“…However, the results achieved statistical significance only in the study by Guerin et al [ 10 ]. Although it cannot be determined whether initiation of prone positioning alone impacted the results, timing should be considered a necessary element of developing a prone positioning protocol [ 1 - 2 , 5 , 7 - 8 ]. Unless a patient has specific risk factors for which prone positioning is contraindicated, it seems plausible to initiate this intervention as early as possible, considering there are clear benefits to initiating the prone position, i.e., improved oxygenation, decreased atelectasis, and decreased risk of ventilator-associated pneumonia.…”