Properties of a Model Aryl Boronic Acid and Its Boroxine

In vitroandin vivoantitumor activity of the halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate (K2[B3O3F4OH])

“…Based on the results of this study, it has undoubtedly found that K 2 enzymes such as tyrosinases and especially tyrosine kinases. As known several oncogenic tyrosine kinases have been detected in human malignancies.…”

“…In this article, as presented in the ''Results'' section, the detailed in vitro investigation on 4T1 mammary adenocarcinoma, B16F10 melanoma and squamous cell carcinoma SCCVII undoubtedly showed that K 2 …”

“…Boroxines are the dehydration products of organoboronic acids and their derivatives such as trimethylboroxine, triphenylboroxine and halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate K 2 [B 3 O 3 F 4 OH] also make up a broader class of compounds called boroxines 1,2 . Due to their unique electronic structures, these compounds are currently under investigation as possible enzyme inhibitors and therapeutics.…”

Solubility of phenylboronic compounds in water

“…The acid/boroxine equilibrium depends on the substituents in the aryl group. DSC measurements of the p-methoxyphenylboronic acid confirm that the fast dehydration starts at about 90°C 15 . However, some compounds dehydrate easily during standing on air at room temperature.…”

Impact of calcium ion on cytotoxic effect of the boroxine derivative, K2[B3O3F4OH]

“…Boroxines are the dehydration products of organoboronic acids and their derivatives such as trimethylboroxine and triphenylboroxine 1,2 . Due to their unique electronic structures, these compounds are currently under investigation as possible enzyme inhibitors and therapeutics.…”