Prominent efficiency in skin delivery of resveratrol by novel sucrose oleate microemulsion

Yutani, Reiko; Komori, Yuka; Takeuchi, Atsuko; Teraoka, Reiko; Kitagawa, Shuji

doi:10.1111/jphp.12497

Cited by 14 publications

(6 citation statements)

References 30 publications

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“…Labrasol ® (PEG-8 Caprylic/Capric Glycerides -CAS# 85536-07-8) and Transcutol ® (Ethoxydiglycol -CAS# 111-90-0) were gifts from Gattefossé (Saint-Priest, France). Orthophosphoric acid, hematoxylin, eosin and ethanol were purchased from Thermo Fisher Scientific A range of approaches have been investigated to improve the topical delivery of RSV, including micro/nanoemulsions [14], niosomes [15], ethosomes [16], nanosponges [17], microparticles [18], and nanoparticles [19]. Nano/microemulsions provide particular advantages for a topical product formulation because they are transparent optically isotropic and kinetically stable colloids [20].…”

Section: Methodsmentioning

confidence: 99%

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

et al. 2020

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Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and characterized and evaluated for their capabilities to penetrate/permeate the skin. In nanoformulations, the thermodynamic activity of the RSV penetration into/permeation through the skin was correlated with the thermodynamic activity of the RSV in the formulations. When terpenes were incorporated into the nanoformulations, the permeation of RSV through the skin increased and correlated with an increasing lipophilicity of the terpene. The nanoemulsion containing eugenol showed the highest RSV penetration into the stratum corneum (SC) and the epidermis-dermis-follicle region, whereas the limonene containing nanoemulsion had the highest RSV permeation through the skin (the enhancement ratios, compared to a saturated solution of RSV, were (i) 9.55 and (ii) 12.61, respectively, based on the average RSV amount (i) in each skin region and (ii) permeation through skin).

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Section: Methodsmentioning

confidence: 99%

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

et al. 2020

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“…RESV permeated the different layers of the skin in an average concentration of 11.25 ± 6.56 µg/cm 2 136 . When applied in the concentration range of 5-55 mM, the amount of skin incorporation of RESV increased with the applied concentration up to 30 mM, whereas skin incorporation efficiency was inversely proportional to the applied concentration and when applied with 10% ethanol, in the epidermis the concentration was 0.02 µM 137 . Hence, RESV must be used at relatively high concentrations (e.g.…”

Section: Resveratrol and Skinmentioning

confidence: 95%

Resveratrol: from diet to topical usage

et al. 2017

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The stilbene derivative resveratrol (3,5,4'-trihydroxy-stilbene; RESV) has become the subject of interest of many researchers and the pharmaceutical industries due to its well-acclaimed beneficial biological activities. Although earlier research tended to focus on the effects of RESV on cardiovascular disorders, many other studies have described the beneficial effects of RESV in the areas of cancer chemoprevention and inflammation and interest of researchers on this compound is still increasing. It is now well accepted that the effect of RESV is not just due to its so called "antioxidant" activity but mainly (if not only) because of the ability of this compound to trigger cell signaling pathways and gene expression involved in cellular defense systems. Many "in vitro" studies on RESV did not take into account that although its oral absorption is about 75% it undergoes rapid metabolism and the concentration in the blood stream is almost undetectable. For this reason interest in the topical usage of RESV by cosmeceutical skin care brands has exponentially increased in the last decade reporting in general very promising results on its beneficial effect in protecting the skin from outdoor insults, but there is still some controversy on its topical usage mainly surrounding the concentration used. Therefore, more basic research on the topical application of RESV should be performed to better understand the way it prevents cutaneous damage and whether it could be recommended as a preventive skin aging agent for all skin insults.

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“…A recent work by Alonso et al has assessed in both in vitro and in vivo the permeation of topical application of resveratrol, showing that the topically applied resveratrol penetrates into the skin in a gradient fashion and that resveratrol after its penetration was able to maintain its antioxidant efficiency [40]. Nevertheless, it was demonstrated that resveratrol must be used at relatively high concentration for topical in vivo application in order for it to be effective [41].…”

Section: Discussionmentioning

confidence: 99%

Skin Anti-Aging Benefits of a 2% Resveratrol Emulsion

Brinke¹,

Janssens-Böcker²,

Kerscher³

2021

JCDSA

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Background: Young and intact skin is highly responsive. As skin ages, its responsiveness decreases. Production of structural components of the skin slows down and signs of skin aging appear. External influences like UV radiation and pollution contribute to signs of skin aging. They lead to an increased formation of so-called free radicals. Bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health by free radical scavenging. The purpose of this study was to evaluate the topical effects of new and highly concentrated resveratrol containing emulsion (Medskin Solutions Dr. Suwelack AG, 2% trans-resveratrol) on age-related alterations to the skin. Methods: A clinical observation study was performed on 20 subjects to observe the effects of a 2% resveratrol emulsion on typical signs of skin aging. Product was applied once daily for a period of 8 weeks in combination with a standardized treatment. Tested parameters were skin elasticity, skin barrier function, skin smoothness, skin thickness and density. Results: After 8 weeks of treatment, skin pH value is significantly lowered and skin barrier function improved. The value of skin elasticity (+5.3%), and skin density (+ 10.7%) had increased, while skin roughness (−6.4%) and skin dispensability (−45.9%) had diminished. Intensity of skin redness had decreased. Furthermore, expert and participant evaluations show satisfaction, especially with regard to skin smoothness and skin moisture. Conclusion: The resveratrol emulsion shows positive outcomes by supporting reduction of skin wrinkling and increasing skin firmness, as well as reducing skin redness, and is therefore an all-round anti-aging treatment.

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Prominent efficiency in skin delivery of resveratrol by novel sucrose oleate microemulsion

Abstract: MESO-E would be a promising vehicle for the efficient skin delivery of resveratrol, especially when applied at a low concentration.

Cited by 14 publications

References 30 publications

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Resveratrol: from diet to topical usage

Skin Anti-Aging Benefits of a 2% Resveratrol Emulsion

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