Prolonged bisphenol-A exposure decreases endocrine pancreatic proliferation in response to obesogenic diet in ovariectomized mice

Oliveira, Kênia M.; Figueiredo, Letícia S.; Araújo, Thiago R.; Freitas, Israelle N.; Silva, Juliana N.; Boschero, Antônio Carlos; Ribeiro, Rosane Aparecida

doi:10.1016/j.steroids.2020.108658

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…In a recent study using ovariectomized mice, long-term exposure to BPA (1 µg/mL in drinking water) and HFD for 90 days led to enlarged islet cells; reduced islet cell proliferation; and upregulated levels of Erβ, GPR30, and pro-inflammatory cytokines (TNF-α and IL-1β) in the islet cells. Based on these results, the authors suggested that BPA exposure enhances pancreatic islet cell dysfunction in postmenopausal women, but further studies are needed to support this suggestion [156].…”

Section: Effects Of Bpa On Pancreatic Tissuesmentioning

confidence: 97%

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

Kang,

Asai,

Toita

2023

JoX

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Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is a well-known endocrine disruptor. Most human exposure to BPA occurs through the consumption of BPA-contaminated foods. Cardiovascular or cardiometabolic diseases such as diabetes, obesity, hypertension, acute kidney disease, chronic kidney disease, and heart failure are the leading causes of death worldwide. Positive associations have been reported between blood or urinary BPA levels and cardiovascular or cardiometabolic diseases. BPA also induces disorders or dysfunctions in the tissues associated with these diseases through various cell signaling pathways. This review highlights the literature elucidating the relationship between BPA and various cardiovascular or cardiometabolic diseases and the potential mechanisms underlying BPA-mediated disorders or dysfunctions in tissues such as blood vessels, skeletal muscle, adipose tissue, liver, pancreas, kidney, and heart that are associated with these diseases.

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Section: Effects Of Bpa On Pancreatic Tissuesmentioning

confidence: 97%

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

Kang,

Asai,

Toita

2023

JoX

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“…Epidemiological evidence found positive associations between BPA exposure and the onset of metabolic diseases such as obesity and type 2 diabetes. Likewise, numerous animal studies indicated that BPA exposure resulted in glucose intolerance, insulin resistance, and modifications in glucose homeostasis [120,121]. The alteration of different biochemical parameters could likewise be observed throughout different generations and be considered an indirect indicator of effects derived from chronic exposure to BPA.…”

Section: Metabolic Effectsmentioning

confidence: 99%

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

Molina-López

Bujalance-Reyes

Ayala-Soldado

et al. 2023

Animals

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Bisphenol A (BPA) is a chemical compound, considered as an “emerging pollutant”, that appears ubiquitously, contaminating the environment and food. It is an endocrine disruptor, found in a multitude of consumer products, as it is a constituent of polycarbonate used in the manufacture of plastics and epoxy resins. Many studies have evaluated the effects of BPA, using a wide range of doses and animal models. In this work, we carried out a review of relevant research related to the effects of BPA on health, through studies performed at different doses, in different animal models, and in human monitoring studies. Numerous effects of BPA on health have been described; in different animal species, it has been reported that it interferes with fertility in both females and males and causes alterations in their offspring, as well as being associated with an increase in hormone-dependent pathologies. Similarly, exposure to BPA has been related to other diseases of great relevance in public health such as obesity, hypertension, diabetes, or neurodevelopmental disorders. Its ubiquity and nonmonotonic behavior, triggering effects at exposure levels considered “safe”, make it especially relevant when both animal and human populations are constantly and inadvertently exposed to this compound. Its effects at low exposure levels make it essential to establish safe exposure levels, and research into the effects of BPA must continue and be focused from a “One Health” perspective to take into account all the factors that could intervene in the development of a disease in any exposed organism.

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“…Foi realizada laparotomia para coleta e pesagem do útero, e das gorduras periuterinas e parametriais. O ganho de peso corporal total durante o período experimental foi obtido pela subtração do peso no dia da eutanásia pelo peso corporal registrado no início do período experimental (OLIVEIRA et al, 2020).…”

Section: Avaliação Da Obesidade E Do Peso Do úTerounclassified

“…Essas evidências experimentais aliadas às observações do nosso estudo, sugerem que há vários fatores que podem regular e interferir nas ações obesogênicas do BPA. Além disso, recentemente demonstramos que apesar de camundongos fêmeas na pós-menopausa expostas ao BPA não apresentarem modificações no peso dos estoques viscerais de gorduraOLIVEIRA et al, 2020), o DE aumentou a deposição de gordura no fígado. Portanto, as ações obesogênicas do BPA podem não ser observadas somente com procedimentos que avaliam macroscopicamente a adiposidade, assim não descartamos que modificações moleculares e funcionais no tecido adiposo possam estar sendo induzidas pelo BPA nas fêmeas OVX CBPA e HBPA.É importante destacar que o peso uterino é um dos indicadores para a avaliação da ação hormonal estrogênica(HENRIQUES, 2013).…”

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Avaliação De Amilases Por Fermentação Submersa Do Fungo Aspergillus Aculeatus

Vasconcelos¹,

Chamy²,

Costa³

et al. 2021

A Estruturação E Reconhecimento Das Ciências Biológicas Na Contemporaneidade 2

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Prolonged bisphenol-A exposure decreases endocrine pancreatic proliferation in response to obesogenic diet in ovariectomized mice

Cited by 11 publications

References 45 publications

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

Avaliação De Amilases Por Fermentação Submersa Do Fungo Aspergillus Aculeatus

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