Proliferation and invasion factors in HIV-associated dysplastic and nondysplastic oral warts and in oral squamous cell carcinoma: An immunohistochemical and RT-PCR evaluation

Regezi, Joseph A.; Dekker, Nusi P.; Ramos, Daniel M.; Li, Xiaowu; Macabeo-Ong, Maricris; Jordan, Richard C.

doi:10.1067/moe.2002.129760

Cited by 14 publications

(4 citation statements)

References 20 publications

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“…Ulceration is observed in advanced human SCCs [35] and SCC in human patients usually presents as an indurated, non-healing ulcer [36]. Furthermore, infiltration by lymphocytes has been described in numerous human tumours, the presence of such cell often being associated with an improved prognosis [37-39] that these observations are in agreement with our study.…”

Section: Case Presentationsupporting

confidence: 91%

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

et al. 2014

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BackgroundSquamous cell carcinomas (SCCs) are uncommon, high-grade tumors, predominantly composed of round cells in the prepuce. The aim of this study is to better define the clinicopathologic features of this neoplasm.Case reportWe conducted cyto-histopathologic analysis on the manifestations of the prepuce SCC by H & E staining in a terrier mix dog. Grossly, tumor was large, multiple erythematous patch, and ulcerated masses frequently affecting the prepuce and deeply invading to distal prepuce out from the ventro-lateral of penis and the tumor covered by a necrotic discharge. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the prepuce comprised of round nuclei, coarse chromatin pattern, distinct nucleoli and nuclear pleomorphism. Furthermore, the neoplastic cells were pleomorphic, round to caudate in shape, exhibiting prominent anisokaryosis and anisocytosis with rare mitotic features. Microscopically, the lesions were predominantly composed of atypical round cells disposed in interlacing fascicles. Frequent findings include keratin formation, horn pearls, mitoses and cellular atypia. The cells showed distinct borders, ranged from polygonal to round or elongate and had moderate amounts of eosinophilic cytoplasm.ConclusionThe histopathologic features coupled with the cytopathology findings led to a diagnosis of squamous cell carcinoma. To the authors’ knowledge, this is the first time that multiple erythematous plaques have undergone malignant transformation in a terrier mix dog.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5748771971272873

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Section: Case Presentationsupporting

confidence: 91%

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

et al. 2014

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“…interferon-related processes). Of concern, HPV-related lesions in HIV disease may be associated with moderate or severe oral epithelial dysplasia, and similar to OSCC, dysplastic oral warts in HIV disease may have an over expression of Ki-67 (200)(201)(202). Nevertheless, there have been a small number of reports of OSCC in HIV disease (202)(203)(204)(205)(206)(207)(208), although HPV type 16 (and 51) has been demonstrated within severe oral epithelial dysplasia (209).…”

Section: Human Papilloma Virus (Hpv)mentioning

confidence: 99%

Current trends of HIV disease of the mouth

Frezzini

Leão

Porter

2005

J Oral Pathology Medicine

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HIV infection affects residents of all countries of the world, but the greater majority of affected individuals reside in the developing world. In the past decade there have been substantial changes in the management of HIV disease, particularly the introduction of highly active antiretroviral therapy (HAART). Such agents have reduced significantly the morbidity and mortality associated with HIV disease, however, they are not available for most HIV-infected individuals in the developing world. There is now considerable understanding of the molecular epidemiology, transmission and therapy of the common opportunistic oral infections of HIV disease, and as a consequence of improved anti-HIV strategies, the frequency and severity of oral disease associated with HIV infection have reduced considerably, although HAART may predispose to human papilloma virus infection of the mouth and potentially increase the risk of later oral squamous cell carcinoma. Despite advances in clinical care the majority of individuals with HIV disease worldwide will continue to develop oral disease, as they are resident in the developing world and do not have ready access to even simple therapies.

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“…Oncogenic human papillomavirus (HPV) genotypes associated with the pathogenesis of oropharyngeal cancer and nononcogenic genotypes associated with development of oral warts are both found in the oral cavity [ 1 ]. Studies report up to 56% of HIV-infected adults have detectable oral HPV DNA, a proportion substantially higher than reported in non-HIV-infected populations [ 2 – 5 ], and that oral HPV DNA and oncogenic HPV genotypes are more prevalent and have a higher incidence among HIV-positive than HIV-negative MSM [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy

Shiboski

Lee

Chen

et al. 2016

Aids

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Objective:The incidence of human papillomavirus (HPV)-related oral malignancies is increasing among HIV-infected populations, and the prevalence of oral warts has reportedly increased among HIV patients receiving antiretroviral therapy (ART). We explored whether ART initiation among treatment-naive HIV-positive adults is followed by a change in oral HPV infection or the occurrence of oral warts.Design:Prospective, observational study.Methods:HIV-1 infected, ART-naive adults initiating ART in a clinical trial were enrolled. End points included detection of HPV DNA in throat-washes, changes in CD4+ T-cell count and HIV RNA, and oral wart diagnosis.Results:Among 388 participants, 18% had at least one HPV genotype present before initiating ART, and 24% had at least one genotype present after 12–24 weeks of ART. Among those with undetectable oral HPV DNA before ART, median change in CD4+ count from study entry to 4 weeks after ART initiation was larger for those with detectable HPV DNA during follow-up than those without (P = 0.003). Both prevalence and incidence of oral warts were low (3% of participants having oral warts at study entry; 2.5% acquiring oral warts during 48 weeks of follow-up).Conclusion:These results suggest: effective immune control of HPV in the oral cavity of HIV-infected patients is not reconstituted by 24 weeks of ART; whereas ART initiation was not followed by an increase in oral warts, we observed an increase in oral HPV DNA detection after 12–24 weeks. The prevalence of HPV-associated oral malignancies may continue to increase in the modern ART era.

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Proliferation and invasion factors in HIV-associated dysplastic and nondysplastic oral warts and in oral squamous cell carcinoma: An immunohistochemical and RT-PCR evaluation

Cited by 14 publications

References 20 publications

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

Current trends of HIV disease of the mouth

Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy

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