Prolonged cataleptogenic effects of potentized homoeopathic drugs

Sukul, Nirmal Chandra; Bala, Sujan K.; Bhattacharyya, Bhudev

doi:10.1007/bf00174371

Cited by 36 publications

(22 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other interesting and varied studies have been reported by the group of Sukul, 16 involving the use of four homeopathic remedies (Gelsemium, Cannabis indica, Graphites and Agaricus muscaris) administered orally to albino rats in potencies of 30CH and 200CH. All four remedies augmented the cataleptic effect induced by restriction of movement (restraint) in a similar manner to the reference compound haloperidol (i.p.…”

Section: Catalepsy and Convulsion Modelsmentioning

confidence: 96%

“…Another reason for undertaking a systematic experimental trial of Gelsemium was that this remedy is frequently used in humans for anxiety symptoms, and has already been investigated in studies by other authors which do not, however, always report consistent results. 13,14,16,18,23 In experimental research in homeopathy it is especially important to consolidate new and preliminary data -which can often be unexpected or even contrary to the beliefs of official pharmacology -through statistically solid evidence. We conducted two complete series of experiments testing various Gelsemium dilutions, Assays of homeopathic remedies in rodents P Bellavite et al with small changes and adaptations of methodology: in the first series -the results of which have been recently published 31 and here are further detailed -the LD test was performed the day before the OF on animals (from Harlan Laboratories), which were housed 4 per cage; in the second series of studies (Magnani et al, manuscript in preparation, whose preliminary data are here reported) the LD test was performed the day after the OF test on animals (from Charles River Laboratories), which were housed 2 per cage.…”

Section: Screening Of Six Homeopathic Remediesmentioning

confidence: 98%

See 1 more Smart Citation

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

View full text Add to dashboard Cite

The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple laboratories, and concern Ignatia, Gelsemium, Chamomilla (in homeopathic dilutions/potencies). Nevertheless, there are some interesting results pointing to the possible efficacy of other remedies, and confirming a statistically significant effect of high dilutions of neurotrophic molecules and antibodies. In the second part of this paper we report some recent results obtained in our laboratory, testing Aconitum, Nux vomica, Belladonna, Argentum nitricum, Tabacum (all 5CH potency) and Gelsemium (5, 7, 9 and 30CH potencies) on mice using ethological models of behaviour. The test was performed using coded drugs and controls in double blind (operations and calculations). After an initial screening that showed all the tested remedies (except for Belladonna) to have some effects on the behavioural parameters (light-dark test and open-field test), but with high experimental variability, we focused our study on Gelsemium, and carried out two complete series of experiments. The results showed that Gelsemium had several effects on the exploratory behaviour of mice, which in some models were highly statistically significant (p < 0.001), in all the dilutions/dynamizations used, but with complex differences according to the experimental conditions and test performed. Finally, some methodological issues of animal research in this field of homeopathy are discussed. The "Gelsemium model" - encompassing experimental studies in vitro and in vivo from different laboratories and with different methods, including significant effects of its major active principle gelsemine - may play a pivotal rule for investigations on other homeopathic remedies.

show abstract

Section: Catalepsy and Convulsion Modelsmentioning

confidence: 96%

Section: Screening Of Six Homeopathic Remediesmentioning

confidence: 98%

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Other laboratories have also reported in vivo [16,19,28,29] or in vitro [30] effects of Gelsemium s. in extremely low doses or high dilution/dynamization, but its action at the cellular level has not been fully clarified. To follow up the above evidence of an anxiolytic effect in animal models, we decided to investigate the Gelsemium s. mechanism of action in neuronal models by assessing the drug effects on whole genome expression changes.…”

