Proof that colostrum polio antibodyis different from serum antibody

Hodes, Horace L.; Berger, Rachel P.; Ainbender, Eugene; Hevizy, Maria M.; Zepp, Helen D.; Kochwa, Shaul

doi:10.1016/s0022-3476(64)80037-8

Cited by 37 publications

(7 citation statements)

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“…coli antibodies in human milk primarily seem to be of the secretory IgA class (Hodes et al, 1964;Hanson and Johansson, 1970), though small amounts of IgG and IgM are also found in milk (Hanson and Johansson, 1970). Antibody activity against other micro-organisms like polio virus, streptococci, and pneumococci has also been shown in the secretory IgA fraction of human milk (Hodes et al, 1964;Hanson and Johansson, 1970;Mouton et al, 1970). The secretory IgA molecule is more resistant to pH changes and proteolytic enzymes than is serum IgA or other immunoglobulins (Tomasi and Bienenstock, 1968;Hanson and Brandtzaeg, 1972), which may enable the secretory IgA antibodies of milk to function in the variable milieu of the gut.…”

Section: Components and Properties Of Breast Milk Which May Provide Imentioning

confidence: 99%

Breast milk and defence against infection in the newborn.

Hanson¹,

Winberg²

1972

Archives of Disease in Childhood

220

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Section: Components and Properties Of Breast Milk Which May Provide Imentioning

confidence: 99%

Breast milk and defence against infection in the newborn.

Hanson¹,

Winberg²

1972

Archives of Disease in Childhood

220

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“…Not much is known about the antibody content of this fraction, but there is recent evidence that some of the skin sensitizing antibodies in allergic individuals may belong to the (3m-globulins (Heremans and Vaerman, 1962;Rockey and Kunkel, 1962) as well as Brucella abortus and diphtheria antibodies (Heremans, Vaerman, and Vaerman, 1963). Colostrum has been found to contain (3A antibodies against a 24: number of viruses and bacteria (Hodes, Berger, Ainbender, Hevizy, Zepp, and Kochwa, 1964).…”

mentioning

confidence: 99%

A Study of the Immunoglobulins in Premature Infants

Haworth¹,

Norris²,

Dilling³

1965

Archives of Disease in Childhood

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“…Work with poliovirus vaccines provided the first direct evidence that secretory antibodies (in colostrum administered to nursing in¬ fants) could neutralize the virus and prevent colonization of intestine (Hodes et al 1964;Katz Se Plotkin 1968;Sabbi Se Ficldsteel 1962). Work with poliovirus vaccines provided the first direct evidence that secretory antibodies (in colostrum administered to nursing in¬ fants) could neutralize the virus and prevent colonization of intestine (Hodes et al 1964;Katz Se Plotkin 1968;Sabbi Se Ficldsteel 1962).…”

Section: Direct Application Of Antigenmentioning

confidence: 99%

Techniques for Eliciting Mucosal Immune Response

Waldman¹,

Ganguly²

1975

Acta Endocrinologica

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Development of techniques for eliciting an immune response on mucosal surfaces is a relatively new area of clinical research. With the recognition of the existence of secretory immunity, independent of the systemic system, there was renewed interest in re-examining the conventional approach for optimal immunization techniques. A large body of data indicate that the majority of the secretory immunoglobulins and antibody produced to antigenic stimulation of mucosal surfaces is locally produced. Thus, antibody to C. albicans in the cervical or vaginal mucus has been shown to be of local origin and it predominantly belongs to the secretory IgA immunoglobulin class. The mechanism of antigen processing by the secretory surface leading to antibody formation remains a mystery, but it might be determined by the selective localization of antigens in the reticuloendothelial cells of the lamina propria, bronchi or small intestine. Usually application of antigen topically to the mucosal surface elicits local antibody formation to a greater extent than does parenteral immunization. On the other hand, a more pronounced systemic immune response is seen when the antigen is administered systemically. However, a number of other factors determine the quality and quantity of the immune response, e. g., the physical state of the antigen, live vs killed vaccine, dose, adjuvant, previous exposure to similar or cross-reacting antigens, and site of application of the antigen. These factors are discussed in the review. Recent observations suggest that cell mediated immunity is a component of the secretory immune system, and like the humoral mechanism, also may be partially compartmentalized. of the secretory system, about which very little is yet known.

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Proof that colostrum polio antibodyis different from serum antibody

Cited by 37 publications

References 0 publications

Breast milk and defence against infection in the newborn.

Breast milk and defence against infection in the newborn.

A Study of the Immunoglobulins in Premature Infants

Techniques for Eliciting Mucosal Immune Response

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