Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

Zhao, Fang; Lei, Bo; Li, Xian; Mo, Yunfei; Wang, Renxian; Chen, Dafu; Chen, Xiaofeng

doi:10.1016/j.biomaterials.2018.06.004

Cited by 226 publications

(127 citation statements)

References 57 publications

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“…Silicon‐based bioactive biomaterials such as bioactive glass (BG, typical composition: SiO 2 ‐CaO‐P 2 O 5 ), have been extensively used for bone tissue repair, owing to its good biocompatibility, biodegradation, tissue regeneration ability . Monodispersed BG nanoparticles (BGNs) with enhanced biological performance were also developed for bioimaging, osteogenic differentiation of stem cells, drugs, and gene delivery .…”

Section: Introductionmentioning

confidence: 99%

Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

Zhou

Xue

et al. 2019

Adv Funct Materials

Self Cite

228

121

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The surgical procedure in skin-tumor therapy usually results in cutaneous defects, and multidrug-resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self-healing antibacterial bioactive polypeptide-based hybrid nanosystem is developed for treating multidrug resistant infection, skin-tumor therapy, and wound healing. The multifunctional hydrogel is successfully prepared through incorporating monodispersed polydopamine functionalized bioactive glass nanoparticles (BGN@ PDA) into an antibacterial F127-ε-Poly-L-lysine hydrogel. The nanocomposites hydrogel displays excellent self-healing and injectable ability, as well as robust antibacterial activity, especially against multidrug-resistant bacteria in vitro and in vivo. The nanocomposites hydrogel also demonstrates outstanding photothermal performance with (near-infrared laser irradiation) NIR irradiation, which could effectively kill the tumor cell (>90%) and inhibit tumor growth (inhibition rate up to 94%) in a subcutaneous skin-tumor model. In addition, the nanocomposites hydrogel effectively accelerates wound healing in vivo. These results suggest that the BGN-based nanocomposite hydrogel is a promising candidate for skin-tumor therapy, wound healing, and antiinfection. This work may offer a facile strategy to prepare multifunctional bioactive hydrogels for simultaneous tumor therapy, tissue regeneration, and anti-infection.

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Section: Introductionmentioning

confidence: 99%

Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

Zhou

Xue

et al. 2019

Adv Funct Materials

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228

121

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“…However, in the present work, the whole PLGA network in the PLGA/CPC and PLGA/WS/CPC composites was replaced with bone matrix and bone remodeling related cells (Figures S4 and S7, Supporting Information). The enhanced angiogenesis of grafts at early stages was beneficial to the increase of new bone formation . The fast degradation of the PLGA network in the PLGA/CPC and PLGA/WS/CPC composites significantly improved the ingrowth of blood vessels (Figure S8, Supporting Information).…”

Section: Discussionmentioning

confidence: 99%

Novel Strategy to Accelerate Bone Regeneration of Calcium Phosphate Cement by Incorporating 3D Plotted Poly(lactic‐co‐glycolic acid) Network and Bioactive Wollastonite

Qian

Fan

et al. 2019

Adv Healthcare Materials

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Inefficient bone regeneration of self‐hardening calcium phosphate cement (CPC) increases the demand for interconnected macropores and osteogenesis‐stimulated substances. It remains a challenge to fabricate porous CPC with interconnected macropores while maintaining its advantages, such as plasticity. Herein, pastes containing CPC and wollastonite (WS) are infiltrated into a 3D plotted poly(lactic‐co‐glycolic acid) (PLGA) network to fabricate plastic CPC‐based composite cement (PLGA/WS/CPC). The PLGA/WS/CPC recovers the plasticity of CPC after being heated above the glass transition temperature of PLGA. The presence of the 3D PLGA network significantly increases the flexibility of CPC in prophase and generates 3D interconnected macropores in situ upon its degradation. The addition of WS is helpful to improve the attachment, proliferation, and osteogenic differentiation of mouse bone marrow stromal cells in vitro. The in vivo experimental results indicate that PLGA/WS/CPC promotes rapid angiogenesis and bone formation. Therefore, the plastic CPC‐based composite cement with a 3D PLGA network and wollastonite shows an obviously improved efficiency for repairing bone defects and is expected to facilitate the wider application of CPC in the clinic.

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“…For example, Sr containing BG microspheres (Sr-BGM) have been shown to signi cantly improve early angiogenesis via modulating macrophages towards the M2 phenotype expressing a great value of platelet-derived growth factor-BB (PDGF-BB). The authors assumed that this early vascularization could e ciently promote new tissue regeneration , including bone formation [24]. Also, osteogenic capability of thermosensitive p (N-Isopropylacrylamide-co-butyl Methylacrylate) hydrogel (PIB nanogel) was increased signi cantly following the addition of mesoporous bioactive glass containing Sr (Sr-MBG).…”

Section: Introductionmentioning

confidence: 99%

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2020

Preprint

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Background: Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration.Methods: In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Alizarin Red, Hematoxylin & Eosin (H&E) and Masson’s Trichrome staining were performed to assess bone regeneration and the obtained results were compared with those without Sr. Also, histomorphometric data were obtained to evaluate the new bone, residual graft, and connective tissue.Results: Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation showed that although both Gel-BG/Sr and Gel-BG effectively inhibited the growth of Escherichia coli (E. coli) but, only Gel-BG/Sr structure could lead to a 3 log reduction in Staphylococcus aureus (S. aureus). Conclusions: Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.

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Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

Cited by 226 publications

References 57 publications

Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

Novel Strategy to Accelerate Bone Regeneration of Calcium Phosphate Cement by Incorporating 3D Plotted Poly(lactic‐co‐glycolic acid) Network and Bioactive Wollastonite

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

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