Section: Introductionmentioning

confidence: 99%

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Marzotto

Olioso

Brizzi

et al. 2014

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundGelsemium sempervirens L. (Gelsemium s.) is a traditional medicinal plant, employed as an anxiolytic at ultra-low doses and animal models recently confirmed this activity. However the mechanisms by which it might operate on the nervous system are largely unknown. This work investigates the gene expression of a human neurocyte cell line treated with increasing dilutions of Gelsemium s. extract.MethodsStarting from the crude extract, six 100 × (centesimal, c) dilutions of Gelsemium s. (2c, 3c, 4c, 5c, 9c and 30c) were prepared according to the French homeopathic pharmacopoeia. Human SH-SY5Y neuroblastoma cells were exposed for 24 h to test dilutions, and their transcriptome compared by microarray to that of cells treated with control vehicle solutions.ResultsExposure to the Gelsemium s. 2c dilution (the highest dose employed, corresponding to a gelsemine concentration of 6.5 × 10-9 M) significantly changed the expression of 56 genes, of which 49 were down-regulated and 7 were overexpressed. Several of the down-regulated genes belonged to G-protein coupled receptor signaling pathways, calcium homeostasis, inflammatory response and neuropeptide receptors. Fisher exact test, applied to the group of 49 genes down-regulated by Gelsemium s. 2c, showed that the direction of effects was significantly maintained across the treatment with high homeopathic dilutions, even though the size of the differences was distributed in a small range.ConclusionsThe study shows that Gelsemium s., a medicinal plant used in traditional remedies and homeopathy, modulates a series of genes involved in neuronal function. A small, but statistically significant, response was detected even to very low doses/high dilutions (up to 30c), indicating that the human neurocyte genome is extremely sensitive to this regulation.

show abstract

“…65 Time factors and prior history also play roles in the direction of effects with homeopathic remedies in animal and cellular models. 22,33,37,66,67 Similarly, seasonal variants (e.g., pollen, temperature, light cycle, and barometric pressures), undocumented differences in menstrual cycles for female participants, or external stress levels for individual subjects over time (e.g., examination-related stress periods in students) could have could each also have confounded the current findings. However, none of those confounding factors was systematically built into the design of this exploratory study.…”

Section: Discussionmentioning

confidence: 89%

Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Bell

Howerter

Jackson

et al. 2012

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

Objectives: Electroencephalography (EEG) offers psychophysiologic tools to improve sensitivity for detecting objective effects in complementary and alternative medicine. This current investigation extended prior clinical research studies to evaluate effects of one of two different homeopathic remedies on resting EEG cordance after an olfactory activation protocol on healthy young adults with remedy-relevant, self-perceived characteristics. Methods: Ninety-seven (7) young adults (N = 97, mean age 19 years, 55% women) with good self-rated global health and screened for homeopathic constitutional types consistent with one of two remedies (either Sulphur or Pulsatilla) underwent three weekly laboratory sessions. At each visit, subjects had 5-minute resting, eyes-closed EEG recordings before and after a placebo-controlled olfactory activation task with their constitutionally relevant verum remedy. One remedy potency (6c, 12c, or 30c) used per week, was presented in a randomized order over the 3 sessions. Prefrontal resting EEG cordance values at Fp1 and Fp2 were computed from artifact-free 2-minute EEG samples from the presniffing and postsniffing rest periods. Cordance derives from an algorithm that incorporates absolute and relative EEG values. Results: The data showed significant two-way oscillatory interactions of remedy by time for ß, a, h, and d cordance, controlling for gender and chemical sensitivity. Conclusions: EEG cordance provided a minimally invasive technique for assessing objective nonlinear physiologic effects of two different homeopathic remedies salient to the individuals who received them. Time factors modulated the direction of effects. Given previous evidence of correlations between cordance and single-photon emission computed tomography, these findings encourage additional neuroimaging research on nonlinear psychophysiologic effects of specific homeopathic remedies.

show abstract

Prolonged cataleptogenic effects of potentized homoeopathic drugs

Cited by 36 publications

References 6 publications

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Contact Info

Product

Resources

About