Promotion and Inhibition of Ruminal Epithelium Growth by Butyric Acid and Insulin-Like Growth Factor-1 (IGF-1) in Dairy Goats

Liu, Dacheng; Zhou, Xiang-li; Guojuan, Liu; Gao, Min; Hu, Hong-lian

doi:10.1016/s2095-3119(13)60603-6

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propionate and butyrate were believed to play an important role in cell growth, but several studies have contradictory opinions on the effects of these two VFAs ( Baldwin, 1999 ; Shen et al, 2005 ). Liu et al (2014) indicated that butyrate needed to be used in combination with insulin-like growth factor-1 (IGF-1) to significantly promote DNA replication, and otherwise it can inhibit DNA replication. In the present study, we found up-regulation of the gene encoding insulin-like growth factor binding protein 5 in the HS cows, which might enhance the biological effects of IGF-1.…”

Section: Discussionmentioning

confidence: 99%

Effects of Heat Stress on the Ruminal Epithelial Barrier of Dairy Cows Revealed by Micromorphological Observation and Transcriptomic Analysis

et al. 2022

View full text Add to dashboard Cite

Heat stress (HS) alters the rumen fermentation of dairy cows thereby affecting the metabolism of rumen papillae and thus the epithelial barrier function. The aim of the present study was to investigate if HS damages the barrier function of ruminal epithelia. Eight multiparous Holstein dairy cows with rumen cannula were randomly equally allocated to two replicates (n = 4), with each replicate being subjected to heat stress or thermal neutrality and pair-feeding in four environmental chambers. Micromorphological observation showed HS aggravated the shedding of the corneum and destroyed the physical barrier of the ruminal epithelium to a certain extent. Transcriptomics analysis of the rumen papillae revealed pathways associated with DNA replication and repair and amino acid metabolism were perturbated, the biological processes including sister chromatid segregation, etc. were up-regulated by HS, while the MAPK and NF-kB cell signaling pathways were downregulated. However, no heat stress-specific change in the expression of tight junction protein or TLR4 signaling was found, suggesting that HS negatively affected the physical barrier of the ruminal epithelium to some extent but did not break the ruminal epithelium. Heat stress invoked mechanisms to maintain the integrity of the rumen epithelial barrier by upregulating the expression of heat shock protein and repairments in rumen papillae. The increase in amino acid metabolism in rumen papillae might affect the nutrient utilization of the whole body. The findings of this study may inform future research to better understand how heat stress affects the physiology and productivity of lactating cows and the development of mitigation strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Heat Stress on the Ruminal Epithelial Barrier of Dairy Cows Revealed by Micromorphological Observation and Transcriptomic Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…GH plays an important role in consuming fat, promoting protein synthesis, and improving growth and development of livestock (Hua et al, 2009). IGF‐1 is one of the growth‐promoting endocrine hormones, which plays a key role in regulation of other hormones, such as GH and GnRH (Liu et al, 2014; Wang et al, 2011). This study found a high concentration of rutin could increase the GH and IGF‐1 concentrations on Day 40, which was similar with the results of Muqier et al (2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of rutin supplementation on growth performance, slaughter performance, serum parameters, and meat quality of Nubian goats

Jinshun

Wang

et al. 2023

Animal Science Journal

View full text Add to dashboard Cite

Previous studies found that rutin can improve production performance of sheep and dairy cows. However, it is not clear whether rutin has similar effects in goats. Hence, the aim of this experiment was to study the effects of rutin supplementation on growth performance, slaughter performance, serum parameters, and meat quality of Nubian goats. A total of 36 healthy Nubian ewes were randomly divided into three groups. Goats were fed the basal diet supplemented with 0 (R0), 25 (R25), and 50 (R50) mg rutin per kg of diet. The growth performance and slaughter performance of goats had no significant difference among three groups. The meat pH45min and moisture were significantly higher in the R25 group than the R50 group (p < 0.05), but the color value b* and contents of C14:0, C16:0, C18:0, C18:1n9c, C20:1, saturated fatty acid (SFA), and monounsaturated fatty acid (MSFA) in meat had an opposite outcome. The dressing percentage had an increasing tendency in the R25 group compared with the R0 group (0.05 < p < 0.10), but the shear force, water loss rate and crude protein of meat had opposite results. In conclusion, rutin could not affect the growth performance and slaughter performance of goats; low levels could possibly improve meat quality.

show abstract

Role of butyrate as part of milk replacer and starter diet on intestinal development in pre-weaned calves. A systematic review

Amin

Trabi

Zhu³

et al. 2022

Animal Feed Science and Technology

View full text Add to dashboard Cite

Promotion and Inhibition of Ruminal Epithelium Growth by Butyric Acid and Insulin-Like Growth Factor-1 (IGF-1) in Dairy Goats

Cited by 3 publications

References 11 publications

Effects of Heat Stress on the Ruminal Epithelial Barrier of Dairy Cows Revealed by Micromorphological Observation and Transcriptomic Analysis

Effects of Heat Stress on the Ruminal Epithelial Barrier of Dairy Cows Revealed by Micromorphological Observation and Transcriptomic Analysis

Effects of rutin supplementation on growth performance, slaughter performance, serum parameters, and meat quality of Nubian goats

Role of butyrate as part of milk replacer and starter diet on intestinal development in pre-weaned calves. A systematic review

Contact Info

Product

Resources

About