Properties of a cell-bound homogeneous murine IgM anti-dextran—IV. Modification of reactions of cell-bound IgM by concanavalin A

Concanavalin A (Con A), either in solution or insolubilized by covalent binding to Sepharose 4B, can inhibit the ability of fluid phase 19S, but not 7S, anti-Forssman antibody to sensitize sheep red cells (E) toward lysis by excess guinea pig complement. The efficiency of 19S antibody is unaffected when E are treated with Con A before sensitization or when antibody sensitized cells (EA) are exposed to the lectin before complement is added. Although whole complement activity is retained on a solumn of Con A-Sepharose, cell bound lectin did not act as a complement fixing antibody. Consistent with this result, there was no difference in the amount of C1 fixed by E and E-Con A, or by EA and EA-Con A.

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Properties of a cell-bound homogeneous murine IgM anti-dextran—IV. Modification of reactions of cell-bound IgM by concanavalin A

Cited by 3 publications

References 31 publications

Properties of a cell-bound homogeneous murine IgM anti-dextran-V

Properties of a cell-bound homogeneous murine IgM anti-dextran-V

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