Proniosome-Derived Niosomes for the Delivery of Poorly Soluble Drugs

Rhodes, David G.; Blazek-Welsh, Almira I.

doi:10.1021/bk-2004-0879.ch003

Cited by 3 publications

(2 citation statements)

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“…5 The limitations of phospholipid-based liposomes as drug delivery systems (hydrolysis and oxidative degradation) prompted investigations on using vesicles of other amphiphilic substances, e.g., polymers and surfactants. [6][7][8][9] Vesicles also act as a transdermal drug solubilization systems; this application reduces the toxicity and enhances the skin permeation of the drug. 10 Vesicles prepared from cationic surfactants have advantages over liposomes and non-ionic surfactants (niosomes), because their formulation is simple and their chemical stability against hydrolytic and oxidative degradation in aqueous medium is high.…”

Section: Introductionmentioning

confidence: 99%

Drug induced micelle-to-vesicle transition in aqueous solutions of cationic surfactants

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Drug induced micelle-to-vesicle transition in aqueous solutions of cationic surfactants

et al. 2017

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“…Therefore, the search for new supramolecular vesicles of alternative substances is a long-standing topic of research. The past few years have witnessed a significant drug delivery shift in the biomedical arena by developing various new nonphospholipid vesicular systems composed of common surfactants and polymers. − …”

Section: Introductionmentioning

confidence: 99%

Vesicles Formed in Aqueous Mixtures of Cholesterol and Imidazolium Surface Active Ionic Liquid: A Comparison with Common Cationic Surfactant by Water Dynamics

et al. 2014

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The formation of stable unilamellar vesicles which hold great potential for biological as well as biomedical applications has been reported in the aqueous mixed solution of a surface active ionic liquid (SAIL), 1-hexadecyl-3-methylimidazolium chloride ([C16mim]Cl) and cholesterol. To make a comparison we have also shown the formation of such stable vesicles using a common cationic surfactant, benzyldimethylhexadecylammonium chloride (BHDC) which has a similar alkyl chain length but different headgroup region to that of [C16mim]Cl. It has been revealed from dynamic light scattering (DLS), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), and other optical spectroscopic techniques that the micelles of [C16mim]Cl and BHDC in aqueous solutions transform into stable unilamellar vesicles upon increasing concentration of cholesterol. We find that, as the concentration of cholesterol increases, the solvation and rotational relaxation time of C153 in [C16mim]Cl/cholesterol solution as well as in BHDC/cholesterol solution gradually increases indicating a significant decrease in the hydration behavior around the self-assemblies upon micelle-vesicle transition. However, the extent of increase in solvation and rotational relaxation time is more prominent in the case of [C16mim]Cl/cholesterol solutions than in the BHDC/cholesterol system. This indicates that [C16mim]Cl/cholesterol vesicular membranes are comparatively less hydrated and more rigid than the BHDC/cholesterol vesicular bilayer.

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Synergistic Interaction between Cholesterol and Functionalized Ionic Liquid Based Surfactant Leading to the Morphological Transition

et al. 2018

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Stable vesicular aggregate is the primary requisite to transport and deliver the biological and pharmaceutical standards. The serendipitous discovery of nonlipid vesicles made with the nonlipid building blocks, such as ionic liquid based surfactants (ILBSs) proved to be advantageous over others. In a quest to achieve stable, more rigid and hydrophobic vesicles from ILBSs, here we have investigated the lipid (cholesterol) induced unilamellar vesicle formation in the aqueous functionalized and nonfunctionalized ILBSs. The vesicles show outstanding stability with time, temperature and dilution with water. Spectroscopic (turbidity, steady state absorbance and fluorescence), scattering (dynamic light scattering) and microscopic (transmission electron microscopy) techniques were used to characterize the vesicles. The hydration behavior and rigidity associated with the vesicular bilayer on transforming from micellar assembly was characterized through steady state absorbance and fluorescence techniques. The unilamellar vesicles derived are compared with the conventional surfactant, i. e. cetyltrimethyl ammonium bromide.[a] Dr.

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Proniosome-Derived Niosomes for the Delivery of Poorly Soluble Drugs

Cited by 3 publications

References 0 publications

Drug induced micelle-to-vesicle transition in aqueous solutions of cationic surfactants

Drug induced micelle-to-vesicle transition in aqueous solutions of cationic surfactants

Vesicles Formed in Aqueous Mixtures of Cholesterol and Imidazolium Surface Active Ionic Liquid: A Comparison with Common Cationic Surfactant by Water Dynamics

Synergistic Interaction between Cholesterol and Functionalized Ionic Liquid Based Surfactant Leading to the Morphological Transition

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