Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cao, Liehu; Weng, Weizong; Chen, Xiao; Zhang, Jun; Zhou, Qian-Mei; Cui, Jinghua; Zhao, Yuechao; Shin, Jung-Woog; Su, Jiacan

doi:10.2147/ijn.s124965

Cited by 28 publications

(19 citation statements)

References 31 publications

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“…16−18 It indicates that calcium sulfate has good properties of promoting bone healing. 19 In other words, calcium sulfate can be used as a carrier for proangiogenic drugs. However, it has been proved that pure calcium sulfate materials degrade so faster than bone regeneration that it may lead to the formation of voids in the bone defect area and hinder osteogenesis after full degradation.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium sulfate has been widely used as a host material to design resorbable orthopedic implanted materials due to its biodegradability, biocompatibility, and osteoconductivity . Besides, calcium sulfate, because of its good self-curing properties, has been proved that it could be used as a desirable drug carrier for local spatial and temporal sustained release in previous studies. − It indicates that calcium sulfate has good properties of promoting bone healing . In other words, calcium sulfate can be used as a carrier for proangiogenic drugs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Copper-Loaded Biodegradable Bone Wax with Antibacterial and Angiogenic Properties in Early Bone Repair

Yan

Tie³

et al. 2021

ACS Biomater. Sci. Eng.

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Traditional bone wax has lots of shortcomings such as the risk of infection and inflammation and the ability to hinder osteogenesis that limit its clinical applications. In this study, we designed a novel biodegradable bone wax with desirable angiogenic and antibacterial ability and low foreign body reaction by mixing calcium sulfate, poloxamer, and cupric ions. To evaluate its biocompatibility and angiogenetic effect in vitro, we cultured human umbilical vein endothelial cells (HUVECs) with the indicated bone wax to observe cell viability and vessel-like tubular formation. The bone wax was then implanted in a critical-sized bone defect rat model for 4 and 8 weeks to successfully stimulate angiogenesis in vivo. Finally, the bone wax extract was incubated with Gram-positive Staphylococcus aureus to confirm its antibacterial ability. The copper-loaded biodegradable bone wax overcomes the drawbacks of traditional bone wax and provides a new approach for the treatment of bone injuries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Copper-Loaded Biodegradable Bone Wax with Antibacterial and Angiogenic Properties in Early Bone Repair

Yan

Tie³

et al. 2021

ACS Biomater. Sci. Eng.

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“…Several studies have reported that lithium can promote osteogenic differentiation of BMSCs by activating the Wnt/GSK-3 signaling pathway 15 , 16 . In vivo studies demonstrated that lithium has promoting effect on bone regeneration and can improve osteoporosis 17 , 18 . In recent studies, lithium salts have been introduced into bone tissue engineering and have been shown to play an important role in improving the osteogenesis of biomaterials 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Repair of segmental bone defect using tissue engineered heterogeneous deproteinized bone doped with lithium

Wang

et al. 2021

Sci Rep

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Lithium have been shown to play an important role in improving the osteogenic properties of biomaterials. This study aims to explore the osteogenic improvement effect of tissue engineered heterogeneous deproteinized bone (HDPB) doped with lithium, and evaluate their effectiveness in the healing of bone defects. Bone marrow mesenchymal stem cells (BMSCs) were co-cultured with different concentration of lithium chloride. Cell proliferation in each group was analyzed by 3-(4, 5-dimetyl-2-thiazoly-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay. BMSCs were then co-cultured in osteogenic induction medium with different concentration of lithium chloride, and the expression of related mRNA was detected. The role of lithium in promoting BMSCs osteogenic differentiation and inhibiting BMSCs lipogenic differentiation was also investigated. Biomechanical properties of the tibia were evaluated at 8 weeks after operation. The tibial specimens of each group were collected at 4 and 8 weeks after surgery for histological examination and histological analysis. Micro-computed tomography (CT) scanning and 3D reconstruction were performed at 8 weeks. The results demonstrate that lithium can induce the osteogenic differentiation inhibit of adipogenic differentiation of BMSCs by regulating the Wnt signaling pathway. The histological evaluation further certified that average bone formation area in the group of tissue engineered HDPB doped with lithium was also significantly better than that of HDPB alone group. Based on the above evaluation, tissue engineered HDPB doped with lithium can effectively promote the regeneration of segmental bone defect, which can be used as a tissue engineering scaffold for clinical trials.

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“…A nanoporous structure on biomaterials can promote cell adhesion, proliferation, differentiation, and osteogenesis-related gene expressions, while macroporous structures accelerate osteogenesis and improve mechanical interlocking of ingrowth of NBs, providing greater mechanical stability at the critical interface and hence promoting ossteointegration 21. Nanoporous magnesium silicate (nMS) is a bioactive glass that possesses a nanoporous structure with large surface area and high pore volume 18. Our previous research has confirmed that the nMS exhibits superior in vitro bioactivity, cytocompatibility, and in vivo osteogenesis 19…”

Section: Introductionmentioning

confidence: 99%

<p>Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone</p>

Wang

Zhang

Hao

et al. 2019

IJN

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The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.

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Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cited by 28 publications

References 31 publications

Copper-Loaded Biodegradable Bone Wax with Antibacterial and Angiogenic Properties in Early Bone Repair

Copper-Loaded Biodegradable Bone Wax with Antibacterial and Angiogenic Properties in Early Bone Repair

Repair of segmental bone defect using tissue engineered heterogeneous deproteinized bone doped with lithium

<p>Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone</p>

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