Proliferative and Steroidogenic Effects of Follicle-Stimulating Hormone during Chick Embryo Gonadal Development

Pedernera, E.; Solís, Leonor; Peralta, Idanely Mora; Velázquez, P.N.

doi:10.1006/gcen.1999.7352

Cited by 29 publications

(9 citation statements)

References 18 publications

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“…Furthermore, because the level of Bad, another proapoptotic member of the Bcl-2 family, was slightly decreased, we further tested the level of phosphorylated Bad (the active form) and found that it was more markedly decreased at high-dose roscovitine in both canine and human cell lines (fig. 5); this finding is consistent with prior studies showing that several kinases, including Akt, phosphorylate Bad and promote survival [26, 27]. Thus, our studies indicated that low doses of roscovitine likely induce minor repairable damage to cells, which in turn cause activation of ATM, p53, and p21, and activate the Akt pathway, which prevents cells from entering the apoptosis pathway rather than the survival pathway.…”

Section: Discussionsupporting

confidence: 81%

Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease

Park¹,

Park²,

Weiss³

2008

Am J Nephrol

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Background/Aims: Control of apoptosis in autosomal dominant polycystic kidney disease (ADPKD) and in at least some cancers is likely regulated by the endogenous cyclin kinase inhibitor p21, levels of this protein being decreased in ADPKD and increased in many malignancies. The cyclin kinase inhibitor roscovitine has shown efficacy in treatment of murine PKD. We asked how a single agent can be efficacious in both PKD and cancer. Methods: Renal tubular epithelial cells were incubated at diverse roscovitine concentrations; apoptosis and senescence were measured. Subsequently, levels of pro- and antiapoptotic proteins were evaluated. Results: Renal tubular epithelial cells exposed to ‘low’ concentrations of roscovitine showed minimal apoptosis in association with markedly increased levels of the antiapoptotic protein p21, and these cells became senescent. Conversely, cells exposed to ‘high’ levels of roscovitine became apoptotic. The mechanism of antiapoptosis and senescence with ‘low’-dose roscovitine involves augmentation of the antiapoptotic proteins. Conclusions: Data in this study provide a mechanistic explanation of how roscovitine is effective in PKD, and suggest that further study of this agent should focus on assessment of dose response. Furthermore, our discovery of senescence induced by a PKD effective drug suggests a new area of therapeutic investigation in this disease.

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Section: Discussionsupporting

confidence: 81%

Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease

Park¹,

Park²,

Weiss³

2008

Am J Nephrol

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“…Owing to the effects of gonadtropins on cell proliferation in the gonads of chickens during embryogenesis (Pedernera et al ., 1999;Méndez-Herrera et al ., 1998), it is important to clarify the temporal properties of differentiation of gonadotropes during chicken pituitary gland development. Although several immunohistochemical studies have shown the ontogeny of chicken gonadotropes during embryogenesis, there is no agreement concerning the temporal and spatial appearance of gonadotropes (Mikami and Takahashi, 1987;Puebla-Osorio et al ., 2002).…”

Section: Introductionmentioning

confidence: 99%

Development of Gonadotropes in the Chicken Embryonic Pituitary Gland

et al. 2004

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“…The secretion of 17β-estradiol in chicken E8 embryos is higher in the left ovary than in the right [Pedernera et al, 1999], and the higher amount of estrogen produced in the left ovary is suggested to protect the left Müllerian duct from the effects of anti-Müllerian hormone (AMH) [Vil-lalpando et al, 2000;Smith and Sinclair, 2001]. This is responsible for the regression of the right Müllerian duct in earlier stages [Oréal et al, 2002].…”

Section: High Usual Suspects Ratiomentioning

confidence: 99%

Gene Expression of Chicken Gonads Is Sex- and Side-Specific

Scheider

Afonso-Grunz²,

Hoffmeier³

et al. 2014

Sex Dev

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In chicken, the left and right female gonads undergo a completely different program during development. To learn more about the molecular factors underlying side-specific development and to identify potential sex- and side-specific genes in developing gonads, we separately performed next-generation sequencing-based deepSuperSAGE transcription profiling from left and right, female and male gonads of 19-day-old chicken embryos. A total of 836 transcript variants were significantly differentially expressed (p < 10^-5) between combined male and female gonads. Left-right comparison revealed 1,056 and 822 differentially (p < 10^-5) expressed transcript variants for male and female gonads, respectively, of which 72 are side-specific in both sexes. At least some of these may represent key players for lateral development in birds. Additionally, several genes with laterally differential expression in the ovaries seem to determine female gonads for growth or regression, whereas right-left differences in testes are mostly limited to the differentially expressed genes present in both sexes. With a few exceptions, side-specific genes are not located on the sex chromosomes. The large differences in lateral gene expression in the ovaries in almost all metabolic pathways suggest that the regressing right gonad might have undergone a change of function during evolution.

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Proliferative and Steroidogenic Effects of Follicle-Stimulating Hormone during Chick Embryo Gonadal Development

Cited by 29 publications

References 18 publications

Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease

Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease

Development of Gonadotropes in the Chicken Embryonic Pituitary Gland

Gene Expression of Chicken Gonads Is Sex- and Side-Specific

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