Properties of Powder Composite Polyhydroxybutyrate–Chitosan-Calcium Phosphate System

Medvecký, Ľubomír; Štulajterová, Radoslava; Giretová, Maria; Fáberová, Mária

doi:10.1515/pmp-2017-0001

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The mature bone cells, osteoblasts, adhered to the ceramic material and were able to proliferate and produce extracellular matrix without any toxic products [ 29 ]. The initial cell attachment was affected by alkaline phosphatase activity that favoured surfaces with smooth texture [ 17 ]. In the later phases of bone cell adhesion, the surface of the biomaterial played a very important role.…”

Section: Discussionmentioning

confidence: 99%

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Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An In Vivo Study

Vdoviaková

Jenča²,

Danko

et al. 2023

Biomedicines

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Reconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the body’s own substances. Hydroxyapatite ceramic scaffolds have fully acceptable phase compositions, microstructures and compressive strengths for their use in regenerative medicine. The innovative hydroxyapatite ceramics used by us were prepared using the tape-casting method, which allows variation in the shape of samples after packing hydroxyapatite paste to 3D-printed plastic form. The purpose of our qualitative study was to evaluate the regenerative potential of the innovative ceramic biomaterial prepared using this method in the therapy of the cortical bone of the lower jaw in four mature pigs. The mandible bone defects were evaluated after different periods of time (after 3, 4, 5 and 6 months) and compared with the control sample (healthy cortical bone from the opposite side of the mandible). The results of the morphological, clinical and radiological investigation and hardness examination confirmed the positive regenerative potential of ceramic implants after treatment of the mandible bone defects in the porcine mandible model.

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Section: Discussionmentioning

confidence: 99%

“…The detachment strength of the osteoblast cells was related to surface roughness, fibronectin preadsorption and integrin subunit sensitivity. An in vitro study showed that the short- and longer-term responses of bone marrow cells were improved with the roughness of the HAP material [ 17 ].…”

Section: Introductionmentioning

confidence: 99%