

Cited by 58 publications

References 15 publications

Neural circuits underlying crying and cry responding in mammals

Neural circuits underlying crying and cry responding in mammals

The age of anxiety: role of animal models of anxiolytic action in drug discovery

Comparison of Ultrasonic Vocalizations Emitted bv Rodent Pups

Contact Info

Product

Resources

About